Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multidisciplinary Approaches to Neurodegenerative Disorders
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 6600 | Submission Open
Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 6394 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); gastro-esophageal reflux disease (GERD); obesity; cardiometabolic comorbidities; type 2 diabetes; hypertension; gut hormones; gastrointestinal function
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Biomarkers in Metabolic Disorders, Obesity and Type 2 Diabetes Mellitus—2nd Edition
edited by and Anna Maria Różańska-Walędziak
submission deadline 31 Oct 2026 | 5 articles | Viewed by 5985 | Submission Open
Keywords: metabolic disorders; obesity; type 2 diabetes mellitus; bariatric surgery; laboratory parameters
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 5839 | Submission Open
Keywords: neurovascular; blood vessels; nervous system; neurological diseases
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Emerging Technologies in Liquid Biopsy of Cancers
edited by Lingdi Yin
submission deadline 31 Oct 2026 | 2 articles | Viewed by 5748 | Submission Open
Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling
(This special issue belongs to the Section Cancer Biology and Oncology)
New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 5318 | Submission Open
Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy submission deadline 31 Oct 2026 | 6 articles | Viewed by 5222 | Submission Open
Keywords: aortic aneurysms; genetic aortic diseases; endothelial dysfunction; extracellular matrix; aortic wall; aortic smooth muscle; angiotensin system; aortic wall elasticity; matrix metalloproteinases
(This special issue belongs to the Section Molecular and Translational Medicine)
Human Stem Cells in Disease Modelling and Treatment (2nd Edition)
edited by Sofia M. Calado and
submission deadline 31 Oct 2026 | 4 articles | Viewed by 5218 | Submission Open
Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 5065 | Submission Open
Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance
(This special issue belongs to the Section Cancer Biology and Oncology)
Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology
edited by Sevastiani Antonouli and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 4986 | Submission Open
Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges
(This special issue belongs to the Section Gene and Cell Therapy)
Chronic Pain: From Prevention to Therapeutic Strategies—Third Edition
edited by Isaura Tavares and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4607 | Submission Open
Keywords: pain pathophysiology; pain prevention; predictive sensory testing; pre- and postoperative chronic pain; new biomarkers in pain; pain management and novel treatments; preemptive analgesia; inflammatory pain
(This special issue belongs to the Section Molecular and Translational Medicine)
Multisystem Crosstalk in Health and Disease submission deadline 31 Oct 2026 | 1 articles | Viewed by 4488 | Submission Open
Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host–microbe interactions; metabolic regulation
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 4404 | Submission Open
Keywords: mycobacterium; pathogenesis; host–pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance
(This special issue belongs to the Section Microbiology in Human Health and Disease)
New Trends in Regional Anesthesia and Pain Management
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4316 | Submission Open
Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques, technologies, or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith, SPRint PNS system, or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Molecular and Translational Medicine)
Chronic Liver Disease: From Mechanisms to Therapeutic Approaches
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 3700 | Submission Open
Keywords: chronic liver disease; cirrhosis; portal hypertension; hepatocellular carcinoma; variceal bleeding; transjugular intrahepatic portosystemic shunt (TIPS)
(This special issue belongs to the Section Molecular and Translational Medicine)
Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 3165 | Submission Open
Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Recent Advanced Research in Hypertension
edited by Rodrigo Maranon
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2965 | Submission Open
Keywords: hypertension; sex differences; pathophysiology; precision medicine; novel therapeutics; digital health; cardiovascular disease
(This special issue belongs to the Section Cell Biology and Pathology)
Progress in Cytotoxicity of Biomaterials
edited by Lakkamraju Vijayalakshmi
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2682 | Submission Open
Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety
(This special issue belongs to the Section Biomedical Engineering and Materials)
Phenotypes and Endotypes in Interstitial Lung Diseases—Second Edition
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2534 | Submission Open
Keywords: interstitial lung diseases (ILDs); heterogeneity; pathogenesis; progressive pulmonary fibrosis (PPF); molecular biomarkers
(This special issue belongs to the Section Immunology and Immunotherapy)
Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration
edited by , Laxmi Rathor and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2490 | Submission Open
Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans
(This special issue belongs to the Section Cell Biology and Pathology)
New Insights in Immunological Pathways
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2483 | Submission Open
Keywords: immune response; immune signal pathway; cytokine storm
(This special issue belongs to the Section Immunology and Immunotherapy)
Biomarker, Phenotyping and Therapeutics for Asthma
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2456 | Submission Open
Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets
(This special issue belongs to the Section Molecular and Translational Medicine)
From Gut to Vascular Health: The Role of Probiotics, Polyphenols, and Diet in Neuroinflammation and Cardiovascular Dysfunction
edited by Maria Serra and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2179 | Submission Open
Keywords: nutrition supplements; plant extract; polyphenols; oxidative stress; inflammation; neuroinflammation; microbiota; cardiometabolic dysfunction
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Immunotherapy and Immune-Related Adverse Events in Cancer submission deadline 31 Oct 2026 | 1 articles | Viewed by 2169 | Submission Open
Keywords: immunotherapy; cancer; PD-1 inhibitors; immune-related adverse effects; management
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Immunometabolism: Molecular Pathways, Regulatory Networks, and Therapeutic Opportunities submission deadline 31 Oct 2026 | 1 articles | Viewed by 1988 | Submission Open
Keywords: immunometabolism; metabolic reprogramming; immune-cell signaling; inflammation; tumor microenvironment; mitochondrial dysfunction; oxidative stress; immunometabolic checkpoints; biomarkers; targeted therapy
(This special issue belongs to the Section Immunology and Immunotherapy)
Crosstalk Between Depression, Anxiety, Dementia, and Chronic Pain Comorbidity in Behavioral Neurology and Neuropsychiatry—4th Edition
edited by Masaru Tanaka and Simone Battaglia
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1897 | Submission Open
Keywords: depression; anxiety; dementia; chronic pain; Alzheimer’s disease; Parkinson’s disease; multiple sclerosis; stroke; depressive disorder; anxiety disorder; schizophrenia; somatic symptom disorder; antidepressants; anxiolytics; nootropic agents; analgesics; neurodegeneration; neuroprotection; psychotherapy; serotonin; kynurenine
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges submission deadline 31 Oct 2026 | 1 articles | Viewed by 1668 | Submission Open
Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool
(This special issue belongs to the Section Cancer Biology and Oncology)
Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches: 2nd Edition
edited by Yanyun Gao
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1666 | Submission Open
Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Psychiatry and Antipsychotics
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1665 | Submission Open
Keywords: psychiatric diseases; schizophrenia; antipsychotics; molecular psychiatry; molecular pathways; neurotransmitter systems; positive, negative and cognitive symptoms
(This special issue belongs to the Section Molecular and Translational Medicine)
Small Molecules, from Natural Sources, in Drug Discovery
edited by and Cláudia Pinho
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1522 | Submission Open
Keywords: natural products; translational research; drug discovery; herbal therapy; small molecules; therapeutic leads; pharmacology; natural bioactive compounds
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Lung Cancer: From Bench to Bedside (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1317 | Submission Open
Keywords: lung cancer; immunotherapy; targeted therapy; translational oncology; biomarkers; EGFR; ALK; ROS1
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Liver Fibrosis: From Mechanisms to Therapeutics
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1316 | Submission Open
Keywords: liver fibrosis; therapeutic target; biomarker; hepatocyte; macrophage; LSEC; HSC; immune cells; extracellular matrix
(This special issue belongs to the Section Molecular and Translational Medicine)
Pharmacogenetics and Pharmacogenomics: Driving Forces in Modern Precision Medicine
edited by Miriam Saiz-Rodríguez and Dora Koller
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1290 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; polygenic risk scores; phenoconversion; drug response; genetic biomarkers; personalized therapy; underrepresented populations; clinical implementation
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Molecular and Cellular Mechanisms in Metabolic Bone and Cartilage Disorders submission deadline 31 Oct 2026 | 2 articles | Viewed by 1238 | Submission Open
Keywords: metabolic bone; cartilage disorders; osteoporosis; osteoarthritis; impaired fracture healing; rare metabolic skeletal diseases
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Next-Generation CRISPR and Immune Modulation: Advancing Precision Genome Editing Therapies for Genetic Disorders
edited by Sukanta Jash
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1211 | Submission Open
Keywords: CRISPR/Cas9; base editors; prime editors; innate immunity; genome editing; off-target effects; delivery vectors; monogenic disorders; multiplex editing; AI-driven CRISPR
(This special issue belongs to the Section Gene and Cell Therapy)
Molecular Signatures and Therapeutic Strategies in Urological Cancers
edited by Haoyue Sheng
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1185 | Submission Open
Keywords: urological cancers; molecular signatures; precision medicine; non-coding RNAs; tumor microenvironment
(This special issue belongs to the Section Molecular and Translational Medicine)
Pulmonary Arterial Hypertension: From Molecular Basis to Therapeutic Approaches—2nd Edition
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1168 | Submission Open
Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; therapy; vascular disease; translational research
(This special issue belongs to the Section Molecular and Translational Medicine)
Pancreatic Cancer: From Mechanisms to Therapeutic Approaches (4th Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1121 | Submission Open
Keywords: pancreatic cancer; tumor microenvironment; biomarker; immune environment in pancreatic cancer
(This special issue belongs to the Section Cancer Biology and Oncology)
Gynecologic Research: New Diagnostic and Therapeutic Approaches
edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis
submission deadline 31 Oct 2026 | 1 articles | Viewed by 903 | Submission Open
Keywords: precision gynecology; liquid biopsy in gynecologic oncology; fertility preservation; gynecologic cancers; pelvic disorders; hormonal therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets
edited by Jude Taylor
submission deadline 31 Oct 2026 | Viewed by 859 | Submission Open
Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
3D Cell Culture Systems for Biomedical Research, 2nd Edition submission deadline 31 Oct 2026 | 1 articles | Viewed by 787 | Submission Open
Keywords: 3D; scaffolds; spheroids; biomaterials; tumour model; bioengineering; tissue regeneration; regenerative medicine; targeted therapies; tissue mimics; angiogenesis; cancerogenesis; drug development; 3D printing; material functionalisation
(This special issue belongs to the Section Biomedical Engineering and Materials)
Molecular Research in Genitourinary Oncology
edited by , Ioannis Zachos and Vassilios P. Tzortzis
submission deadline 31 Oct 2026 | 1 articles | Viewed by 618 | Submission Open
Keywords: genitourinary oncology; molecular biomarkers; genomics and epigenomics; tumor microenvironment; liquid biopsy
(This special issue belongs to the Section Cancer Biology and Oncology)
Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 605 | Submission Open
Keywords: prostate cancer; androgen deprivation therapy; molecular signaling; epigenetic remodeling; cancer stem cell; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Lymphomas: From Mechanisms to Therapeutic Approaches
edited by Delfa Radić-Krišto and
submission deadline 31 Oct 2026 | Viewed by 550 | Submission Open
Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas
(This special issue belongs to the Section Cancer Biology and Oncology)
Respiratory Infections: New Diagnostic and Therapeutic Approaches
edited by Aleksandar Sovtic
submission deadline 31 Oct 2026 | 1 articles | Viewed by 536 | Submission Open
Keywords: pneumonia; lower respiratory infections; respiratory microbiota; cystic fibrosis; pneumococcal disease; bronchiolitis; pertussis; biofilm
(This special issue belongs to the Section Molecular and Translational Medicine)
Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders
edited by and
submission deadline 31 Oct 2026 | Viewed by 531 | Submission Open
Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut–brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Dopamine in Health and Disease (3rd Edition)
edited by
submission deadline 31 Oct 2026 | Viewed by 464 | Submission Open
Keywords: dopamine; disease models; mitochondria; Parkinson’s disease; schizophrenia
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Current Challenges and Future Perspectives of Antimicrobial Therapy submission deadline 31 Oct 2026 | Viewed by 429 | Submission Open
Keywords: antibiotics; antifungals; antimicrobial resistance; antimicrobial stewardship; drug safety and efficacy; resistance mechanisms
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Molecular Mechanisms of Cardiovascular Diseases (CVDs)
edited by
submission deadline 31 Oct 2026 | Viewed by 391 | Submission Open
Keywords: cardiovascular diseases (CVDs); molecular mechanisms; metabolic dysregulation; immunity; immunometabolism
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarkers and Precision Medicine in Gynecologic Malignancies
edited by Zheng Feng
submission deadline 31 Oct 2026 | Viewed by 378 | Submission Open
Keywords: clinical trials; genomic landscape; targeted therapy; liquid biopsy; tumor screening; biomarker research; artificial intelligence
(This special issue belongs to the Section Cancer Biology and Oncology)
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