Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pharmacogenetics and Pharmacogenomics: Driving Forces in Modern Precision Medicine
edited by Miriam Saiz-Rodríguez and Dora Koller
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1351 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; polygenic risk scores; phenoconversion; drug response; genetic biomarkers; personalized therapy; underrepresented populations; clinical implementation
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders
edited by Sukanta Jash
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR
(This special issue belongs to the Section Gene and Cell Therapy)
Molecular Signatures and Therapeutic Strategies in Urological Cancers
edited by Haoyue Sheng
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1266 | Submission Open
Keywords: urological cancers; molecular signatures; precision medicine; non-coding RNAs; tumor microenvironment
(This special issue belongs to the Section Molecular and Translational Medicine)
Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1261 | Submission Open
Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research
(This special issue belongs to the Section Molecular and Translational Medicine)
Pancreatic Cancer: From Mechanisms to Therapeutic Approaches (4th Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1167 | Submission Open
Keywords: pancreatic cancer; tumor microenvironment; biomarker; immune environment in pancreatic cancer
(This special issue belongs to the Section Cancer Biology and Oncology)
Gynecologic Research: New Diagnostic and Therapeutic Approaches
edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis
submission deadline 31 Oct 2026 | 1 articles | Viewed by 963 | Submission Open
Keywords: precision gynecology; liquid biopsy in gynecologic oncology; fertility preservation; gynecologic cancers; pelvic disorders; hormonal therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Cell-Based Immunotherapy: CAR-T Cells, CAR-NK and TCR-Engineered Cells submission deadline 31 Oct 2026 | 1 articles | Viewed by 883 | Submission Open
Keywords: CAR-T cell therapy; CAR-NK cell therapy; TCR-engineered cells; adoptive immunotherapy; chimeric antigen receptor; tumor immunology; cellular therapy; hematologic malignancies; immune cell engineering; oncology
(This special issue belongs to the Section Gene and Cell Therapy)
Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets
edited by Jude Taylor
submission deadline 31 Oct 2026 | Viewed by 877 | Submission Open
Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
3D Cell Culture Systems for Biomedical Research, 2nd Edition submission deadline 31 Oct 2026 | 1 articles | Viewed by 846 | Submission Open
Keywords: 3D; scaffolds; spheroids; biomaterials; tumour model; bioengineering; tissue regeneration; regenerative medicine; targeted therapies; tissue mimics; angiogenesis; cancerogenesis; drug development; 3D printing; material functionalisation
(This special issue belongs to the Section Biomedical Engineering and Materials)
Molecular Research in Genitourinary Oncology
edited by , Ioannis Zachos and Vassilios P. Tzortzis
submission deadline 31 Oct 2026 | 1 articles | Viewed by 839 | Submission Open
Keywords: genitourinary oncology; molecular biomarkers; genomics and epigenomics; tumor microenvironment; liquid biopsy
(This special issue belongs to the Section Cancer Biology and Oncology)
Emerging Trends in Dental Caries: Insights into Etiology, Risk Factors, and Treatment Strategies (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 783 | Submission Open
Keywords: antimicrobial effect; demineralization; dental caries; dental plaque; oral biofilm; oral disease; oral management; pathogenicity; prevention; remineralization
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Respiratory Infections: New Diagnostic and Therapeutic Approaches
edited by Aleksandar Sovtic
submission deadline 31 Oct 2026 | 1 articles | Viewed by 698 | Submission Open
Keywords: pneumonia; lower respiratory infections; respiratory microbiota; cystic fibrosis; pneumococcal disease; bronchiolitis; pertussis; biofilm
(This special issue belongs to the Section Molecular and Translational Medicine)
Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 637 | Submission Open
Keywords: prostate cancer; androgen deprivation therapy; molecular signaling; epigenetic remodeling; cancer stem cell; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders
edited by and
submission deadline 31 Oct 2026 | Viewed by 617 | Submission Open
Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut–brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Lymphomas: From Mechanisms to Therapeutic Approaches
edited by Delfa Radić-Krišto and
submission deadline 31 Oct 2026 | Viewed by 565 | Submission Open
Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas
(This special issue belongs to the Section Cancer Biology and Oncology)
Dopamine in Health and Disease (3rd Edition)
edited by
submission deadline 31 Oct 2026 | Viewed by 477 | Submission Open
Keywords: dopamine; disease models; mitochondria; Parkinson’s disease; schizophrenia
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cell-Based Immunotherapies: CAR-T, CAR-NK and TCR-Engineered Cells
edited by Min Zhou
submission deadline 31 Oct 2026 | 1 articles | Viewed by 453 | Submission Open
Keywords: adoptive cell therapy; CAR-T cells; CAR-NK cells; TCR-engineered T cells; in vivo CAR-T generation; allogeneic cell therapy; off-the-shelf cell therapy; gene editing (CRISPR); artificial intelligence-guided cell engineering; combination immunotherapy
(This special issue belongs to the Section Gene and Cell Therapy)
Current Challenges and Future Perspectives of Antimicrobial Therapy submission deadline 31 Oct 2026 | Viewed by 451 | Submission Open
Keywords: antibiotics; antifungals; antimicrobial resistance; antimicrobial stewardship; drug safety and efficacy; resistance mechanisms
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Post-Viral Syndromes and Long-Term Health Impacts
edited by Sophia X. Sui
submission deadline 31 Oct 2026 | Viewed by 407 | Submission Open
Keywords: post-viral syndrome; long COVID; ME/CFS; immune dysregulation; neuroinflammation; metabolism; biomarkers; therapeutic targets; basic research; translational research
(This special issue belongs to the Section Molecular and Translational Medicine)
Molecular Mechanisms of Cardiovascular Diseases (CVDs)
edited by
submission deadline 31 Oct 2026 | Viewed by 403 | Submission Open
Keywords: cardiovascular diseases (CVDs); molecular mechanisms; metabolic dysregulation; immunity; immunometabolism
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarkers and Precision Medicine in Gynecologic Malignancies
edited by Zheng Feng
submission deadline 31 Oct 2026 | Viewed by 389 | Submission Open
Keywords: clinical trials; genomic landscape; targeted therapy; liquid biopsy; tumor screening; biomarker research; artificial intelligence
(This special issue belongs to the Section Cancer Biology and Oncology)
Targeted Immunotherapy: Shared Targets and Technologies in Oncology and Autoimmune Disorders
edited by , Madalina Nistor and Dávid Kegyes
submission deadline 31 Oct 2026 | Viewed by 352 | Submission Open
Keywords: autoimmunity; targeted therapies; immune therapies; CAR T-cells; innate immunity
(This special issue belongs to the Section Immunology and Immunotherapy)
Cardiometabolic and Musculoskeletal Interactions: Molecular Mechanisms and Therapeutic Targets
edited by
submission deadline 31 Oct 2026 | Viewed by 347 | Submission Open
Keywords: cardiometabolic disease; metabolism; obesity; diabetes; cardiovascular function; ageing; bone biology; sarcopenia; organ crosstalk; cellular signaling; inflammation; oxidative stress; animal models; tissue engineering; therapeutic targets
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarkers in the Management of Ophthalmic Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 321 | Submission Open
Keywords: novel biomarkers; optical coherence tomography; artificial intelligence; molecular diagnostics; tear film analysis; retinal diseases; glaucoma; disease progression monitoring
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights into Mechanism of Breast Cancer Development and Resistance to Therapy
edited by
submission deadline 31 Oct 2026 | Viewed by 306 | Submission Open
Keywords: breast cancer; tumorigenesis; therapy resistance; endocrine resistance; HER2-targeted therapy resistance; molecular mechanisms; cancer genetics; NGS/next-generation sequencing; genomic alterations; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Targeting Ferroptosis in Neurological Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 292 | Submission Open
Keywords: iron; neurodegeneration; ferroptosis; glutathione peroxidase 4; lipid peroxidation; Alzheimer’s disease; Parkinson’s disease; traumatic brain injury; stroke; subarachnoid hemorrhage
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
State of the Art in Mitochondrial Research
edited by
submission deadline 31 Oct 2026 | Viewed by 287 | Submission Open
Keywords: mitochondrial metabolism; bioenergetics; mitochondrial signaling; mitochondrial dynamics; reactive oxygen species; apoptosis; hypoxia; mitochondrial genetics; mitochondrial diseases; aging
(This special issue belongs to the Section Cell Biology and Pathology)
Cellular Senescence: Heterogeneity, Mechanisms and Therapeutic Opportunities
edited by and Concepcion Peiro
submission deadline 31 Oct 2026 | Viewed by 277 | Submission Open
Keywords: cellular senescence; context-dependent senescence; tissue homeostasis; cardiovascular senescence; neurovascular senescence; cancer and therapy-induced senescence; senescence biomarkers; circulating senescence markers; senescence heterogeneity; cell-type-specific senescence; senolytics; senomorphics
(This special issue belongs to the Section Cell Biology and Pathology)
Drug Design via Structure–Activity Relationships
edited by Saharuddin Bin Mohamad
submission deadline 31 Oct 2026 | Viewed by 273 | Submission Open
Keywords: structure–activity relationship (SAR); structure-based drug design; protein structure prediction; molecular docking; molecular dynamics simulation; binding free energy calculations; protein engineering; artificial intelligence in drug discovery; structure–function analysis; computational drug design
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Role of Factors in Embryo Implantation and Placental Development (2nd Edition)
edited by Valentina Lacconi
submission deadline 31 Oct 2026 | Viewed by 271 | Submission Open
Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization
(This special issue belongs to the Section Molecular and Translational Medicine)
Computational and Translational Advances in Precision Oncology submission deadline 31 Oct 2026 | Viewed by 246 | Submission Open
Keywords: precision oncology; molecular targets; artificial intelligence in oncology; multi-omics integration; translational therapeutics; computational oncology; targeted drug delivery; biomarker discovery; systems oncology; digital pathology; clinical translation; single-cell sequencing; liquid biopsy; cancer immunotherapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Transplantation Immunology: Mechanism, Challenges, and Innovations
edited by Hui-Yun Cheng
submission deadline 31 Oct 2026 | Viewed by 223 | Submission Open
Keywords: transplantation immunology; allograft rejection; immune tolerance; macrophage heterogeneity; ischemia–reperfusion injury; biomarkers of rejection; ex vivo machine perfusion; cell-based immunotherapy; precision immunosuppression
(This special issue belongs to the Section Immunology and Immunotherapy)
Adipose Tissue Heterogeneity: Bridging Metabolic Health and Clinical Complications
edited by
submission deadline 31 Oct 2026 | Viewed by 208 | Submission Open
Keywords: adipose tissue; white adipose tissue; brown adipose tissue; beige adipose tissue; thermogenesis; adipokines; adipose tissue inflammation; metabolism; cardiometabolic disease; neuroendocrine regulation
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Bioengineering Research in Cardiovascular Diseases
edited by Thembaninkosi Gaule and Aleksandar Jovanovic
submission deadline 31 Oct 2026 | Viewed by 194 | Submission Open
Keywords: cardiovascular bioengineering; drug delivery systems; biomaterial; engineered proteins; de novo proteins; protein therapeutic, tissues engineering; non-animal models; organ-on-chip; microfluidics; targeted therapeutics; controlled release; nanomedicine, regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Small Molecule Inhibitors for Cancer Therapy submission deadline 31 Oct 2026 | Viewed by 181 | Submission Open
Keywords: small-molecule inhibitors; cancer therapy; drug resistance; medicinal chemistry; precision oncology; targeted protein degradation
(This special issue belongs to the Section Cancer Biology and Oncology)
Biomarkers in Pain: 2nd Edition submission deadline 15 Nov 2026 | 10 articles | Viewed by 12442 | Submission Open
Keywords: analgesia; biomarker; CSF; cytokine; inflammation; neuropathy; neurotransmitter; pain; QoL; sensitization; sensory
(This special issue belongs to the Section Molecular and Translational Medicine)
Eicosanoids and Fatty Acids in Health, Diseases and Therapeutics
edited by Mihai Nechifor
submission deadline 15 Nov 2026 | Viewed by 402 | Submission Open
Keywords: eicosanoids; prostaglandins; leukotrienes; prostacyclin; lipoxins; resolvins; protectins; maresins; arachidonic acid (AA); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); cell functions; immunity; cardiovascular; neuropsychiatric; metabolic; digestive; reproductive; hematologic; inflammatory and oncologic pathology; therapeutics
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research—2nd Edition
edited by
submission deadline 20 Nov 2026 | 6 articles | Viewed by 7285 | Submission Open
Keywords: acute coronary syndrome; cardiovascular morbidity; myocardial infarction; pathophysiology; diagnostic modalities; therapeutic interventions; translational research
(This special issue belongs to the Section Molecular and Translational Medicine)
Metabolic Dysfunction-Associated Steatotic Disease
edited by Junzhao Ye
submission deadline 25 Nov 2026 | 1 articles | Viewed by 1937 | Submission Open
Keywords: metabolic dysfunction-associated fatty liver disease; metabolic dysfunction-associated steatotic disease; novel classification using proteomic and metabolomic profiles; new kinds of lifestyle modification interventions, especially for nutrition interventions; radiologic advances in steatosis, inflammation, and fibrosis assessments; artificial intelligence applications; therapeutic innovations; microbiota
(This special issue belongs to the Section Endocrinology and Metabolism Research)
The Role of Cytokines in Health and Disease: 4th Edition
edited by
submission deadline 29 Nov 2026 | 1 articles | Viewed by 3453 | Submission Open
Keywords: cytokine; chemokine; neurodegenerative disease; cancer; inflammatory mediator; diagnosis; biomarker
(This special issue belongs to the Section Cell Biology and Pathology)
Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome
edited by Hermann L. Müller
submission deadline 30 Nov 2026 | 8 articles | Viewed by 16938 | Submission Open
Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae
(This special issue belongs to the Section Cancer Biology and Oncology)
Advanced Research on Genitourinary Cancer
edited by Jue Wang
submission deadline 30 Nov 2026 | 4 articles | Viewed by 14911 | Submission Open
Keywords: genitourinary (GU) cancer; prostate, bladder, kidney, and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular and Translational Medicine)
Recent Advances in Oral Medicine—2nd Edition submission deadline 30 Nov 2026 | 4 articles | Viewed by 10145 | Submission Open
Keywords: oral medicine; oral manifestations of systemic conditions; drug-induced lesions; oral pathologies; head and neck cancer; autoimmune; oral lesions; bisphosphonates; systemic pharmacotherapy; infectious diseases
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Liver Diseases and Cirrhosis Research submission deadline 30 Nov 2026 | 5 articles | Viewed by 9217 | Submission Open
Keywords: pathogenesis of liver fibrosis and cirrhosis; MASLD; hepatitis B, C and D; primary biliary cholangitis (PBC): immunopathology and treatment advances; alcohol-associated liver disease; liver regeneration and stem-cell-based therapies; biomarkers for early diagnosis and prognosis; emerging antifibrotic treatments; liver complications and systemic comorbidities; personalized medicine in liver disease
(This special issue belongs to the Section Molecular and Translational Medicine)
Applications of Biomedical Engineering and Biomaterials in Human Diseases
edited by Rui Sang
submission deadline 30 Nov 2026 | 7 articles | Viewed by 8396 | Submission Open
Keywords: biosensors and diagnostics; biomedical engineering; nanotechnology in medicine; artificial intelligence in healthcare; precision medicine; drug delivery systems; regenerative medicine; 3D bioprinting; CRISPR-based technologies
(This special issue belongs to the Section Biomedical Engineering and Materials)
Emerging Insights in Thoracic Diseases: From Diagnostics to Biomarkers and Therapeutic Implications Through Interdisciplinarity submission deadline 30 Nov 2026 | 5 articles | Viewed by 7812 | Submission Open
Keywords: chronic obstructive pulmonary disease; acute respiratory diseases; cardionephrology; interstitial lung disease; interventional cardiology; pulmonary fibrosis; tuberculosis; research methodology; biomarkers; therapeutics; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 6849 | Submission Open
Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; mutations; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in Immunotherapy and Radiation Therapy for Cancer (2nd Edition)
edited by and Benjamin Spieler
submission deadline 30 Nov 2026 | 3 articles | Viewed by 6841 | Submission Open
Keywords: radiotherapy; immunotherapy; outcome; toxicity; normal tissue; abscopal; tumor; systemic; local; response
(This special issue belongs to the Section Cancer Biology and Oncology)
Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches
edited by , and Paolo Convertini
submission deadline 30 Nov 2026 | 3 articles | Viewed by 5578 | Submission Open
Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies
(This special issue belongs to the Section Immunology and Immunotherapy)
Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases submission deadline 30 Nov 2026 | 6 articles | Viewed by 5488 | Submission Open
Keywords: periodontal diseases; peri-implantitis; oral lichen planus; oral microbial dysbiosis; inflammatory pathways; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
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