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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Pathogenesis to Therapies: Innovations in Kidney Disease

edited by

Tao Qiu

Jiefu Zhu

and Chenglin Wu

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: renal ischemia-reperfusion injury; acute kidney injury; renal fibrosis; chronic kidney disease; ureteral obstructive nephropathy; kidney transplantation; macrophage-myofibroblast transition; inflammation; fibroblast activation; chronic allograft rejection; potential therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Modern Applications of Advanced Imaging to Neurological Disease

edited by Manisha Koneru and

Hamza Adel Salim

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: neuroimaging; cerebrovascular disease; neuro-oncology; compted tomography; magnetic resonance imaging; patient outcomes; neurosciences; neuroradiology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies

edited by

Denggang Fu

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: tumor microenvironment (TME); immune evasion; tumor– immune interaction; stromal remodeling; cancer immunotherapy; metabolic reprogramming; epigenetic regulation; multi-omics and spatial analysis; anticancer drug development

(This special issue belongs to the Section Immunology and Immunotherapy)

Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

Autophagy-Mediated Signalling in Cancer Metastasis and Progression

edited by

Ahmed M. Elshazly

and

David A. Gewirtz

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: autophagy; cancer; resistance; metastasis; tumor microenvironment; immune evasion

(This special issue belongs to the Section Cancer Biology and Oncology)

State-of-the-Art Drug Discovery and Development in Poland (3rd Edition)

edited by

Aleksandra Romaniuk-Drapała

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: in silico drug target profiling; drug delivery systems; drug– drug interaction; target-based screening; phenotypic screening; pharmaceutical modeling; computational chemistry; targeted therapy; biomarkers; bioimaging

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Immunological Barriers and Novel Therapeutic Strategies in Pediatric Brain Tumor Immunotherapy

edited by Dalia Haydar

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: pediatric brain tumors; diffuse intrinsic pontine glioma (DIPG); medulloblastoma; chimeric antigen receptor (CAR) T cells; blood– brain barrier (BBB); tumor microenvironment (TME); immune resistance; adoptive cell therapy; biomarkers; combination immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Research on Neuroendocrine Neoplasms and Endocrine Sequelae After Oncological Disease

edited by Hermann L. Müller

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: neuroendocrine tumors; endocrinology; hormones; cancer; sequelae; late effects; neurogenic tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Diagnosis, Pathogenesis, Treatment and Prognosis of Glioblastoma, 2nd Edition

edited by

Paulo Linhares

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: glioblastoma; immunotherapy; molecular subtype; radiotherapy; molecular therapy; emerging treatment; drug resistance; MRI; immune surveillance

(This special issue belongs to the Section Cancer Biology and Oncology)

Diabetic Nephropathy and Diabetic Atherosclerosis (2nd Edition)

edited by

Satyesh K. Sinha

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: diabetic nephropathy; diabetic atherosclerosis; diabetes; inflammation; oxidative stress; renal and vascular cell dysfunction; basic science; clinical practice; patient outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)

edited by

Fernando Cardona

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; mutations; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nanoparticles in Biomedical Engineering: From Drug Delivery to Tissue Engineering

edited by Jia Nong

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: nanoparticle; nanomedicine; nanoconjugates; drug delivery; biomaterials; wound healing; angiogenesis; antimicrobial agents; regenerative medicine; theranostics

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Targeting Mast Cells in Human Disease: Bridging Pathology and Therapy

edited by Marianna Criscuolo

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: mast cell; mast cell activation syndrome; anaphylaxis; mastocytosis; anti-mediator therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Innovative Therapeutic Strategies and Molecular Mechanisms in Breast Cancer

edited by

Oana Gabriela Trifanescu

and

Laurentia Nicoleta Gales

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: breast cancer; immunotherapy; medical imaging; biomarkers; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomaterials and Nanotechnology for Advanced Wound Dressings

edited by Javad Esmaeili

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: wound dressings; wound healing; biomaterials and nanotechnology; regenerative medicine; targeted delivery

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Expanding Opioid Receptor Pharmacology: From Pain Control to Novel Therapeutic Applications in Neurobiology, Immunology, and Psychiatry

edited by

Luca Gentilucci

submission deadline 30 Apr 2026 | Viewed by 25 | Submission Open

Keywords: opioid; pain; mood; stress; addiction; neuropeptides

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Novel Directions for Effective Treatments of Malignant Brain Tumors, Particularly Glioblastoma, Indicated by In Vivo Observations

edited by

Jacek M. Kwiecien

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: glioblastoma; glioblastoma cell invasion; inhibition of glioblastoma cell migration; glioblastoma cell proliferation; killing of glioblastoma cells; white matter inflammation post-neurosurgery; white matter inflammation post-irradiation; cerebral vasogenic edema; treatment of neuroinflammation and vasogenic edema; imaging of glioblastoma

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Roles of Extracellular Vesicles in Health and Diseases

edited by David R. Brigstock and Xinlei Li

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: extracellular vesicle; exosome; pathogenesis; therapy; cancer; neurodegenerative diseases; pulmonary diseases; cardiovascular diseases; inflammatory diseases; infectious diseases; kidney diseases; gastrointestinal diseases; aging; diabetes; autoimmune disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Epilepsy: From Mechanisms to Therapeutic Approaches (2nd Edition)

edited by

Prosper N'Gouemo

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: genetic epilepsy; acquired epilepsy; neonatal seizures; epileptogenesis; pharmacoresistant epilepsy; ion channels; calcium signaling

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Cancer Metastasis Models

edited by

Lin Zhang

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: cancer metastasis; tumor microenvironment; metastasis models; 3D cell culture; organoids; artificial intelligence in oncology; machine learning; bioinformatics; in vivo imaging; multi-omics integration

(This special issue belongs to the Section Cancer Biology and Oncology)

Nanocarriers in Mucosal Drug Delivery

edited by

Hatem Hassan

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: nanocarriers; mucosal drug delivery; mucoadhesion; mucus penetration; controlled release; bioavailability enhancement; targeted delivery; stimuli-responsive systems

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biomarker, Phenotyping and Therapeutics for Asthma

edited by

Ran Wang

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Polyamines in Human Health and Disease—Second Edition

edited by

Kuniyasu Soda

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: polyamine; spermidine; spermine; health; disease; development

(This special issue belongs to the Section Immunology and Immunotherapy)

Alzheimer's Disease: Pathogenesis, Diagnostics and Novel Treatment Options

edited by

Rui Zhong

and Ling Li

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: amyloid and tau pathology; neuroinflammation and oxidative stress; neuromodulation; fluid biomarkers; imaging and other diagnostic approaches; small-molecule therapeutics; novel therapeutics and emerging therapies; disease-modifying therapies; experimental and clinical pharmacology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cancer Genetics: Bench-to-Bedside Advances

edited by

Hengrui Liu

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: cancer genetics; somatic mutations; biomarkers; cfDNA/ctDNA; epigenetics; tumor microenvironment; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Artificial Intelligence in Cancer Imaging: Advancing Precision Oncology

edited by Farhan Akram

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: artificial intelligence; cancer imaging; digital pathology; machine learning; deep learning; radiomics; tumor characterization; precision oncology; biomarker discovery; clinical translation

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Periodontal Disease and Systemic Disease

edited by Hye-Sun Shin

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: periodontal disease; systemic health; inflammation; oral microbiome; cardiovascular disease; diabetes; cancer; oral– gut– brain axis; precision medicine; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuropathology: Understanding Local and Systemic Influence of Disease and Vice-Versa

edited by

Kumar Vaibhav

Pankaj Gaur

, Meenakshi Ahluwalia,

Pankaj Ahluwalia

and Shashi Nandar Kumar

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: brain pathologies; brain injury; Parkinson’ s disease; Alzheimer’ s disease; stroke; neurodegeneration; hemorrhages; hypoxia; neuroinflammation; translational approaches; oxidative stress; COVID-19; gut– brain axis; systemic influence; immune interaction; synaptic plasticity; ageing; senescence; bone marrow and neuropathology; pesticides; preservatives and environmental contamination; lungs and brain; liver and brain; cardiovascular effect of brain pathology and vice-versa; acute and chronic neuro-immune interaction; therapeutic strategies and intervention; alternative medicines in brain pathologies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Muscular Dystrophy: From Mechanisms to Therapeutic Approaches

edited by

Gisela Gaina

and Marco A.F. Fernandes

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: muscular dystrophy; genetic diseases; muscle regeneration; therapeutic approaches; molecular diagnosis; in vitro and in vivo models

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Advances in the Treatment of Brain Tumors

edited by

Harim Koo

submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open

Keywords: neuro-oncology; brain tumor; cancer therapy; precision medicine; biomarkers; drug delivery; multi-omics; neurosurgery; clinical trials; bioinformatics

(This special issue belongs to the Section Cancer Biology and Oncology)

Genetic Research into Human Reproduction

edited by

Efthalia Moustakli

and Athanasios Zikopoulos

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: reproductive genomics; assisted reproductive technologies (ARTs); reproductive endocrinology; embryo development; reproductive bioinformatics; precision fertility medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Photodynamic Therapy in Cancer—Second Edition

edited by

Shazia Bano

submission deadline 30 Apr 2026 | Submission Open

Keywords: photodynamic therapy; targeted drug delivery and drug release systems; photodiagnosis/tumor imaging; PDT-induced immunogenic cell death; nanomaterials-based combination therapies; theranostics

(This special issue belongs to the Section Cancer Biology and Oncology)

Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

edited by Eleni Georgakopoulou and George Laskaris

submission deadline 30 Apr 2026 | Submission Open

Keywords: oral pathologies; oral diseases; pathogenesis; therapeutic interventions; interdisciplinary nature of oral healthcare; xerostomia; dysgeusia; oral cancer; precancerous lesions; oral inflammatory conditions

(This special issue belongs to the Section Cell Biology and Pathology)

Correlative Light and Electron Microscopy (CLEM) in Biomedicine: Advances and Applications

edited by

Hideya Kawasaki

submission deadline 30 Apr 2026 | Submission Open

Keywords: CLEM; correlative microscopy; biomedicine; pathology; virology; oncology; immunolabeling; cryo-microscopy; ultrastructure; image analysis

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research into Adipose‐Derived Stem Cells

edited by

Anna Barbara Di Stefano

and Mara Franza

submission deadline 31 May 2026 | 1 articles | Viewed by 2628 | Submission Open

Keywords: adipose stem cells; regenerative medicine; stemness; differentiative potential; pre-clinical and clinical applications

(This special issue belongs to the Section Molecular and Translational Medicine)

Immunotherapy and Targeted Treatment in Solid Tumors: Biomarkers and Novel Therapeutic Strategies

edited by

Dana Lucia Stănculeanu

and

Adelina Silvana Gheorghe

submission deadline 31 May 2026 | 2 articles | Viewed by 1300 | Submission Open

Keywords: immunotherapy; targeted therapy; biomarkers; tumor microenvironment; molecular profiling; precision oncology; treatment resistance; solid tumors; translational oncology

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Therapeutic Strategies and Precision Medicine in Solid Tumors and Metastasis—2nd Edition

edited by

Silvia Di Agostino

and

Vittoria Rago

submission deadline 31 May 2026 | 1 articles | Viewed by 1211 | Submission Open

Keywords: kinase inhibitor; immunotherapy; chemotherapy; precision molecular therapy; biomarkers; synthetic lethality; theranostics; drug repurposing; radiomics

(This special issue belongs to the Section Cancer Biology and Oncology)

Prostate Cancer Pathology: Recent Advances and Future Perspectives

edited by

Kostis Gyftopoulos

submission deadline 31 May 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: prostate cancer; pathology; digital pathology; Gleason grading; molecular biomarkers; precision medicine; molecular pathology; molecular profiling; therapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances Research on Nanomedicine

edited by

Rongcheng Han

submission deadline 31 May 2026 | 1 articles | Viewed by 1096 | Submission Open

Keywords: multifunctional nanomaterials; nanomedicine; tumor; theranostics; artificial intelligence (AI); immunotherapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

The Human Proteinomics in Disease, Diagnostics and Translation into Precision Medicine: Current Status and Future Prospects—2nd Edition

edited by

M. Walid Qoronfleh

submission deadline 31 May 2026 | 1 articles | Viewed by 829 | Submission Open

Keywords: proteomics; human proteome; systems biology; precision medicine; biomarker(s); disease pathogenesis; diagnostics; mass spectrometry; tandem mass spectrometry; LC-MS/MS; peptides and proteins; multiplex protein analysis; protein network; protein– protein interaction; splice variants; post-translational modifications; omics analysis; data integration; bioinformatics; artificial intelligence; deep learning

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Drug Discovery and Development: From Rational Design to Experimental Validation

edited by

Vikas Kumar

submission deadline 31 May 2026 | Viewed by 308 | Submission Open

Keywords: drug discovery; drug development; rational drug design; molecular docking; virtual screening; pharmacophore modeling; molecular dynamics simulations; machine learning in drug discovery; deep learning in drug discovery; experimental validation; structure– activity relationship; bioactive compounds

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Exploring Conventional and Alternative Animal Models in Biomedical Research (Biomedicines)

edited by

Elisa Panzarini

and

Stefania Mariano

submission deadline 31 May 2026 | Viewed by 203 | Submission Open

Keywords: disease modelling; drug discovery and delivery; toxicology; personalized medicine; bioengineering; computational biology; ethical considerations; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Unveiling the Genetic Architecture of Complex and Common Diseases

edited by

Mahmut Cerkez Ergoren

submission deadline 31 May 2026 | 1 articles | Viewed by 194 | Submission Open

Keywords: polygenetic score; cardiovascular disorders; metabolic disorders; neurodegenerative disorders

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Tumor Biomarkers in Gynecology—2nd Edition

edited by

Corrado Terranova

and

Francesco Plotti

submission deadline 31 May 2026 | Viewed by 166 | Submission Open

Keywords: gynecological cancers; precision medicine; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Immunometabolism in Cancer and Autoimmunity: Mechanisms and Therapeutic Targeting

edited by

Xiancai Zhong

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: immunometabolism; cancer; autoimmunity; metabolic reprogramming; nutrient sensing; organelle dynamics; metabolic interventions

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Circadian Rhythms

edited by

Ivana Škrlec

and Zrinka Biloglav

submission deadline 31 May 2026 | Viewed by 28 | Submission Open

Keywords: circadian rhythms; biological clocks; chronobiology; sleep– wake regulation; clock genes; chronotherapy; temporal physiology; circadian misalignment; molecular chronobiology; circadian biomarkers

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advances in Pain Management: Exploring Molecular Mechanisms and Novel Therapies

edited by

Christopher Robinson

Samuel Ang

and Rodrigo Diez-Tafur

submission deadline 31 May 2026 | Viewed by 2 | Submission Open

Keywords: chronic pain; neuroinflammation; sensory signaling; epigenetics; neuroimmune interactions; regenerative medicine; stem cells

(This special issue belongs to the Section Molecular and Translational Medicine)

Mitochondrial Dysfunction in Health and Disease: Implications for Cellular Metabolism and Therapeutic Approaches

edited by Chellakkan S. Blesson

submission deadline 31 May 2026 | Viewed by 1 | Submission Open

Keywords: mitochondria; metabolic reprogramming; cellular metabolism; ROS; mitochondrial dynamics; mitochondrial dysfunction

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Mechanisms and Therapeutic Approaches for Oral Disorders: 2nd Edition

edited by Simona Santonocito and

Vincenzo Ronsivalle

submission deadline 31 May 2026 | Viewed by 1 | Submission Open

Keywords: oral diseases; drugs; local drug delivery; periodontitis; causal periodontal therapy; oral potential malignant disorders; oral cancer; oral medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Lipid Metabolism and Lipidomics in Human Diseases

edited by

Ilenia Calcaterra

submission deadline 31 May 2026 | Submission Open

Keywords: lipid metabolism; lipidomics; biomarkers; cardiovascular disease; metabolic syndrome; inflammation; PCSK9 inhibitors; personalized medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

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