Gynecological Diseases in Cellular and Molecular Perspectives

Dear Colleagues,

Gynaecological diseases are a heterogeneous group of conditions of the female reproductive tract, including malignancies, benign tumors, endometriosis, polycystic ovarian syndrome, menstrual disorders, and others. It should be highlighted that they are not only the leading cause of women's mortality worldwide but also lead to significant deterioration in quality of life. Despite the development of new tools in the diagnosis and treatment of gynaecological diseases, the prognosis for patients remains poor, especially in ovarian cancer. In both early diagnosis and the treatment of gynaecological pathologies, it is necessary to investigate the molecular background to deepen the current knowledge and understanding of cellular interactions, including immune checkpoints (PD-1/PD-L1, TIGIT/CD155/DNAM-1, TIM-3/Gal-9 pathways etc.). Molecular profiling, including genomic profiling, microsatellite instability status, tumor mutational burden, immune/molecular biomarkers, and microRNAs, is also predominant for clinical management. The projecting of molecular and cellular biomarkers may lead to implementing molecular medicine in routine clinical practice to improve the outcomes and quality of life of gynecological patients. The goal of this Special Issue, “Gynecological diseases in cellular and molecular perspectives”, is to contribute to understanding the cellular and molecular mechanisms involved in the pathogenesis and progression of diseases of the female reproductive tract. All manuscripts will be published with the highest standards in publication ethics.

Prof. Dr. Iwona Wertel
Dr. Anna Pawłowska-Łachut
Guest Editors

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