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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovations and Prospects in Single Cell RNA-seq for Biomedical Research

edited by

Hui-Qi Qu

submission deadline 30 Sep 2025 | Viewed by 430 | Submission Open

Keywords: bioinformatics; cellular heterogeneity; methodology; molecular biology; single-cell RNA sequencing; single-nucleus RNA sequencing; tissue heterogeneity; transcriptomics

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advanced Research on the Role of Biogenic Amines in Physiological and Pathological Conditions

edited by

Pellegrino Lippiello

Luisa Speranza

and

Maria Grazia Ferraro

submission deadline 30 Sep 2025 | Viewed by 426 | Submission Open

Keywords: biogenic amines; memory; synapse; depression; anxiety; schizophrenia; glioma and neurodegenerative diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Eosinophil: Current Status and Future Perspectives

edited by

Ildiko Horvath

submission deadline 30 Sep 2025 | Viewed by 408 | Submission Open

Keywords: eosinophils; predictive biomarker; severe asthma; blood cell count; anti-eosinophils; mortality

(This special issue belongs to the Section Cell Biology and Pathology)

The Role of the Myofibroblast in Fibrosis and Cancer

edited by Bingrui Li, Xuebin Fu, Xiaodong Zou and Xue Wan

submission deadline 30 Sep 2025 | Viewed by 407 | Submission Open

Keywords: fibroblasts and myofibroblasts; fibrosis (organ and tissue fibrosis); cancer; tissue injury; extracellular matrix

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Neuropharmacology

edited by

Yu-Cheng Ho

and

Ming Tatt Lee

submission deadline 30 Sep 2025 | Viewed by 396 | Submission Open

Keywords: behavioral neuropharmacology; molecular neuropharmacology; neuropharmacology; neurological disorders; neurodegenerative diseases

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Diagnostic and Therapeutic Challenges of CAR-T Cell Therapy

edited by Vincenzo Maria Perriello

submission deadline 30 Sep 2025 | Viewed by 383 | Submission Open

Keywords: CAR-T therapy; immunotherapy; relapsed/refractory diffuse large B cell lymphoma (r/r DLBCL); relapsed/refractory mantle cell lymphoma (r/r MCL); B-acute lymphoblastic leukemia (r/r B-ALL); bridging therapy; cytokine release syndrome (CRS); immune effector cell associated neurotoxicity (ICANS); biomarkers; PET/CT assessment after CAR-T cell therapy

(This special issue belongs to the Section Gene and Cell Therapy)

Advances in Drug Discovery and Development Using Mass Spectrometry

edited by Emily G. Werth,

Amirata Saei Dibavar

and Lin-Zhi Chen

submission deadline 30 Sep 2025 | 1 articles | Viewed by 350 | Submission Open

Keywords: LC/MS; proteomics; protein therapeutics; PTMs; immunocapture; CQAs

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Neuroscience Through Electrophysiology: Current Trends and Future Directions

edited by

Xiaokuang Ma

submission deadline 30 Sep 2025 | Viewed by 348 | Submission Open

Keywords: electrophysiology; neural circuit; synaptic plasticity; neuronal membrane; patch-clamp; action potential; ion channels; neurodevelopmental disorders; neurodegenerative disorders

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

DNA Methylation Profiling for the Classification and Diagnosis of Tumors

edited by

Valeria Barresi

submission deadline 30 Sep 2025 | Viewed by 319 | Submission Open

Keywords: DNA methylation; tumors; central nervous system; soft tissues; haematolymphoid tumors; diagnostic tool

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Applications of Mass Spectrometry-Based Methods to Explore the Impact of Circadian Rhythms on Disease

edited by Robin Joshi

submission deadline 30 Sep 2025 | Viewed by 309 | Submission Open

Keywords: circadian biology; metabolomics; multiomics; method development; circadian biology; mass spectrometry; proteomics and post-translational modifications in disease; translational medicines; chronopharmacology

(This special issue belongs to the Section Biomedical Engineering and Materials)

Roles of Extracellular Vesicles in the Complex Interaction Between Metabolic Disorder and Cancer

edited by

Keyang Xu

submission deadline 30 Sep 2025 | Viewed by 304 | Submission Open

Keywords: extracellular vesicles; metabolic disorders; obesity; diabetes; cardiovascular diseases; cancer; mechanism; diagnosis; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Immunogenetic Regulations for Disease Prognosis

edited by Anshuman Mishra and

Trim Lajqi

submission deadline 30 Sep 2025 | Viewed by 295 | Submission Open

Keywords: immunity; host susceptibility; gene expression; biotechnology; disease resistance; immunogenicity; drug monitoring; vaccines; adaptive immunity

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Skin Fibrosis and Cutaneous Wound Healing—2nd Edition

edited by

Noriko Aramaki-Hattori

submission deadline 30 Sep 2025 | Viewed by 262 | Submission Open

Keywords: fibroblasts; inflammation; fibrosis; cutaneous wound healing

(This special issue belongs to the Section Molecular and Translational Medicine)

Immune Checkpoint Molecules and Cancer Immunotherapy

edited by Zhiyuan Qin and Shujing Liu

submission deadline 30 Sep 2025 | Viewed by 257 | Submission Open

Keywords: immune checkpoint molecules; cancer immunity; tumor immune microenvironment; cancer immunotherapy; biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

State-of-the-Art Dermatology in Spain

edited by

Francisco José Navarro-Triviño

and

Ricardo Ruiz-Villaverde

submission deadline 30 Sep 2025 | Viewed by 244 | Submission Open

Keywords: dermatological research; dermatology; skin disease; psoriasis; atopic dermatitis; urticaria; alopecia areata

(This special issue belongs to the Section Molecular and Translational Medicine)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 30 Sep 2025 | Viewed by 234 | Submission Open

Keywords: mycobacterium; pathogenesis; host– pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Bone Diseases: Pathophysiology and Molecular Biology

edited by

Tommaso Greco

Carlo Perisano

and Nicola De Gasperis

submission deadline 30 Sep 2025 | Viewed by 209 | Submission Open

Keywords: bone diseases; osteoporosis; osteoarthritis; Paget’ s disease; bone tumors

(This special issue belongs to the Section Molecular and Translational Medicine)

Oxidative Stress, Inflammation and Endothelial Dysfunction in COVID-19 Era and Long COVID-19 Complications

edited by

Ekaterina Georgieva

submission deadline 30 Sep 2025 | Viewed by 188 | Submission Open

Keywords: oxidative stress; redox-disbalance; COVID-19; post-COVID-19; cytokines; mitochondrial dysfunction; endothelial damages; ROS and RNS; thrombosis; antioxidant therapy; oxidative shock

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Gastroenterology and Hepatology: Special Focus on Microvesicles

edited by Fabrizio Pizzolante

submission deadline 30 Sep 2025 | Viewed by 187 | Submission Open

Keywords: cirrhosis; hepatocellular carcinoma; metabolic-associated fatty liver disease; inflammatory bowel disease; liquid biopsy; microvescicals

(This special issue belongs to the Section Cell Biology and Pathology)

Interdisciplinary Perspectives on Protein Glycosylation, Signaling, and Toxicity in Biological Systems

edited by Ashutosh Pandey

submission deadline 30 Sep 2025 | Viewed by 185 | Submission Open

Keywords: glycosylation; signaling pathways; toxicity; environmental chemicals; animal models

(This special issue belongs to the Section Cell Biology and Pathology)

Innovations and Perspectives in Kidney Transplantation

edited by Vassilis Filiopoulos

submission deadline 30 Sep 2025 | 1 articles | Viewed by 172 | Submission Open

Keywords: bioartificial kidney; immunology; immunosuppression; kidney transplantation; tolerance; graft rejection; graft survival; xenotransplantation; kidney regeneration

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular and Cellular Mechanisms of Cardiovascular Diseases: 2nd Edition

edited by

Antonella Galeone

submission deadline 30 Sep 2025 | Viewed by 169 | Submission Open

Keywords: hypertension; diabetes; coronary heart disease; valvular heart disease; infective endocarditis; aortic dissection; aortic aneurysm; heart failure; cardiomyopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Extracellular Vesicles in Therapeutics

edited by

Mangesh D. Hade

and

Akil Akhtar

submission deadline 30 Sep 2025 | Viewed by 165 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; regenerative medicine; immunotherapy; nanocarriers; biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Biomaterials for Bone Regeneration: 2nd Edition

edited by

Kyeong-Hyeon Park

submission deadline 30 Sep 2025 | 1 articles | Viewed by 158 | Submission Open

Keywords: bone regeneration; bone defect; induced membrane technique; bone transport; biomaterials

(This special issue belongs to the Section Biomedical Engineering and Materials)

Artificial Intelligence Applications in Cancer and Other Diseases—2nd Edition

edited by

Raji Sundararajan

submission deadline 30 Sep 2025 | Viewed by 152 | Submission Open

Keywords: artificial intelligence; machine learning; neural networks; deep learning; obesity; diabetes; cancer; other diseases; pathology; drug discovery

(This special issue belongs to the Section Biomedical Engineering and Materials)

Matrix Biology Insights: Unraveling the Role of Proteinases, Fibroblasts, and Extracellular Matrix Metalloproteinase Inducer in the Tumor Microenvironment

edited by

Eric Huet

submission deadline 30 Sep 2025 | Viewed by 147 | Submission Open

Keywords: tumor microenvironment; proteinases; fibroblasts; EMMPRIN; matrix biology; extracellular matrix (ECM); matrix metalloproteinases (MMPs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Endothelial Dysfunction

edited by

Manfredi Tesauro

submission deadline 30 Sep 2025 | Viewed by 146 | Submission Open

Keywords: endothelial dysfunction; atherosclerosis; nitric oxide (NO); hyperlipidemia; hypertension; hyperglycemia; vasodilation; perivascular adipose tissue (PVAT); insulin resistance

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Diagnostic and Therapeutic Approaches to Pancreatic Cancer—Second Edition

edited by

Sanchita Rauth

submission deadline 30 Sep 2025 | Viewed by 141 | Submission Open

Keywords: pancreatic cancer; systemic therapy; immunotherapy; tumor microenvironment; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Neuromuscular Diseases: Biochemical, Genetic, and Electrophysiological Studies

edited by

Vincenzo Macaione

submission deadline 30 Sep 2025 | Viewed by 124 | Submission Open

Keywords: neuromuscular disorders; motor neuron diseases; myopathies; neuropathies; autoimmune neuromuscular diseases; electromyography; nerve conduction studies; epigenomics; genomics; new therapeutic approaches; myasthenia; mitochondrial disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Cytogenetics in Health and Diseases

edited by

Rong Xiang

submission deadline 30 Oct 2025 | Viewed by 111 | Submission Open

Keywords: genetic mutations; high-throughput sequencing; genomics; multiomics; rare diseases

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Pathological Biomarkers in Precision Medicine

edited by

Ovidiu Constantin Baltatu

, Mirela A. Dobre and Tudor Groza

submission deadline 31 Oct 2025 | 7 articles | Viewed by 20436 | Submission Open

Keywords: pathological biomarkers; precision medicine; artificial intelligence; medical imaging; omics data analysis; personalized medicine; biomarker discovery; digital pathology

(This special issue belongs to the Section Cell Biology and Pathology)

Breast Cancer: New Diagnostic and Therapeutic Approaches

edited by

Erika Bandini

Tania Rossi

and Sara Bravaccini

submission deadline 31 Oct 2025 | 8 articles | Viewed by 17152 | Submission Open

Keywords: breast cancer; breast oncology; circulating tumor cells

(This special issue belongs to the Section Cancer Biology and Oncology)

Mechanisms and Pharmacological Targets for Pain

edited by Renan F. do Espírito-Santo

submission deadline 31 Oct 2025 | 4 articles | Viewed by 12854 | Submission Open

Keywords: drug discovery; chronic pain; inflammatory pain; mechanisms of action; pain pharmacology; immunomodulation; neuropathic pain

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Fetal Medicine and Neonatology

edited by

Robert Brawura-Biskupski-Samaha

submission deadline 31 Oct 2025 | 5 articles | Viewed by 11324 | Submission Open

Keywords: fetal medicine; neonatology; research innovations; perinatal care; clinical practices

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis, Diagnostics, and Therapeutics for Rheumatic Diseases

edited by Jixin Zhong

submission deadline 31 Oct 2025 | 12 articles | Viewed by 10400 | Submission Open

Keywords: rheumatic diseases; pathogenesis; autoimmunity; biomarkers; precision medicine; therapeutics; disease management; immunology; clinical diagnostics; treatment strategies

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Issues in Retinal Degeneration

edited by

Ponarulselvam Sekar

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9953 | Submission Open

Keywords: retinal degeneration; age-related macular degeneration (AMD); retinitis pigmentosa (RP); diabetic retinopathy; gene therapy; stem cell therapy; retinal implants; pharmacological treatments; diagnostic methods; molecular mechanisms; predictive biomarkers; imaging technologies; signaling pathways; oxidative stress; neuroprotection

(This special issue belongs to the Section Cell Biology and Pathology)

Feature Reviews in Gastrointestinal Diseases

edited by

Fu-Chen Huang

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9645 | Submission Open

Keywords: precision medicine; artificial intelligence; eosinophilic gastrointestinal diseases; inflammatory bowel disease; irritable bowel syndrome; gastroesophageal reflux disease; gastrointestinal cancers; drug-resistant infections

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Mechanisms of Steroid Hormone Action—2nd Edition

edited by

Omar Cauli

submission deadline 31 Oct 2025 | 4 articles | Viewed by 8551 | Submission Open

Keywords: oestrogen; androgens; thyroid; adrenal gland; menopause; cancer

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Maternal-Fetal and Neonatal Medicine

edited by

Dimitrios Papageorgiou

submission deadline 31 Oct 2025 | 2 articles | Viewed by 8433 | Submission Open

Keywords: maternal– fetal health; neonatal health; prenatal care; prenatal diagnosis; fetal growth; diabetes mellitus; hypertension; pre-eclampsia; congenital infections; gene therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Hypertrophic Cardiomyopathy

edited by Said Alsidawi,

Juan Farina

and

Celestino Sardu

submission deadline 31 Oct 2025 | 6 articles | Viewed by 8290 | Submission Open

Keywords: hypertrophic cardiomyopathy; myosin inhibitors; genetic therapy; risk stratification

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Tumors, 4th Edition

edited by

Silvia Di Agostino

and

Jan B. Vermorken

submission deadline 31 Oct 2025 | 6 articles | Viewed by 7989 | Submission Open

Keywords: head and neck tumors; predictive markers; liquid biopsy; therapy; precision medicine; biomaterials

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Research in Obesity, 2nd Edition

edited by Zaida Abad-Jiménez and

Teresa Vezza

submission deadline 31 Oct 2025 | 3 articles | Viewed by 7483 | Submission Open

Keywords: obesity; genetics; molecular pathways; adipose tissue; metabolism; leukocytes; prevention; new targets for treatment; translational studies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Genetic Research on Neuropsychiatric Disorders and Complex Human Diseases

edited by Wen Zhang

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6996 | Submission Open

Keywords: neuropsychiatric disorders; complex human diseases; genetic research; omics data analysis; high-throughput sequencing; machine learning; disease mechanism

(This special issue belongs to the Section Molecular and Translational Medicine)

Cell Signaling and Molecular Regulation in Neurodegenerative Disease

edited by Shao-Ming Wang

submission deadline 31 Oct 2025 | 2 articles | Viewed by 6929 | Submission Open

Keywords: neurological diseases; gene regulation; molecular neurobiology; neurodegenerative disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Pathogenesis and Novel Therapeutics in Musculoskeletal Conditions, 3rd Edition

edited by

Juan Antonio Valera-Calero

and

Gustavo Plaza-Manzano

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6731 | Submission Open

Keywords: neck pain; low back pain; myofascial pain syndromes; chronic pain; musculoskeletal disorders; disability; pain treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovative Approaches to Molecular Pathogenesis and Therapy of Lymphoid Malignancies

edited by

Dalia El-Gamal

and

Audrey Smith

submission deadline 31 Oct 2025 | 6 articles | Viewed by 6205 | Submission Open

Keywords: lymphoma; leukemia; myeloma; lymphoproliferative disorders; B-cell neoplasms; T-cell neoplasms; pathogenesis; molecular targets; novel therapies; translational research; tumor microenvironment

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research in Atrial Fibrillation

edited by

Wern Yew Ding

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6169 | Submission Open

Keywords: atrial fibrillation; arrhythmia; electrophysiology; cardiovascular; mechanism; laboratory; experimental

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Cardiovascular Drugs: In Memory of Professor Akira Endo

edited by

Alfredo Caturano

submission deadline 31 Oct 2025 | 7 articles | Viewed by 5914 | Submission Open

Keywords: cardiovascular drugs; statins; metformin; SGLT2i; laboratory; drug targets; translational research; targeted therapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Dualistic Equilibrium in Neurotransmission and Beyond: Unraveling the Pathophysiology and Unlocking Novel Therapeutic Targets in Neuropsychiatric Disorders—2nd Edition

edited by

Masaru Tanaka

and

Simone Battaglia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 5599 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; cognitive dysfunction; multiple sclerosis; stroke; migraine; chronic pain; depressive disorder; bipolar disorder; post-traumatic stress disorder; anxiety disorder; schizophrenia; somatic symptom disorder; autism spectrum disorder; hyperactive attention deficit disorder; learning disabilities; brain injuries; comorbidity; brain plasticity; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Novel Drug Discovery, Synthesis, and Evaluation

edited by

Khaled M. Elokely

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5151 | Submission Open

Keywords: drug synthesis; novel therapies; disease targets; medicinal chemistry; computational methods; screening techniques; pharmaceutical development; target identification

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

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