Mitochondrial Function as a Target in Nanomedicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 3
Special Issue Editor
Interests: anticancer agents; mitochondria; cancer metabolism; nanoparticles; ER stress; natural compounds; synthetic derivatives; antimicrobial agents; targeted therapy
Special Issue Information
Dear Colleagues,
The subcellular targeting of bioactive compounds is an advanced strategy in precision medicine that enhances drug efficacy and specificity by directing therapeutics to intracellular sites of disease activity. It allows for lower dosing, reducing systemic toxicity and improving safety. This approach also helps overcome drug resistance and supports combined therapies targeting different organelles.
Mitochondria, as dynamic networks regulating key cellular processes such as apoptosis, ATP synthesis, redox balance, mitophagy, and overall homeostasis, represent a strategic target for therapeutic intervention. Mitochondrial dysfunction is implicated in various diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's, where disruptions in mitochondrial import and protein regulation contribute to pathogenesis. Targeting mitochondria for drug delivery also offers promising avenues in the treatment of cancer as well as metabolic and cardiovascular diseases. However, the effective delivery of therapeutics to these organelles remains a major obstacle in clinical translation. Advances in nanomedicine, particularly in the design of mitochondria-specific delivery systems, offer innovative solutions to enhance therapeutic precision and efficacy in mitochondria-targeted medicine.
This Special Issue aims to explore all facets of mitochondrial-targeted strategies within the field of nanomedicine. We warmly invite researchers to submit original studies and review articles that help to advance knowledge in this area and offer critical insights into the role of mitochondria in contemporary nanotherapeutic approaches.
Dr. Agnieszka Pyrczak-Felczykowska
Guest Editor
Manuscript Submission Information
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Keywords
- nanomedicine
- nanoparticles
- drug delivery
- mitochondria
- cancer
- neurodegenerative disease
- metabolism
- targeted therapy
- mitochondrial function
- bioactive compounds.
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