Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 20
Special Issue Editor
Interests: trefoil family peptides (Tffs); gut-liver-brain axis; animal model of Tff3 deficiency; metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases pose a major and escalating burden on global public health. Besides diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis, recent data underline cancer as a metabolic mitochondrial disease, urging a reconsideration of treatment options.
Systemic metabolic homeostasis begins with proper nourishment and function of the gastrointestinal tract (GI). Dysregulation of GI function leads to a vicious cycle of disruptions in cellular and systemic metabolic homeostasis, resulting in severe complications and increased morbidity.
In recent years, research has increasingly focused on the role of endogenous protective biomolecules—including adipokines, hepatokines, myokines, and various bioactive lipids and peptides—that can counteract metabolic stress, inflammation, and cellular damage.
Understanding the precise functions and underlying mechanisms of these molecules, such as their involvement in insulin sensitisation, lipid metabolism, and mitochondrial function, opens promising avenues for therapeutic intervention.
This Special Issue invites original research articles, reviews, and perspectives that explore the identification, regulation, and mechanistic actions of protective biomolecules in different metabolic diseases. Contributions highlighting novel signalling pathways, their roles in inter-organ communication, or translational potential as biomarkers or therapeutic targets are particularly encouraged.
Dr. Mirela Baus Lončar
Guest Editor
Manuscript Submission Information
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Keywords
- protective biomolecules
- metabolic homeostasis
- insulin resistance
- insulin resistance
- insulin resistancecancer metabolism
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