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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Signal Peptides in Health and Disease: Molecular Mechanisms and Therapeutic Potential

edited by

Renata Perlikowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 980 | Submission Open

Keywords: signal peptides; protein targeting; protein trafficking; therapeutic peptides; synthetic signal peptides; signal recognition particle; drug delivery system; biomarker discovery

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Therapies, Diagnostic Approaches, and Mechanistic Insights in Allergic Diseases

edited by

Roxana Silvia Bumbãcea

submission deadline 31 Aug 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: allergic diseases; allergological work-up; component-resolved diagnosis; biomarkers; endotypes and phenotypes; asthma; atopic dermatitis; chronic urticaria; food allergy; drug hypersensitivity; immunotherapy; biologic therapies; precision medicine

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Mechanisms of Normal and Malignant Hematopoiesis: 2nd Edition

edited by

Myunggon Ko

submission deadline 31 Aug 2026 | Viewed by 699 | Submission Open

Keywords: hematopoietic stem cells; self-renewal; differentiation; hematological malignancies; molecular mechanisms; genetic factors; epigenetic factors; transcriptional regulation; HSC niche; targeted therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

The Renin Angiotensin System: From Physiology to Novel Therapeutics

edited by Amanda J. Miller and

Yumei Feng Earley

submission deadline 31 Aug 2026 | 1 articles | Viewed by 613 | Submission Open

Keywords: renin-angiotensin system; physiology; neural control; translational therapeutics

(This special issue belongs to the Section Molecular and Translational Medicine)

The Pleiotropic Effects of Statins: Anti-Inflammatory, Anti-Coagulant, and Anti-Proliferative Properties

edited by

Maria Grau

submission deadline 31 Aug 2026 | Viewed by 545 | Submission Open

Keywords: hydroxymethylglutaryl-CoA reductase inhibitors; pharmacoepidemiology; anti-inflammatory properties; anti-coagulant properties; anti-proliferative properties

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in 3D Printing for Drug Delivery Systems

edited by

Ion-Bogdan Dumitrescu

, Cristina Manuela Drăgoi and Alina Crenguța Nicolae

submission deadline 31 Aug 2026 | Viewed by 526 | Submission Open

Keywords: 3D printing; drug delivery systems; personalized medicine; pharmaceutical engineering; controlled release

(This special issue belongs to the Section Biomedical Engineering and Materials)

MASH and Hepatocellular Carcinoma (HCC)—2nd Edition

edited by

Feng He

Ruirui Wang

and Xin Yang

submission deadline 31 Aug 2026 | Viewed by 520 | Submission Open

Keywords: MAFLD; MASH; HCC; obesity; inflammation; immunotherapy; stress

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research in Mitochondrial Medicine and Nanomedicine

edited by

Agnieszka Pyrczak-Felczykowska

submission deadline 31 Aug 2026 | Viewed by 485 | Submission Open

Keywords: nanomedicine; nanoparticles; drug delivery; mitochondria; cancer; neurodegenerative disease; metabolism; targeted therapy; mitochondrial function; bioactive compounds

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Advancements in Research on Pancreatic Cancer: From Biomarkers to Targeted Therapies

edited by

Konstantinos Dimas

submission deadline 31 Aug 2026 | Viewed by 473 | Submission Open

Keywords: pancreatic cancer; novel biomarkers; diagnostic techniques; therapeutic approaches

(This special issue belongs to the Section Cancer Biology and Oncology)

Feature Review: Advanced Manufacturing, Biomaterials, and Stem Cells for Tissue and Regenerative Engineering

edited by

Roozbeh Ross Salary

submission deadline 31 Aug 2026 | Viewed by 465 | Submission Open

Keywords: advanced manufacturing; biomaterials; tissue engineering; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

New Advances in Neuroprotective Agents

edited by

Mariano Catanesi

submission deadline 31 Aug 2026 | Viewed by 435 | Submission Open

Keywords: mitochondrial disfunction; antioxidant molecules; gene therapy; stem cell; nanomedicine; cellular reprogramming

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nanoparticles for Glioblastoma Therapy

edited by Shambhavi Pandey and

Benjamí Oller-Salvia

submission deadline 31 Aug 2026 | Viewed by 391 | Submission Open

Keywords: nanoparticles; blood– brain barrier; gene delivery; glioblastoma; cancer stem cells; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Intestinal Homeostasis and Disease Dysbiosis

edited by

Nikolas Dovrolis

submission deadline 31 Aug 2026 | Viewed by 371 | Submission Open

Keywords: gut microbiota; intestinal homeostasis; dysbiosis; microbiota–drug interactions; host–microbe interactions; microbiome therapeutics; precision medicine

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Research in Sarcopenia

edited by

Claudio Cabello-Verrugio

submission deadline 31 Aug 2026 | Viewed by 363 | Submission Open

Keywords: aging and muscle deterioration; secondary sarcopenia; metabolic diseases and sarcopenia; pathogen-induced muscle alterations; chronic disease-associated muscle loss; inflammatory sarcopenia mechanisms; sarcopenia biomarkers and diagnosis; therapeutic interventions; exercise and sarcopenia; muscle wasting syndromes; age-related frailty

(This special issue belongs to the Section Molecular and Translational Medicine)

Engineering Extracellular Matrix (ECM)-Based Scaffold Biomaterials for Cancer Treatment

edited by

Sanjay Pal

submission deadline 31 Aug 2026 | Viewed by 357 | Submission Open

Keywords: extracellular matrix; biomaterials; immunomodulatory agents; cancer immunotherapy; sustained delivery; drug delivery; tumor modeling; 3D model; therapeutic response; decellularized ECM

(This special issue belongs to the Section Gene and Cell Therapy)

Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma

edited by Julia Federspiel,

Teresa Steinbichler

and

Jozsef Dudas

submission deadline 31 Aug 2026 | Viewed by 353 | Submission Open

Keywords: head and neck oncology 3D tumor models; cancer-associated fibroblasts; phototherapy; exosomes

(This special issue belongs to the Section Cancer Biology and Oncology)

Antibody Responses to Viral Infections: Insights from Structural Biology

edited by Pragati Agnihotri and

Sharanbasappa Karade

submission deadline 31 Aug 2026 | Viewed by 353 | Submission Open

Keywords: crystal structure; virus–antibody complexes; broadly neutralizing antibodies; immunology; epitope mapping

(This special issue belongs to the Section Microbiology in Human Health and Disease)

From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications

edited by

Cristina Barale

submission deadline 31 Aug 2026 | Viewed by 346 | Submission Open

Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Chondrocyte Biology (2nd Edition)

edited by

Bo Qiu

submission deadline 31 Aug 2026 | Viewed by 325 | Submission Open

Keywords: osteoarthritis; chondrocyte; differentiation; proliferation; signaling pathways; transcription factor; inflammation; cellular processes; cartilage repair

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Fabry Disease: From Molecular Insights to Innovative Therapeutics (2nd Edition)

edited by

Yuri Battaglia

submission deadline 31 Aug 2026 | Viewed by 314 | Submission Open

Keywords: Fabry disease; lysosomal storage disorder; GLA gene mutations; enzyme replacement therapy; chaperone therapy; physical activity; imagining

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Head and Neck Squamous Cell Carcinoma

edited by Sagar Kansara and

Vlad Sandulache

submission deadline 31 Aug 2026 | Viewed by 308 | Submission Open

Keywords: head and neck cancer; head and neck squamous cell carcinoma; immunotherapy; multi-omics; machine learning; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Precision Diagnosis, Novel Mechanisms and Targeted Therapy for Autoimmune Encephalitis

edited by

Sheng Chen

submission deadline 31 Aug 2026 | Viewed by 307 | Submission Open

Keywords: autoimmune encephalitis; neuronal autoantibodies; biomarkers; animal models; immunopathogenesis; PET/MRI; immunotherapy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Tumor Immune Microenvironment and Immune Escape Mechanisms in Cancer Progression and Therapy

edited by Yadong Guo

submission deadline 31 Aug 2026 | Viewed by 285 | Submission Open

Keywords: tumor immune evasion; immune checkpoint regulation; tumor microenvironment; immunotherapy response and prognosis

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovative Anticancer Agents: Design, Synthesis and Pharmacological Evaluation

edited by

Sreenivasan Sasidharan

submission deadline 31 Aug 2026 | Viewed by 272 | Submission Open

Keywords: anticancer agents; drug design; pharmacological evaluation; structure–activity relationship; molecular docking; apoptosis; phytochemicals; oxidative stress; targeted therapy; natural products

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Oncolytic Viruses and Combinatorial Immunotherapy for Cancer (2nd Edition)

edited by

Zong Sheng Guo

and

Michael H. Lehmann

submission deadline 31 Aug 2026 | Viewed by 272 | Submission Open

Keywords: oncolytic virus; antitumor immunity; cold tumor; tumor antigen; cancer vaccine; immunotherapy; combinatorial therapy; immune checkpoint blockade

(This special issue belongs to the Section Immunology and Immunotherapy)

Innovative Approaches to Molecular Pathogenesis and Therapy of Lymphoid Malignancies: 2nd Edition

edited by

Sara Elgamal

and

Dalia El-Gamal

submission deadline 31 Aug 2026 | Viewed by 262 | Submission Open

Keywords: lymphoma; leukemia; myeloma; lymphoproliferative disorders; B-cell neoplasms; T-cell neoplasms; pathogenesis; molecular targets; novel therapies; translational research; tumor microenvironment

(This special issue belongs to the Section Cell Biology and Pathology)

CAR T-Cell Therapy in Solid Tumors

edited by

Luigi Liguori

submission deadline 31 Aug 2026 | Viewed by 233 | Submission Open

Keywords: CAR T cell; combinatorial strategies; immunotherapy; resistance; solid tumors; tumor microenvironment; tumor antigen

(This special issue belongs to the Section Cancer Biology and Oncology)

Brain Tumors: From Pathophysiology to Novel Diagnostic and Therapeutic Approaches

edited by Emma van Kessel, Sharon Berendsen and Pierre A. Robe

submission deadline 31 Aug 2026 | Viewed by 195 | Submission Open

Keywords: brain tumors; glioma; brain metastases; neuro-oncology; cognition; liquid biopsy; biomarkers; tumor biology; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research in Metabolic Syndrome (2nd Edition)

edited by

Balazs Varga

submission deadline 11 Sep 2026 | 4 articles | Viewed by 7177 | Submission Open

Keywords: obesity; diabetes; dyslipidemia; hypertension; microcirculatory damage; ischemia–reperfusion; necro-apopto-autophagy; laboratory animals; bioactive agents

(This special issue belongs to the Section Cell Biology and Pathology)

Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research to Clinical Applications

edited by

Laura Georgiana Necula

submission deadline 11 Sep 2026 | 2 articles | Viewed by 4296 | Submission Open

Keywords: gastric cancer; tumor microenvironment; gastric cancer metastasis; cancer stem cells; diagnosis and treatment; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges (2nd Edition)

edited by

M. R. Mozafari

submission deadline 15 Sep 2026 | 2 articles | Viewed by 9645 | Submission Open

Keywords: 3D/4D bioprinting techniques; 3D bioprinting processes; 3D cellular microenvironment; bio-inks; hydrogels

(This special issue belongs to the Section Biomedical Engineering and Materials)

Prostate Cancer Pathology: Recent Advances and Future Perspectives

edited by

Kostis Gyftopoulos

submission deadline 15 Sep 2026 | 3 articles | Viewed by 5174 | Submission Open

Keywords: prostate cancer; pathology; digital pathology; Gleason grading; molecular biomarkers; precision medicine; molecular pathology; molecular profiling; therapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

New Perspectives in the Treatment of Head and Neck Vascular Malformations

edited by Paolo Gennaro

submission deadline 18 Sep 2026 | 1 articles | Viewed by 3417 | Submission Open

Keywords: vascular anomalies; vascular malformations; AVMs; venous malformations; electrosclerotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Cancer: Biomarkers, Therapeutic Strategies and Future Directions

edited by Nedime Serakinci

submission deadline 25 Sep 2026 | 3 articles | Viewed by 2387 | Submission Open

Keywords: cancer biomarkers; stem cells; personalized medicine; emerging cancer therapies; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Obstructive Sleep Apnea: Mechanisms, Comorbidities, and Optimization of Emerging and Established Therapies

edited by

Ivana Pavlinac Dodig

and

Renata Pecotic

submission deadline 29 Sep 2026 | 11 articles | Viewed by 20186 | Submission Open

Keywords: obstructive sleep apnea; sleep-disordered breathing; pathophysiology; cardiometabolic comorbidities; precision medicine; CPAP; sleep diagnostics; biomarkers; neurocognitive impairment; new therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications

edited by Zhekai Hu

submission deadline 29 Sep 2026 | 3 articles | Viewed by 3171 | Submission Open

Keywords: bone tissue engineering; craniofacial regeneration; biomaterials and scaffolds; stem cells and exosomes; mechanobiology and orthodontic forces; osteoimmunology; oxidative stress modulation; gene/drug delivery; translational research; periodontal and alveolar bone regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pathology, Complications and Prognosis of Type 1 Diabetes

edited by Maurizio Delvecchio

submission deadline 29 Sep 2026 | 1 articles | Viewed by 1680 | Submission Open

Keywords: type 1 diabetes mellitus; autoimmune β-cell destruction; diabetic complications; microvascular and macrovascular damage; diabetic ketoacidosis; glycemic control; disease prognosis; immunopathogenesis

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Nervous System Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Natalia Rozas and Cameron Jeter

submission deadline 30 Sep 2026 | 9 articles | Viewed by 34938 | Submission Open

Keywords: neurodegenerative diseases; neuromuscular diseases; autoimmune diseases of the nervous system; brain diseases; neuroinflammatory diseases; neuromuscular diseases; trauma of the nervous system

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Diabetes: Comorbidities, Therapeutics and Insights (3rd Edition)

edited by

Tomislav Bulum

submission deadline 30 Sep 2026 | 9 articles | Viewed by 22236 | Submission Open

Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Nephrotic Syndrome: Pathomechanism, Diagnostics and Novel Treatment Options—2nd Edition

edited by

Kan Katayama

submission deadline 30 Sep 2026 | 5 articles | Viewed by 18618 | Submission Open

Keywords: focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular and Translational Medicine)

Hypertension and Chronic Renal Failure

edited by

Caterina Carollo

submission deadline 30 Sep 2026 | 4 articles | Viewed by 17273 | Submission Open

Keywords: hypertension; chronic renal failure; NephroCardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Parkinson’s Disease: Where Are We and Where Are We Going To

edited by Carmen Borrué

submission deadline 30 Sep 2026 | 1 articles | Viewed by 17120 | Submission Open

Keywords: Parkinson’s disease; gait disorders; biomarkers; neurodegenerative disease; AI

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Gynecological Diseases in Cellular and Molecular Perspectives

edited by

Iwona Wertel

and

Anna Pawłowska-Łachut

submission deadline 30 Sep 2026 | 7 articles | Viewed by 16196 | Submission Open

Keywords: gynaecological diseases; endometriosis; biomarkers; immune checkpoints; immunotherapy; tumor microenvironment; tumor-infiltrating immune cells; cancer immunology; cellular interactions

(This special issue belongs to the Section Molecular and Translational Medicine)

Role of Glycomics in Health and Diseases

edited by

Tijl Vermassen

submission deadline 30 Sep 2026 | 4 articles | Viewed by 15579 | Submission Open

Keywords: glycomics; protein chemistry; immunology; biomarker research

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements in the Treatment of Colorectal Cancer

edited by

Andee Dzulkarnaen Zakaria

submission deadline 30 Sep 2026 | 8 articles | Viewed by 14093 | Submission Open

Keywords: genomic profiling; advanced nutritional support; AI; MDT; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Chronic Kidney Disease: Biology, Diagnosis and Therapy (3rd Edition)

edited by

Susana Coimbra

and

Alice Santos-Silva

submission deadline 30 Sep 2026 | 11 articles | Viewed by 11893 | Submission Open

Keywords: inflammation; kidney biomarkers; kidney injury; chronic kidney disease; dialysis; cardiorenal syndrome risk; CKD anemia; kidney physiopathology; CKD treatment

(This special issue belongs to the Section Cell Biology and Pathology)

The Molecular Basis of the Immune Response in Pulmonary Fibrosis

edited by

Tamara Cruz

and

Fernanda Hernandez

submission deadline 30 Sep 2026 | 3 articles | Viewed by 11000 | Submission Open

Keywords: immune response; fibrosis; aging; senescence

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Research in Ocular Pathology

edited by

Sorin Lucian Bolintineanu

and

Laura Andreea Ghenciu

submission deadline 30 Sep 2026 | 5 articles | Viewed by 10823 | Submission Open

Keywords: molecular pathology; ocular diseases; biomarkers; diabetic retinopathy; glaucoma; age-related macular degeneration; thyroid eye disease; inflammatory pathways; oxidative stress; angiogenesis; neurodegeneration; gene therapy; cell therapy; precision medicine; ocular imaging

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Neonatal Medicine in Japan

edited by

Fumihiko Namba

submission deadline 30 Sep 2026 | 4 articles | Viewed by 10388 | Submission Open

Keywords: mesenchymal stromal cells; artificial placenta; therapeutic gasses; animal models; off-label drug use

(This special issue belongs to the Section Molecular and Translational Medicine)

Skin Diseases and Cell Therapy

edited by Nives Pondeljak, Maryam Heidari Kharaji and Mirna Šitum

submission deadline 30 Sep 2026 | 3 articles | Viewed by 9547 | Submission Open

Keywords: dermatology; psoriasis, atopic dermatitis, vitiligo, alopecia, cutaneous leishmaniasis, and skin fibrosis; skin cancers; innovative therapeutic strategies; molecular mechanisms

(This special issue belongs to the Section Gene and Cell Therapy)

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