Intestinal Homeostasis and Disease Dysbiosis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editor
Interests: microbiome; metagenomics; bioinformatics; drug repositioning
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Intestinal homeostasis represents the dynamic equilibrium between the gut microbiota, the intestinal epithelial barrier, the immune system, and host-derived factors, all of which collectively sustain gastrointestinal health and function. This Special Issue delves into the latest scientific advances that elucidate how this balance is maintained and the mechanisms through which it is disrupted, leading to disease. The gut microbiota functions as a crucial metabolic organ, influencing nutrient assimilation, immune maturation, and defense against pathogens. However, this intricate system is highly sensitive to external and internal perturbations, including dietary changes, antibiotic exposure, psychological stress, and genetic predisposition, all of which can reshape the microbial ecosystem.
The disruption of this equilibrium, a condition termed dysbiosis, often results in the expansion of potentially harmful microbial populations that impair host metabolism, compromise immune regulation, and the weaken epithelial barrier’s integrity. Such alterations have been implicated in a wide array of diseases. The cutting-edge studies featured in this Special Issue investigate the ecological origins of dysbiosis, its clinical correlates, and promising therapeutic interventions.
Furthermore, this collection highlights the growing importance of microbiota–drug interactions, examining how gut microbes influence drug metabolism, efficacy, and toxicity. These interactions are bidirectional: while medications can significantly alter microbial composition and function, microbial enzymes can activate, inactivate, or transform xenobiotics, with implications for pharmacokinetics and therapeutic outcomes. By dissecting the molecular, metabolic, and immunological frameworks that distinguish a healthy (eubiotic) from a dysbiotic state, the contributions in this Special Issue pave the way for innovative strategies in diagnosis, personalized therapy, and disease prevention.
Dr. Nikolas Dovrolis
Guest Editor
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Keywords
- gut microbiota
- intestinal homeostasis
- dysbiosis
- microbiota–drug interactions
- host–microbe interactions
- microbiome therapeutics
- precision medicine
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