Next-Generation Nanoparticles: Innovations in Biomedical Applications and Theranostics

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 55

Special Issue Editor


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Guest Editor
Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam 13120, Gyeonggi‑do, Republic of Korea
Interests: biomaterials; bioactive nanoparticles and nanoconjugates; multidrug-resistant microorganisms
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Special Issue Information

Dear Colleagues,

Nanotechnology is a rapidly expanding field in medical sciences that has various applications in the health sector, particularly for the production of bioactive nanomaterials such as nanoparticles (NPs) and nanoconjugates for controlling several diseases. Green nanotechnology-based NPs and nanoconjugates have attracted huge interest because of their extensive biomedical applications. There are numerous types of nanoparticles, such as silver NPs, gold NPs, zinc oxide NPs, titanium dioxide NPs, cobalt NPs, copper (II) NPs, iron NPs, lithium NPs, and magnesium NPs, etc. The core features of these NPs are their small size with large surface area, modification capability, polarity, and property diversity. The application of these bioactive nanoparticles in the biomedical field offers many revolutionary solutions in the development of multi-functionalized drugs and products to control various diseases. NPs have shown promising results as alternative drugs for human diseases, including cancer, diabetes, wound healing, and infectious diseases. Various physical, chemical, and biological methods are commonly used for synthesizing different types of NPs and nanoconjugates. Among different chemical and physical methods, chemical reduction, electrochemical, physiochemical, and microwave irradiation are usually used for the production of NPs. The synthesis of NPs using macro- and microorganisms, such as extracts of plant parts, bacteria, algae, and fungi, is known as the biosynthesis of NPs. These NPs show a wide range of biomedical applications, such as antioxidant, antimicrobial, anti-inflammation, and anti-cancer agents, as well as promising carriers for various drug delivery systems.

Dr. Md Amdadul Huq
Guest Editor

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Keywords

  • nanoparticles
  • nanoconjugates
  • antimicrobial agents
  • anticancer agents
  • biomedical applications

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Published Papers (1 paper)

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Review

31 pages, 3417 KiB  
Review
Green Synthesis, Characterization, and Potential Antibacterial and Anticancer Applications of Gold Nanoparticles: Current Status and Future Prospects
by Md. Amdadul Huq, Md. Rasel Rana, Abdus Samad, Md. Shahedur Rahman, M. Mizanur Rahman, Md Ashrafudoulla, Shahina Akter and Jong-Whi Park
Biomedicines 2025, 13(5), 1184; https://doi.org/10.3390/biomedicines13051184 - 13 May 2025
Abstract
Drug resistance is a serious problem for human health worldwide. Day by day this drug resistance is increasing and creating an anxious situation for the treatment of both cancer and infectious diseases caused by pathogenic microorganisms. Researchers are trying to solve this terrible [...] Read more.
Drug resistance is a serious problem for human health worldwide. Day by day this drug resistance is increasing and creating an anxious situation for the treatment of both cancer and infectious diseases caused by pathogenic microorganisms. Researchers are trying to solve this terrible situation to overcome drug resistance. Biosynthesized gold nanoparticles (AuNPs) could be a promising agent for controlling drug-resistant pathogenic microorganisms and cancer cells. AuNPs can be synthesized via chemical and physical approaches, carrying many threats to the ecosystem. Green synthesis of AuNPs using biological agents such as plants and microbes is the most fascinating and attractive alternative to physicochemical synthesis as it offers many advantages, such as simplicity, non-toxicity, cost-effectiveness, and eco-friendliness. Plant extracts contain numerous biomolecules, and microorganisms produce various metabolites that act as reducing, capping, and stabilizing agents during the synthesis of AuNPs. The characterization of green-synthesized AuNPs has been conducted using multiple instruments including UV–Vis spectrophotometry (UV–Vis), transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), DLS, and Fourier transform infrared spectroscopy (FT-IR). AuNPs have detrimental effects on bacterial and cancer cells via the disruption of cell membranes, fragmentation of DNA, production of reactive oxygen species, and impairment of metabolism. The biocompatibility and biosafety of synthesized AuNPs must be investigated using a proper in vitro and in vivo screening model system. In this review, we have emphasized the green, facile, and eco-friendly synthesis of AuNPs using plants and microorganisms and their potential antimicrobial and anticancer applications and highlighted their antibacterial and anticancer mechanisms. This study demonstrates that green-synthesized AuNPs may potentially be used to control pathogenic bacteria as well as cancer cells. Full article
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