Advanced Research in Mitochondrial Medicine and Nanomedicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 128
Special Issue Editor
Interests: anticancer agents; mitochondria; cancer metabolism; nanoparticles; ER stress; natural compounds; synthetic derivatives; antimicrobial agents; targeted therapy
Special Issue Information
Dear Colleagues,
Mitochondria-targeted medicine is an emerging frontier in precision therapy, aiming to improve treatment efficacy and specificity by directing bioactive compounds to these vital organelles. Such targeted approaches enable lower therapeutic doses, reduce systemic toxicity, and help overcome drug resistance, making them highly relevant for the treatment of complex and chronic diseases.
Mitochondria are central regulators of apoptosis, ATP production, redox balance, mitophagy, and cellular homeostasis. Their dysfunction is implicated in a broad range of conditions, including neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), cancer, metabolic syndromes, and cardiovascular pathologies. In these contexts, precise mitochondrial targeting has the potential to modulate disease pathways at their origin. Nanomedicine offers transformative opportunities to achieve this goal, particularly through the development of advanced delivery systems capable of selectively accumulating in mitochondria. Such systems are paving the way for innovative therapies that integrate mitochondrial biology with cutting-edge nanotechnology.
This Special Issue welcomes original research and comprehensive reviews that advance the understanding of mitochondrial medicine and its intersection with nanomedicine. We invite contributions that highlight novel therapeutic targets, innovative delivery platforms, and translational strategies that can bring mitochondria-targeted medicine closer to clinical application.
Dr. Agnieszka Pyrczak-Felczykowska
Guest Editor
Manuscript Submission Information
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Keywords
- nanomedicine
- nanoparticles
- drug delivery
- mitochondria
- cancer
- neurodegenerative disease
- metabolism
- targeted therapy
- mitochondrial function
- bioactive compounds
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