Mechanisms of RNA Regulation in Inflammation

Dear Colleagues,

Inflammation is a multifaceted physiological response to infections, autoimmune disorders, allergies, metabolic imbalances, and physical injuries. While it plays an essential role in immune defense and tissue repair, chronic or uncontrolled inflammation contributes to various diseases, necessitating precise regulatory mechanisms for equilibrium. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as key regulators of inflammation at transcriptional, post-transcriptional, and epigenetic levels. Recent research highlights the role of ncRNAs in both fostering and resolving inflammation. Their dysregulation has been implicated in various inflammatory diseases such cardiovascular disease, osteoarthritis, sepsis, chronic obstructive pulmonary disease (COPD), asthma, acute lung injury, diabetic retinopathy, and neuroinflammatory disorders. Given their regulatory functions, ncRNAs are promising biomarkers for early disease detection and therapeutic targets for intervention. Advances in sequencing and bioinformatics have facilitated the identification of ncRNA signatures associated with inflammatory diseases. This Special Issue aims to explore the latest developments in ncRNA research related to inflammatory diseases, with a particular emphasis on biomarker discovery and innovative therapeutic approaches. By elucidating the complex interactions between ncRNAs and inflammatory pathways, we can pave the way for more precise and effective treatments for inflammation-associated disorders.

Dr. Roopa Biswas
Guest Editor

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