Function and Regulation of Hyaluronan and Hyalectins in Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 2993
Special Issue Editors
Interests: endocytosis; scavenger receptor; ligand; sinusoidal endothelium; receptor turnover; clearance; glycosaminoglycan
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hyaluronan and its interacting proteins (hyalectins) are increasingly recognized as important molecules for homeostasis and disease. The simplicity of hyaluronan, which is a polymer of alternating sugars glucuronate and N-acetylglucosamine, is also one of the largest molecules in mammals. It contains both hydrophobic and hydrophilic properties including a net negative charge that allows it to interact with a variety of proteins and receptors that influence a host of physiological functions. These physiological functions include inflammation, intercellular structure, cellular development and differentiation, cellular signaling, cancer, and metabolism.
In this Special Issue of Biomolecules, we would like to highlight the recent discoveries of the importance of hyaluronan in our general well-being, in diseases when it goes awry and its role in medical devices and cosmetics. We also invite a rigorous discussion of how novel advances in hyaluronan research would improve therapeutic outcomes from cancer to arthritis to pulmonary diseases. Both research papers (in particular) and reviews (both focused or general) are welcome.
Prof. Dr. Edward N. Harris
Prof. Dr. Michele T. Pritchard
Guest Editors
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Keywords
- hyaluonan
- glycosaminoglycan
- hyalectan
- cancer
- extracellular matrix
- cellular signaling
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