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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Therapeutic Strategies of Metabolic Dysfunction-Associated Diseases

edited by

Vasile Negrean

and

Mircea Vasile Milaciu

submission deadline 20 May 2025 | Viewed by 397 | Submission Open

Keywords: metabolic dysfunction; metabolic syndrome; therapeutic strategies; obesity; diabetes; cardiovascular diseases; non-alcoholic fatty liver disease; genetic regulation; cellular metabolism; pharmacological interventions

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Supraventricular and Ventricular Cardiac Arrhythmias Systemic Implications: From Mechanisms to Clinical Treatment

edited by

Alina Negru

and

Gabriel Cismaru

submission deadline 20 May 2025 | Viewed by 176 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; ventricular tachycardia; AVNRT; PVC; supraventricular tachycardia; catheter ablation; electrophysiological study; heart failure; arrhythmias diagnostic; antiarrhythmic treatment; biomarkers; ion channels; cardiac resynchronization therapy; ICD

(This special issue belongs to the Section Molecular and Translational Medicine)

Thyroid Disease: From Mechanism to Therapeutic Approaches

edited by

Beata Wojtczak

submission deadline 31 May 2025 | 9 articles | Viewed by 22478 | Submission Open

Keywords: pathogenesis and molecular mechanism of thyroid diseases; genetic disorders of the thyroid biomarkers for thyroid dysfunctions; diagnostic challenges; new thyroid’ s therapies; immunotherapy; nuclear medicine; minimal invasive treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Vesicles and Exosomes as Therapeutic Agents

edited by

David J. Rademacher

submission deadline 31 May 2025 | 9 articles | Viewed by 22451 | Submission Open

Keywords: extracellular vesicles; exosomes; therapeutics; drug delivery; bioengineering

(This special issue belongs to the Section Cell Biology and Pathology)

Urothelial Carcinoma: Role of Biomarkers in Diagnosis, Prognosis and Treatment

edited by Ioannis Zachos and

Panagiotis Vlachostergios

submission deadline 31 May 2025 | 8 articles | Viewed by 17163 | Submission Open

Keywords: urothelial carcinoma; biomarker; diagnosis; treatment; prognosis

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into Breast Cancer Management: From Tumorigenesis to Personalized Treatments

edited by

Paola Tiberio

and

Rita De Sanctis

submission deadline 31 May 2025 | 9 articles | Viewed by 16241 | Submission Open

Keywords: breast cancer; diagnosis; prognosis; treatment response prediction; biomarkers; risk factors; new therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Drug Resistance and Novel Targets for Cancer Therapy—Second Edition

edited by

Bruno Kaufmann Robbs

and

Fernando de Carvalho da Silva

submission deadline 31 May 2025 | 7 articles | Viewed by 14057 | Submission Open

Keywords: cancer; drug resistance; targeted therapy; conventional chemotherapy; natural products; molecular targets; cancer hallmarks; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Pathogenesis, Diagnostics and Therapeutics in Obsterics and Gynaecology

edited by

Nikolaos Machairiotis

submission deadline 31 May 2025 | 12 articles | Viewed by 13005 | Submission Open

Keywords: gynaecology; obstetrics; diagnosis; pathogenesis; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Applications of Imaging Technology in Human Diseases

edited by

Giulio Distefano

and

Antonio Granata

submission deadline 31 May 2025 | 10 articles | Viewed by 11213 | Submission Open

Keywords: medical imaging; advanced radiological techniques; artificial intelligence; molecular imaging; computed tomography (CT); magnetic resonance imaging (MRI); ultrasound; fluoroscopy; optical imaging; liquid biopsy

(This special issue belongs to the Section Biomedical Engineering and Materials)

Glaucoma: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Da-Wen Lu

submission deadline 31 May 2025 | 9 articles | Viewed by 10919 | Submission Open

Keywords: glaucoma; ocular pharmacology; ocular disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Human Stem Cells in Disease Modelling and Treatment

edited by Sofia M. Calado and

Álvaro Plaza Reyes

submission deadline 31 May 2025 | 5 articles | Viewed by 10087 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Current Perspectives on Human Papillomavirus (HPV)

edited by

Vanja Kaliterna

and

Tomislav Meštrović

submission deadline 31 May 2025 | 4 articles | Viewed by 10050 | Submission Open

Keywords: Human Papillomavirus (HPV); molecular mechanisms; diagnosis; treatment; prevention; vaccination; screening; immunotherapy; cancer

(This special issue belongs to the Section Microbiology in Human Health and Disease)

New Challenges in the Study of Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches—the 3rd Edition

edited by

Marica Meroni

submission deadline 31 May 2025 | 5 articles | Viewed by 10035 | Submission Open

Keywords: liver diseases and related pathologies; nonalcoholic fatty liver disease (NAFLD); obesity; type 2 diabetes; cardiovascular diseases; gut– liver axis; viral hepatitis; alcoholic liver disease (ALD); cholestatic disorders; personalized medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomarkers in Metabolic Disorders, Obesity and Type 2 Diabetes Mellitus

edited by

Maciej Walędziak

and Anna Maria Różańska-Walędziak

submission deadline 31 May 2025 | 6 articles | Viewed by 8791 | Submission Open

Keywords: metabolic disorders; obesity; type 2 diabetes mellitus; bariatric surgery; laboratory parameters

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Diabetes Complications: From Pathophysiology to Novel Therapeutic Approaches 2.0

edited by

Usama Elewa

submission deadline 31 May 2025 | 3 articles | Viewed by 7271 | Submission Open

Keywords: diabetes complications; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration

(This special issue belongs to the Section Molecular and Translational Medicine)

Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches

edited by Raimunda Nonata Ribeiro Sampaio

submission deadline 31 May 2025 | 3 articles | Viewed by 7131 | Submission Open

Keywords: leishmaniasis; pathophysiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches

edited by

Rui Adão

submission deadline 31 May 2025 | 3 articles | Viewed by 5707 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomarkers in Neurological Disorders

edited by

Mamiko Koshiba

submission deadline 31 May 2025 | 2 articles | Viewed by 5579 | Submission Open

Keywords: human application; EEG; biomarker

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advanced Research in Neuroprotection

edited by Evangelia Kesidou, Iliana Michailidou and

Christos Bakirtzis

submission deadline 31 May 2025 | 3 articles | Viewed by 5533 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)

edited by

Fumihiko Namba

submission deadline 31 May 2025 | 4 articles | Viewed by 5511 | Submission Open

Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches

(This special issue belongs to the Section Cell Biology and Pathology)

Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches

edited by

David J. Rademacher

submission deadline 31 May 2025 | 2 articles | Viewed by 5138 | Submission Open

Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics

(This special issue belongs to the Section Cell Biology and Pathology)

Extracellular Matrix in Health and Disorders

edited by

Caterina Licini

submission deadline 31 May 2025 | 2 articles | Viewed by 4716 | Submission Open

Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon

(This special issue belongs to the Section Molecular and Translational Medicine)

Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches

edited by

Lu Li

submission deadline 31 May 2025 | 3 articles | Viewed by 4570 | Submission Open

Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions

(This special issue belongs to the Section Molecular and Translational Medicine)

Genomic Insights and Translational Opportunities for Human Cancers

edited by

Apostolos Zaravinos

and

Ilias Georgakopoulos-Soares

submission deadline 31 May 2025 | 2 articles | Viewed by 4483 | Submission Open

Keywords: genomics; cancer genomics; biomarkers; machine learning; bioinformatics; liquid biopsies; cell-free DNA; cell-free RNA

(This special issue belongs to the Section Cancer Biology and Oncology)

Killing It Softly–New Approaches to Overcome Cancer Chemoresistance 2.0

edited by

Beata Pajak-Tarnacka

and

Anna Jaśkiewicz

submission deadline 31 May 2025 | 2 articles | Viewed by 4281 | Submission Open

Keywords: cancer; chemoresistance; anticancer drug; sensitization to chemotherapy; molecular mechanisms of chemoresistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies

edited by

Foteini Christidi

and

Dimitrios Tsiptsios

submission deadline 31 May 2025 | 4 articles | Viewed by 4186 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Histone Deacetylase and Its Inhibitors: Drug Discovery, Molecular Mechanism, and Clinical Implications

edited by

Saccoccia Fulvio

submission deadline 31 May 2025 | 2 articles | Viewed by 4141 | Submission Open

Keywords: HDACs inhibitors; molecular mechanism; molecular dynamics; virtual screening

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Molecular and Clinical Aspects of Endometriosis Pathophysiology

edited by

Quanah J. Hudson

and

Iveta Yotova

submission deadline 31 May 2025 | 3 articles | Viewed by 4021 | Submission Open

Keywords: endometriosis; pathophysiology; estrogen; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Cell Biology and Pathology)

Extracellular Vesicles for Diagnosis and Treatment of Human Diseases

edited by

Zoran Minic

submission deadline 31 May 2025 | 3 articles | Viewed by 4018 | Submission Open

Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuroinflammation and Neuroprotection

edited by

Brandon Lucke-Wold

submission deadline 31 May 2025 | 2 articles | Viewed by 3882 | Submission Open

Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition

edited by

Xiufang Guo

submission deadline 31 May 2025 | 2 articles | Viewed by 3804 | Submission Open

Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Gastrointestinal Diseases

edited by

Fu-Chen Huang

submission deadline 31 May 2025 | 3 articles | Viewed by 3718 | Submission Open

Keywords: precision medicine; artificial intelligence; eosinophilic gastrointestinal diseases; inflammatory bowel disease; irritable bowel syndrome; gastroesophageal reflux disease; gastrointestinal cancers; drug-resistant infections

(This special issue belongs to the Section Molecular and Translational Medicine)

Antibody–Drug Conjugates and Cancer Immunotherapy

edited by Sofia Genta

submission deadline 31 May 2025 | 1 articles | Viewed by 3270 | Submission Open

Keywords: ADC; immunotherapy; cancer; drug resistance; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Novel Insights into Liver Metabolism

edited by

Agata Michalak

and

Halina Cichoż-Lach

submission deadline 31 May 2025 | 2 articles | Viewed by 3132 | Submission Open

Keywords: liver; metabolism; oxidative stress; mi-RNAs; cirrhosis; alcohol-related liver disease; autoimmune liver disorders; hepatocellular cancer; liver steatosis; microbiota; diagnostic markers

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Insights in Gastric, Colorectal, and Pancreatic Cancer

edited by

John K. Triantafillidis

submission deadline 31 May 2025 | 2 articles | Viewed by 2984 | Submission Open

Keywords: gastric cancer ; colorectal cancer ; pancreatic cancer; immunotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Upper Respiratory Infection: From Pathology to Novel Therapeutic Approaches

edited by Puya Dehgani-Mobaraki

submission deadline 31 May 2025 | 2 articles | Viewed by 2921 | Submission Open

Keywords: upper respiratory infections (URIs); rhinology; biological therapies; nasal polyposis; chronic rhinosinusitis; allergic rhinitis; endoscopic sinus surgery; monoclonal antibodies; pharmacological innovations

(This special issue belongs to the Section Molecular and Translational Medicine)

Iron Metabolism Rewiring and Ferroptosis to Trigger Drug Resistance in Human Cancers

edited by Anna Martina Battaglia

submission deadline 31 May 2025 | 1 articles | Viewed by 2548 | Submission Open

Keywords: ferroptosis; iron metabolism; reactive oxygen species; resistance mechanisms; iron compound; ferroptosis inducer

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Endometriosis and Adenomyosis

edited by

Xinmei Zhang

and

Chi Chiu Wang

submission deadline 31 May 2025 | 1 articles | Viewed by 2392 | Submission Open

Keywords: endometriosis; adenomyosis; pathogenesis; diagnosis and treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in the Role of Regulatory T Cells in Immunity

edited by Mehdi Benamar

submission deadline 31 May 2025 | 1 articles | Viewed by 2248 | Submission Open

Keywords: regulatory T cells; immune regulation; autoimmune diseases; tolerance; Foxp3; immunomodulatory therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Lipogenesis and Lipolysis: Insights from Molecular Perspectives

edited by

Miran Jang

submission deadline 31 May 2025 | 1 articles | Viewed by 2078 | Submission Open

Keywords: lipogenesis; lipolysis; fat metabolism

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Bench-to-Bedside Approach to Migraine: How Pathophysiology Could Influence Novel Therapeutic Approaches and Back

edited by Alessandro Vigano and Matteo Castaldo

submission deadline 31 May 2025 | 2 articles | Viewed by 1776 | Submission Open

Keywords: migraine; comorbidities; pathophysiology; pharmacological interventions; non-pharmacological interventions; chronicization; neurophysiological or neuroimaging for disability or clinical response

(This special issue belongs to the Section Molecular and Translational Medicine)

Hypertension and Chronic Renal Failure

edited by

Caterina Carollo

submission deadline 31 May 2025 | 2 articles | Viewed by 1677 | Submission Open

Keywords: hypertension; chronic renal failure; NephroCardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease: Third Edition

edited by

Natalia N. Ninkina

submission deadline 31 May 2025 | 1 articles | Viewed by 1473 | Submission Open

Keywords: synuclein family; alpha-synuclein; beta-synuclein; gamma-synuclein; physiological functions of synucleins; synucleins and lipids; function of synucleins outside of the nervous system; synuclein-associated pathology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Medicinal Chemistry in Drug Design and Discovery, 2nd Edition

edited by

Małgorzata Jarończyk

submission deadline 31 May 2025 | 1 articles | Viewed by 1407 | Submission Open

Keywords: design and synthesis of medicinal compounds; identification and characteristics of targets; mechanism of action; profiles of safety; structure– activity relationship; ligand– target interactions; drugs repurposing

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Progress in Nanotechnology-Based Therapeutic Strategies

edited by Ambra Del Grosso and Mariacristina Gagliardi

submission deadline 31 May 2025 | 2 articles | Viewed by 1395 | Submission Open

Keywords: nanotechnology-based therapies; targeted drug delivery; nanoparticles; nanostructures; cancer treatment; cardiovascular diseases; neurodegenerative diseases; infectious diseases; lysosomal storage disorders; regenerative medicine; tissue engineering; gene therapy; biochemical diagnostics; omics approaches; biological barriers

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Cutting-Edge Research in Exosomes and Extracellular Vesicles

edited by Sushma Anand

submission deadline 31 May 2025 | 1 articles | Viewed by 1210 | Submission Open

Keywords: drug delivery; targeted therapy; EV engineering; cargo loading; molecular profiling; retinal degeneration; neurodegenerative disease; therapeutic application

(This special issue belongs to the Section Cell Biology and Pathology)

Retinal Diseases: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Irini P. Chatziralli

and Konstantinos Pappelis

submission deadline 31 May 2025 | 4 articles | Viewed by 1135 | Submission Open

Keywords: age-related macular degeneration; central serous chorioretinopathy; pachychoroid spectrum; choroidal neovascularization; diabetic retinopathy; retinal vein occlusion; retinal artery occlusion; sickle cell retinopathy; optical coherence tomography; OCT angiography; widefield imaging; anti-VEGF agents

(This special issue belongs to the Section Molecular and Translational Medicine)

Infectious Diseases: Prevention, Diagnosis, and Treatment Under Antimicrobial Resistance Global Urgency

edited by

Célia F. Rodrigues

submission deadline 31 May 2025 | 1 articles | Viewed by 1101 | Submission Open

Keywords: AMR; infectious diseases; bacteria; fungi; alternative treatment

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)

edited by

Gvantsa Kharaishvili

submission deadline 31 May 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: prostate cancer; castration-resistant prostate cancer; metastatic disease; biomarker; tumor microenvironment; treatment; immunotherapy; drug resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Developments in Microangiopathic Hemolytic Anemia Disease Presentations

edited by

Robert Maitta

submission deadline 31 May 2025 | 1 articles | Viewed by 970 | Submission Open

Keywords: thrombotic thrombocytopenic purpura; thrombocytopenia; ADAMTS13; rituximab; immunosuppression; therapeutic plasma exchange; von Willebrand factor

(This special issue belongs to the Section Molecular and Translational Medicine)

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