Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1227

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Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO, Clayton 3800, Australia
Interests: nanobiotechnology; drug delivery; pharmaceutics; molecular biology; liposomes; drug targeting; cancer; pharmaceutical nanotechnology
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Special Issue Information

Dear Colleagues,

The field of three-dimensional bioprinting has evolved impressively in the past few years. In fact, this field is considered the latest technology that creates breakthrough innovations and addresses complex medical problems. During this time, 3D bioprinting has successfully served as a potent technology for the processing of biomaterials and living materials into advanced biosystems for in vitro and in vivo applications. Researchers have never had more materials at their disposal, with significant advances in polymers, metals, ceramics, and composites. Three-dimensional bioprinting allows us to construct these materials in any desired shape and size and with increasingly high resolutions as fabrication processes are improved. Trends in the development of this technology indicate that within the next few years, 3D bioprinting will become an important component of patient-specific medical technologies. In this Special Issue, we will highlight the most recent advances in the 3D bioprinting and advanced fabrication of biomaterials for medical and biological applications. Topics will include, but are not limited to, the following:

  • Development and optimization of 3D bioprinting techniques;
  • Latest improvements in functional biomaterials for 3D bioprinting processes;
  • Novel fabrication techniques based on mechanical, acoustic, light, magnetic, electrical and other driving mechanisms;
  • Bio-inks and hydrogels for the engineering of 3D cellular microenvironment;
  • Biomaterial inks for the fabrication of bio-functional scaffolds and substrates;
  • Novel 3D/4D bioprinting techniques and technologies for the fabrication of high-quality bio-based products;
  • Three-dimensional bioprinting and fabrication for tissue engineering, disease modeling, drug delivery, drug testing and other biological applications.

Prof. Dr. M. R. Mozafari
Guest Editor

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Keywords

  • 3D/4D bioprinting techniques
  • 3D bioprinting processes
  • 3D cellular microenvironment
  • bio-inks
  • hydrogels

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Published Papers (1 paper)

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58 pages, 11081 KiB  
Review
3D Printing of Hydrogel Polysaccharides for Biomedical Applications: A Review
by Mohammad Aghajani, Hamid Reza Garshasbi, Seyed Morteza Naghib and M. R. Mozafari
Biomedicines 2025, 13(3), 731; https://doi.org/10.3390/biomedicines13030731 - 17 Mar 2025
Viewed by 844
Abstract
Additive manufacturing, also known as 3D printing, is becoming more and more popular because of its wide range of materials and flexibility in design. Layer by layer, 3D complex structures can be generated by the revolutionary computer-aided process known as 3D bioprinting. It [...] Read more.
Additive manufacturing, also known as 3D printing, is becoming more and more popular because of its wide range of materials and flexibility in design. Layer by layer, 3D complex structures can be generated by the revolutionary computer-aided process known as 3D bioprinting. It is particularly crucial for youngsters and elderly patients and is a useful tool for tailored pharmaceutical therapy. A lot of research has been carried out recently on the use of polysaccharides as matrices for tissue engineering and medication delivery. Still, there is a great need to create affordable, sustainable bioink materials with high-quality mechanical, viscoelastic, and thermal properties as well as biocompatibility and biodegradability. The primary biological substances (biopolymers) chosen for the bioink formulation are proteins and polysaccharides, among the several resources utilized for the creation of such structures. These naturally occurring biomaterials give macromolecular structure and mechanical qualities (biomimicry), are generally compatible with tissues and cells (biocompatibility), and are harmonious with biological digesting processes (biodegradability). However, the primary difficulty with the cell-laden printing technique (bioprinting) is the rheological characteristics of these natural-based bioinks. Polysaccharides are widely used because they are abundant and reasonably priced natural polymers. Additionally, they serve as excipients in formulations for pharmaceuticals, nutraceuticals, and cosmetics. The remarkable benefits of biological polysaccharides—biocompatibility, biodegradability, safety, non-immunogenicity, and absence of secondary pollution—make them ideal 3D printing substrates. The purpose of this publication is to examine recent developments and challenges related to the 3D printing of stimuli-responsive polysaccharides for site-specific medication administration and tissue engineering. Full article
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