Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 15 February 2026 | Viewed by 17
Special Issue Editor
Interests: bone regeneration; craniofacial development; stem cell biology; biomaterials; mechanobiology; orthodontics; periodontics; immunomodulation; oxidative stress
Special Issue Information
Dear Colleagues,
The functional regeneration of bone and craniofacial tissues is an area that unites biomaterials science, stem cell and gene therapies, mechanobiology, and clinical disciplines—including orthodontics and oral surgery. Despite advances in scaffold design and bioactive factor delivery, challenges remain in guiding tissue growth under mechanical forces, modulating inflammation and oxidative stress, and translating benchtop breakthroughs into patient‑ready solutions.
This Special Issue will gather cutting‑edge studies relating to the following areas:
- Advanced biomaterials and scaffold fabrication (3D printing and smart/biomimetic materials).
- Stem cell and exosome‑based approaches for osteo‑ and chondrogenesis.
- Mechanobiology—the interface of mechanical loading (e.g., orthodontic forces) and bone remodeling.
- Gene/drug delivery systems targeting osteoinduction, immunomodulation, and redox balance.
- Orthodontic and craniofacial applications, including alveolar bone regeneration during tooth movement.
- Preclinical to clinical translation, covering animal models, pilot trials, and regulatory considerations.
We welcome original research, comprehensive reviews, and expert perspectives that advance our understanding and application of multidisciplinary strategies for bone and craniofacial tissue engineering.
Dr. Zhekai Hu
Guest Editor
Manuscript Submission Information
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Keywords
- bone tissue engineering
- craniofacial regeneration
- biomaterials and scaffolds
- stem cells and exosomes
- mechanobiology and orthodontic forces
- osteoimmunology
- oxidative stress modulation
- gene/drug delivery
- translational research
- periodontal and alveolar bone regeneration
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