Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 40
Special Issue Editors
Interests: retinal metabolism; angiogenesis; photoreceptors
Interests: metabolism; inflammation; fibrosis; angiogenesis; retinal degeneration
Interests: pediatric ophthalmology; retinopathy of prematurity; risk factors; biomarkers; prevention
Interests: ophthalmology; retina
Special Issue Information
Dear Colleagues,
The abnormal growth of new blood vessels in the retina and choroids in many eye disorders is vision-threatening across all age groups. Current treatments offer limited efficacy and may be associated with significant side effects. Inflammation and metabolic dysregulation play a key role in retinal vascular and neuronal dysfunction. However, the precise mechanisms linking inflammation, metabolic imbalance, pathological neovascularization, and neuronal damage remain incompletely understood. Further investigation to elucidate disease pathophysiology and progression is needed in order to explore possible new treatment methods and preventative strategies.
In experimental studies, emerging evidence has shown a cell-specific preference for fuel substrates and metabolic pathways for energy production in the retina. A metabolic imbalance between the retinal pigment epithelium and photoreceptors may cause various retinal diseases. In clinical randomized studies, anti-inflammatory and nutritional supplementation to reduce metabolic stress has shown promising results in reducing retinal morbidities. More research is necessary in order to understand metabolic adaptation during stress in both experimental and clinical settings.
This Research Topic will bridge basic science and clinical practice by proposing a translational approach. It will enhance our understanding of neuronal metabolism, inflammation, and the interplay between various retinal cell types in the context of retinal diseases. It will highlight novel therapeutic interventions and preventive strategies currently under investigation or in clinical use for the treatment of retinal disorders.
Dr. Zhongjie Fu
Dr. Qiuhua Yang
Dr. Pia Lundgren
Guest Editors
Dr. Yan Zeng
Dr. Chuanyu Guo
Guest Editor Assistants
Manuscript Submission Information
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Keywords
- inflammation
- metabolism
- neovascularization
- retinal degeneration
- photoreceptors
- Muller glia
- RPE
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