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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Enolase: Molecular Functions and Pathological Roles in Health and Disease

edited by

Anja Pišlar

submission deadline 30 Jun 2026 | Viewed by 62 | Submission Open

Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

Plant Secondary Metabolism Engineering and Bioactive Compounds

edited by

Barbara Tokarz

and

Wojciech Makowski

submission deadline 30 Jun 2026 | Viewed by 58 | Submission Open

Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Multifunctional Nanocarriers for Advanced Therapy and Diagnosis

edited by

Buddhadev Layek

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles

(This special issue belongs to the Section Bio-Engineered Materials)

Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition

edited by

Mateusz Banach

submission deadline 30 Jun 2026 | Viewed by 54 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanism of Viral Infection and Host Immunity in Transplantation

edited by Eva Mischak Weissinger

submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open

Keywords: allogeneic stem cell/or solid organ transplantation; immunosuppressed host; immune reconstitution; virus reactive/specific cytotoxic T-/NK-cells; immune reconstitution post-transplantation

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Their Applications in Biomedicine—2nd Edition

edited by

George Pasparakis

submission deadline 30 Jun 2026 | Viewed by 43 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

Second Messenger Systems in Cellular Communication and Disease

edited by

Vijay Parashar

submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open

Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets

(This special issue belongs to the Section Molecular Biology)

Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights

edited by Anna Barbara Di Stefano

submission deadline 30 Jun 2026 | Viewed by 24 | Submission Open

Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 15 Jul 2026 | 3 articles | Viewed by 4118 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Regulation of Synapses in the Brain

edited by

Kunwei Wu

and Guohao Wang

submission deadline 17 Jul 2026 | 1 articles | Viewed by 1073 | Submission Open

Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Mechanisms of RNA Regulation in Inflammation

edited by

Roopa Biswas

submission deadline 17 Jul 2026 | 1 articles | Viewed by 930 | Submission Open

Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Genetics)

Protein Acetylation and Methylation—from Gene Regulation to Epigenetics, Metabolism, and Beyond

edited by

Kangling Zhang

submission deadline 17 Jul 2026 | Viewed by 38 | Submission Open

Keywords: protein acetylation; protein methylation; histone modification; epigenetics; gene regulation; chromatin remodeling; metabolism; signal transduction; post-translational modification (PTM); proteomics; cancer biology; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 20 Jul 2026 | 3 articles | Viewed by 9422 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Cellular and Non-Cellular Treatment of Stroke

edited by

David T. Harris

submission deadline 20 Jul 2026 | 1 articles | Viewed by 4537 | Submission Open

Keywords: stroke; treatment; therapy; biomolecules; stem cells

(This special issue belongs to the Section Molecular Medicine)

Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases

edited by Mirela Baus Lončar

submission deadline 20 Jul 2026 | Viewed by 38 | Submission Open

Keywords: protective biomolecules; metabolic homeostasis; insulin resistance; insulin resistance; insulin resistancecancer metabolism

(This special issue belongs to the Section Molecular Medicine)

Developmental-Related Brain Disorders

edited by

Ricardo Rodrigues

submission deadline 20 Jul 2026 | Viewed by 33 | Submission Open

Keywords: neurogenesis; neuronal migration; cell differentiation; axon pathfinding; synaptogenesis; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Medicine)

Wound Repair and Regeneration: From Molecular and Cellular Mechanisms to New Approaches

edited by Elia Ranzato

submission deadline 20 Jul 2026 | Viewed by 32 | Submission Open

Keywords: wound repair; tissue regeneration; molecular mechanisms; cellular mechanisms; chronic wounds; fibrosis/scarring; biomaterials; stem cells; translational therapies

(This special issue belongs to the Section Molecular Medicine)

Signaling Pathways of 5-HT Receptors in Neuropsychiatric Disorders

edited by

Abdeslam Chagraoui

and

Philippe De Deurwaerdère

submission deadline 20 Jul 2026 | Viewed by 27 | Submission Open

Keywords: serotonin; 5-HT Receptors; allostery; allosteric modulators; synaptic plasticity; psychedelics; non-hallucinogenic agonists; RNA editing; Akt; GSK3; ERK; PI3K; mTOR; microglia; neuroinflammation; dopamine; glutamate; prefrontal cortex; hippocampus; nucleus accumbens; depression; schizophrenia; anxiety; addictions; cognition; biosensors; cryo-EM; phospho-proteomics

(This special issue belongs to the Section Molecular Medicine)

Multi-Scale Integrative Radiobiology

edited by

Nicolas Foray

submission deadline 20 Jul 2026 | Viewed by 20 | Submission Open

Keywords: integrative radiobiology; radiosensitivity; radiosusceptibility; radiodegeneration; radiation-induced energy microdepositions; radiation-induced radical oxygen species; radiation-induced DNA damage; DNA damage recognition and repair; radiation-induced tissue injuries; radiation-induced risks

(This special issue belongs to the Section Molecular Biology)

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 24 Jul 2026 | Viewed by 224 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition

edited by

Clement Agoni

and

Indrani Bera

submission deadline 24 Jul 2026 | Viewed by 76 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein– protein interactions; protein– ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

New Insights into Integrins: 2nd Edition

edited by

Yoshikazu Takada

submission deadline 25 Jul 2026 | Viewed by 4 | Submission Open

Keywords: integrins; growth factors; ligands; allosteric binding; inflammation-induced activation

(This special issue belongs to the Section Biological Factors)

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 30 Jul 2026 | Viewed by 167 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Biomarkers in Musculoskeletal and Orthopedic Disorders

edited by

Elena De Vecchi

submission deadline 30 Jul 2026 | Viewed by 37 | Submission Open

Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis

(This special issue belongs to the Section Molecular Biomarkers)

The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 31 Jul 2026 | 3 articles | Viewed by 11507 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2251 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition

edited by

Grzegorz Janusz

and

Anna Pawlik

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1631 | Submission Open

Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering

(This special issue belongs to the Section Enzymology)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1004 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanisms of Skeletal Muscle Growth and Loss in Health, Aging, and Disease

edited by

Khaled Kamal

submission deadline 31 Jul 2026 | Viewed by 287 | Submission Open

Keywords: skeletal muscle; muscle growth and atrophy; metabolic signaling (anabolic/catabolic); mechanotransduction; redox biology and oxidative stress; inflammation and immune signaling; obesity and metabolic disease; sarcopenia and aging; cachexia and neuromuscular disease; extracellular vesicles and exosomes

(This special issue belongs to the Section Molecular Biology)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 31 Jul 2026 | Viewed by 170 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Redox Dysregulation and Mitochondrial Adaptation in Kidney Disease

edited by

Liang-Jun Yan

submission deadline 31 Jul 2026 | Viewed by 167 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; diabetic kidney disease; redox imbalance; reductive stress; reactive oxygen species; oxidative stress; mitochondrial stress response and adaptation; mitochondrial abnormalities; mitochondrial homeostasis; mitophagy; unfolded protein response

Therapeutics Targeting Pathogenic Mechanisms of Leishmaniasis

edited by

Kwang Poo Chang

submission deadline 31 Jul 2026 | Viewed by 159 | Submission Open

Keywords: leishmaniasis; host– parasite interactions; pathogenicity; precision medicine; AI-assisted development of therapeutics

LDL Receptor Family in Metabolic Homeostasis, Neurodevelopmental Disorders, and Signaling Pathways

edited by

María-Paz Marzolo

submission deadline 31 Jul 2026 | Viewed by 152 | Submission Open

Keywords: LDL receptor family; lipid metabolism; cholesterol homeostasis; neurodevelopmental and neuropsychiatric disorders; neurodegeneration; receptor-mediated endocytosis; Wnt and reelin signaling pathways; apolipoproteins; Alzheimer's disease; Parkinson's disease

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 31 Jul 2026 | Viewed by 146 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

Design and Applications of 3D Bioprinting

edited by

Saman Naghieh

and

Chaozong Liu

submission deadline 31 Jul 2026 | Viewed by 121 | Submission Open

Keywords: 3D bioprinting; biofabrication; tissue engineering; regenerative medicine; smart biomaterials; scaffold design; organ models; personalized therapeutics; biomedical additive manufacturing; translational bioprinting

(This special issue belongs to the Section Bio-Engineered Materials)

Heterocyclic Compounds: Synthesis, Characterization, and Validation

edited by

Monika Pitucha

submission deadline 31 Jul 2026 | Viewed by 114 | Submission Open

Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

Hepatic Stellate Cells and Immune Microenvironment in Hepatocellular Carcinoma

edited by

Tai-long Pan

submission deadline 31 Jul 2026 | Viewed by 86 | Submission Open

Keywords: hepatic stellate cell; hepatocellular carcinoma; immune microenvironment; extracellular matrix; epigenetics; tumor microenvironment; inflammation

(This special issue belongs to the Section Molecular Medicine)

Mutagenesis and Genetic Instability in Genome Evolution and in Cancer: Mechanisms, Consequences, and Therapeutic Perspectives

edited by

Said Aoufouchi

and Rabii Ameziane El Hassani

submission deadline 31 Jul 2026 | Viewed by 49 | Submission Open

Keywords: genomic instability; mutagenesis; evolution; genetic diversification DNA repair; epigenetic; cancers; therapy resistance

(This special issue belongs to the Section Molecular Biology)

DNA Replication Stress Tolerance Mechanisms: From Nucleoside Analog Repair to Therapeutic Strategies

edited by

Kouji Hirota

and Ryotaro Kawasumi

submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open

Keywords: nucleoside analogs; DNA replication; DNA damage tolerance; DNA repair; DNA damage checkpoint; targeted cancer therapy

(This special issue belongs to the Section Molecular Genetics)

Significance of KEAP1 and NRF2 Protein-Protein Interactions in Cancer

edited by

Mihaela Matovina

submission deadline 31 Jul 2026 | Viewed by 27 | Submission Open

Keywords: cancer; protein– protein interactions (PPIs); KEAP1; NRF2

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 31 Jul 2026 | Viewed by 20 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Tracking Aging and Stress: Omics-Based Insights into Physiology and Pathology

edited by

Dominika Drulis-Fajdasz

submission deadline 31 Jul 2026 | Viewed by 7 | Submission Open

Keywords: genetic proteomic; lipidomic metabolomic; aging senescence; neurodegeneration; cellular stress

(This special issue belongs to the Section Biological Factors)

Exploration of Drug Targets for Liver Fibrosis Based on Hepatic Stellate Cells and Extracellular Matrix Remodeling

edited by

Nadezda Apostolova

submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open

Keywords: liver fibrosis; collagen; hepatic stellate cells; senescence; animal models; extracellular matrix; hepatitis; cytokines; biomarkers; MASH; MASLD; cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Medicine)

Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors

edited by

Hewang Lee

and

Pedro A. José

submission deadline 14 Aug 2026 | Viewed by 237 | Submission Open

Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1910 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

edited by

Rui Li

and Xinmin Li

submission deadline 20 Aug 2026 | Viewed by 78 | Submission Open

Keywords: multiomics and bioinformatics; functional genomics; molecular breeding; molecular plant biology; functional genomics; sustainable agricultural biotechnology; nutrition and health of functional foods

(This special issue belongs to the Section Molecular Genetics)

Applications of Biomaterials in Medicine and Healthcare

edited by