Feature Reviews in Biomaterials for Oral Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1164

Special Issue Editor


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Guest Editor
Department of Prosthetic Dentistry and Materials Science, University Medicine Rostock, Rostock, Germany
Interests: dentistry; oral-health-related quality of life; temporomandibular disorders; temporomandibular joint; psychometric properties in questionnaires; polymers in prosthetic dentistry; tooth wear
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Special Issue Information

Dear Colleagues,

This Special Issue, "Feature Reviews in Biomaterials for Oral Diseases", will focus on feature reviews of current or emerging materials for permanent or long-term intraoral use. This includes bone graft substitutes as well as materials for dental implants, adhesive restorations, or prostheses. In particular, metal-free materials have huge potential for improvement in terms of biocompatibility, fracture resistance, wear, acid solubility, biofilm attachment, and many other properties. This Special Issue focuses on articles that combine known and new knowledge on biomaterials with oral applications to present the current state of the science and identify the need for further research. We cordially invite authors in the field to submit review articles about this important and fast-progressing field of biomedicine.

Prof. Dr. Oliver Schierz
Guest Editor

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Keywords

  • dental composites
  • ceramics
  • zirconia
  • polymers
  • polyaryletherketone
  • polyoxymethylene
  • titanium
  • bone graft materials
  • implants

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Published Papers (1 paper)

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Research

11 pages, 868 KiB  
Article
Residual TPO Content of Photopolymerized Additively Manufactured Dental Occlusal Splint Materials
by Philipp Messer-Hannemann, Max Wienhold, Hoda Esbak, Alexander Brunner, Andreas Schönebaum, Falk Schwendicke and Susanne Effenberger
Biomedicines 2025, 13(1), 44; https://doi.org/10.3390/biomedicines13010044 - 27 Dec 2024
Cited by 1 | Viewed by 734
Abstract
Background/Objectives: Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) is widely used in the dental industry as a photoinitiator for resin-based materials, while its use may be further limited given its toxicological risks. The aim of this study was, therefore, to analyze the residual TPO [...] Read more.
Background/Objectives: Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) is widely used in the dental industry as a photoinitiator for resin-based materials, while its use may be further limited given its toxicological risks. The aim of this study was, therefore, to analyze the residual TPO content of 3D-printed resin-based dental splint materials. Methods: Six resin-based splint materials were analyzed: LuxaPrint Ortho Plus (DMG), FREEPRINT splint 2.0 (Detax), optiprint splint (Dentona), KeySplint Soft (KeyPrint), FREEPRINT ortho (Detax), V-Print splint comfort (Voco). Grid-shaped specimens were fabricated using the recommended workflow of each manufacturer (n = 18). TPO extraction was conducted using a maximum of eight extraction cycles of 72 h at a temperature of 37 °C until no more TPO eluates were detected by high-performance liquid chromatography (HPLC). The margin of safety (MoS) was calculated as the ratio between the Derived No-Effect Level (DNEL) and the estimated exposure based on the amount of TPO extracted. Results: The total amount of extracted TPO was the lowest for LuxaPrint Ortho Plus (Mean ± SD; 44.0 ± 17.1 ng/mL), followed by optiprint splint (80.6 ± 21.1 ng/mL), FREEPRINT splint 2.0 (127.4 ± 25.3 ng/mL), FREEPRINT ortho (2813.2 ± 348.0 ng/mL), V-Print splint comfort (33,424.6 ± 8357.9 ng/mL) and KeySplint Soft (42,083.5 ± 3175.2 ng/mL). For all tested materials, the calculated MoS was above the critical value of 1, demonstrating toxicological safety in the cured, clinically relevant state. Conclusions: Large differences in the residual TPO content were observed between the materials. Although the TPO content in the uncured state may exceed toxicological safety limits, appropriate curing of the investigated materials resulted in a significant reduction in TPO elution and, thus, in products with a very low toxicological risk for the patient. Full article
(This article belongs to the Special Issue Feature Reviews in Biomaterials for Oral Diseases)
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