Role of Glycomics in Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 172
Special Issue Editor
Interests: glycomics; protein chemistry; tumor immunology; biomarker research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human body and its physiology are characterized by a variety of complex processes and structures. One of these structures is glycans; these are complex carbohydrate molecules that are one of the four primary components of the cell (alongside DNA, proteins, and lipids).
The main functions of glycans are as follows: 1) structural and modulatory roles; 2) extrinsic (interspecies) recognition; 3) intrinsic (intraspecies) recognition; and 4) molecular mimicry of host glycans. Via these functions, carbohydrate structures play a fundamental role in almost every process in our body, e.g., the maintenance of tissue structure, protein trafficking, and ligand binding.
The field of glycome research is gaining more and more attention. The accumulation of aberrant glycan patterns has been demonstrated in various pathological conditions, such as liver diseases, immune-related disorders, nephropathy, and cancer development. Insights into how these changes occur in the glycan machinery remain scarce and further research on the matter is needed.
In this Special Issue, we aim to cover the most recent advances regarding glycomic research in both healthy and diseased states. The main focus will be on, but not limited to, the physiological role of the glycome in the human body, the pathophysiological processes of aberrant glycosylation in disease, the methodological approaches to assess glycan-related biomarkers, and the use of glycan patterns as potential biomarkers for disease diagnosis and risk stratification.
In this Special Issue, we welcome all types of papers (reviews, original papers, or perspective papers) on the aforementioned subject.
Dr. Tijl Vermassen
Guest Editor
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Keywords
- glycomics
- protein chemistry
- tumor immunology
- biomarker research
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