p53 Family: The Molecular Landscape in Cancer and Beyond
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 40
Special Issue Editors
Interests: p53 family members; microRNA; tumorigenesis; metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The p53 family of transcription factors, which includes p53, p63, and p73, plays a crucial role in maintaining genomic stability, regulating cell cycle progression, and coordinating cellular responses to stress. These proteins are not only central to tumor suppression but also influence a broad spectrum of biological processes, such as development, differentiation, and metabolism. Dysregulation of the p53 family is a hallmark of cancer, with TP53 mutations being the most common genetic alterations in human malignancies. Beyond cancer, emerging evidence highlights their involvement in aging, neurodegenerative diseases, and immune regulation, underscoring their multifaceted roles in health and disease.
This Special Issue aims to explore the latest advancements in understanding the molecular mechanisms, regulatory networks, and therapeutic potential of the p53 family. We invite original research articles and reviews that investigate the structural and functional diversity of these proteins, their interactions with other signaling pathways, their regulation by microRNAs, and their implications in cancer and other diseases. Contributions focusing on innovative therapeutic strategies, such as the targeted reactivation of p53 family members or the exploitation of their isoforms, are also highly encouraged.
We look forward to receiving your contributions, which will help to elucidate the complex roles of the p53 family and pave the way for novel diagnostic and therapeutic approaches.
Dr. Paola Tucci
Dr. Michele Pellegrino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- p53 family
- microRNA
- tumorigenesis
- aging
- neurodegenerative diseases
- immune regulation
- biomarkers
- therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
