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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cardiovascular Remodeling: Molecular Mechanisms and Therapeutic Targets

edited by

Elena Kaschina

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5185 | Submission Open

Keywords: cardiac remodeling; vascular remodeling; ageing; pathogenesis; molecular mechanisms; diagnostics; therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches

edited by

Giorgio Sodero

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4960 | Submission Open

Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches, 2nd Edition

edited by

Marie-Lise Maddelein

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4890 | Submission Open

Keywords: neurodegenerative diseases; neurons; mechanism

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Advances in Wound Healing and Skin Regeneration

edited by

Bingrong Zhou

and Siqi Fu

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4624 | Submission Open

Keywords: wound healing; skin regeneration; biomaterials; stem cell therapy; tissue engineering; bioactive dressings; 3D bioprinting; growth factors; chronic wounds; regenerative medicine

Kidney Diseases in Critical Ill Patients

edited by

Caterina Carollo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4610 | Submission Open

Keywords: acute kidney disease; critical care; beside diagnostics; point of care ultrasounds; dialysis

(This special issue belongs to the Section Molecular and Translational Medicine)

Endothelial Dysfunction: From a Pathophysiological Mechanism to a Potential Therapeutic Target—3rd Edition

edited by

Pasquale Ambrosino

and

Guido Grassi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4588 | Submission Open

Keywords: endothelial function; arterial stiffness; vascular medicine; cardiovascular risk; nitric oxide; reactive oxygen species; interleukins; inflammation; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Autophagy, Apoptosis and Cancer: 2025 Update

edited by

Md Ataur Rahman

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4520 | Submission Open

Keywords: autophagy; apoptosis; glioblastoma; hypoxia-inducible factors (HIFs); female fertility and ovarian cancer; nanoparticle-based drug delivery; bioactive natural products

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research on Skeletal Muscle Metabolism

edited by Lorenzo Sanesi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4473 | Submission Open

Keywords: energy metabolism; mebabolic signaling pathways; homeostasis; myokines; aging; atrophy; muscle metabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Biotechnology in the Treatment and Management of Hearing Loss

edited by

Alessandro Castiglione

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4200 | Submission Open

Keywords: hearing loss; gene therapy; regenerative medicine; cochlear implants; nanotechnology stem cell therapy; CRISPR-Cas9; auditory prosthetics; artificial intelligence; auditory regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Application of Artificial Intelligence in Biomedicines

edited by

Raffaele Pugliese

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4150 | Submission Open

Keywords: artificial intelligence; generative artificial intelligence; precision medicine; clinical decision support; drug discovery; personalized therapy; trustworthy AI

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3620 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Mechanisms and Therapeutic Approaches for Hepatocellular Carcinoma

edited by Lanqi Gong,

Xinyuan Guan

and Yu Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3564 | Submission Open

Keywords: hepatocellular carcinoma; HCC diagnosis and prognosis; HCC mechanisms; therapeutic resistance; immunotherapy; targeted therapy; personalized medicine; drug development; clinical trials; translational studies

(This special issue belongs to the Section Cancer Biology and Oncology)

Microcirculation, Thrombosis, and Inflammation in Peripheral Artery Disease and in the Brain

edited by

Patricia Pia Wadowski

and

Henriette Löffler-Stastka

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2881 | Submission Open

Keywords: microcirculation; thrombosis; inflammation; peripheral artery disease; brain

(This special issue belongs to the Section Molecular and Translational Medicine)

Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition

edited by

Aline Yen Ling Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2870 | Submission Open

Keywords: induced pluripotent stem cells; iPSC generation; somatic reprogramming; iPSC-derived cells; cell therapy; exosome therapy; therapeutic application; drug screening

(This special issue belongs to the Section Cell Biology and Pathology)

Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders

edited by

Xuming Zhu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2828 | Submission Open

Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research

(This special issue belongs to the Section Cell Biology and Pathology)

Neuroimmunology and Neurological Infection

edited by

Mariya Ivanovska

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2757 | Submission Open

Keywords: neuroimmunology; neurological infections; immune-mediated diseases; neurodegeneration; biomarkers; immunotherapy; neuroinflammation; clinical neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Advances in Pulmonary Fibrosis

edited by

Mari Ozaki

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2751 | Submission Open

Keywords: pulmonary fibrosis; interstitial lung disease; antifibrotic therapy; precision medicine; imaging diagnostics; novel therapeutics; pathobiology; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology

edited by Sevastiani Antonouli and

Valentina Di Nisio

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2368 | Submission Open

Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges

(This special issue belongs to the Section Gene and Cell Therapy)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2366 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathogenesis and Treatment of Mycobacterium Tuberculosis Infection

edited by Sajid Nadeem

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2299 | Submission Open

Keywords: mycobacterium tuberculosis; pathogenesis; host-directed therapy; inflammation; necrosis; innate and adaptive immunity

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by

Toomas Toomsoo

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2251 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Precision Cancer Therapy

edited by

Yongheng Chen

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2151 | Submission Open

Keywords: personalized cancer therapy; targeted therapy; immunotherapy; cancer genomics; cancer biomarker; liquid biopsy; CAR-T cell therapy; kinase inhibitor; combination therapy; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment

edited by

Guanhu Yang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2014 | Submission Open

Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Congenital Heart Disease: Diagnosis, Treatment and Prognosis

edited by

Gaetano Thiene

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1969 | Submission Open

Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1875 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches

edited by

Santarsiero Anna

Vittoria Infantino

and Paolo Convertini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1769 | Submission Open

Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Adipokines (3nd Edition)

edited by

Christa Büchler

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1673 | Submission Open

Keywords: adiponectin; receptor; agonist; biomarker; inflammation; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

New Insights into Breast Cancer Management: From Tumorigenesis to Personalized Treatments—2nd Edition

edited by

Rita De Sanctis

and

Paola Tiberio

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1493 | Submission Open

Keywords: breast cancer; diagnosis; prognosis; treatment response prediction; biomarkers; risk factors; new therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovations in Nanomedicine for Disease Management

edited by Anna Valentino and

Raffaele Conte

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1427 | Submission Open

Keywords: nanomedicine; nanoparticles; smart drug delivery; personalized medicine; minimally invasive treatments; gene therapy; regenerative medicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Gastric Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatment

edited by Sharona B. Ross

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1278 | Submission Open

Keywords: gastric cancer; tumor microenvironment; molecular mechanism; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives

edited by

Shuchao Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1254 | Submission Open

Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Thyroid Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatment

edited by Sonam Kumari

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1160 | Submission Open

Keywords: radioactive iodine (RAI) treatment; tyrosine kinase inhibitors (TKIs); biomarkers; radiolabeled peptides; diagnostic markers; molecular targets; metastatic progressive thyroid cancer; overcoming resistance; personalized therapies; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Pyroptosis and Cellular Stress: Emerging Mechanisms and Therapeutic Targets

edited by Gang Du

submission deadline 28 Feb 2026 | 1 articles | Viewed by 954 | Submission Open

Keywords: pyroptosis; cellular stress; ROS; programmed cell death; gasdermin; cytokines; inflammation; infection; cellular metabolism; immunometabolism

(This special issue belongs to the Section Cell Biology and Pathology)

Emerging Technologies in Liquid Biopsy of Cancers

edited by Lingdi Yin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 791 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Cannabinoids in Therapeutics: Mechanisms, Signaling Pathways and Personalized Treatment Strategies

edited by

Jan Rožanc

and

Uroš Maver

submission deadline 28 Feb 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: cannabinoids; endocannabinoid system; cancer; pain; inflammation; personalized medicine; receptor signaling; therapeutic development; drug delivery; pharmacogenomics; systems pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Anti-Cancer Agents: Synthesis and Evaluation of Pharmacological Activity

edited by Sureshbabu Popuri

submission deadline 28 Feb 2026 | 1 articles | Viewed by 709 | Submission Open

Keywords: anticancer agents; synthesis; pharmacological evaluation; medicinal chemistry; small molecules; metal complexes; structure– activity relationship (SAR); cytotoxic activity; apoptosis; drug discovery; chemotherapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Peptide Therapeutic Approaches for Cancer Treatment

edited by

Prakash Lingasamy

and

Vijayachitra Modhukur

submission deadline 28 Feb 2026 | Viewed by 626 | Submission Open

Keywords: peptide therapeutics; cancer treatment; drug delivery systems; molecular imaging; bioinformatics; machine learning and artificial intelligence (AI); therapeutic targeting; peptide– drug conjugates; personalized medicine; immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Human Stem Cells in Disease Modelling and Treatment (2nd Edition)

edited by Sofia M. Calado and

Álvaro Plaza Reyes

submission deadline 28 Feb 2026 | 1 articles | Viewed by 618 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Drug Resistance and Novel Targets for Cancer Therapy—Third Edition

edited by

Bruno Kaufmann Robbs

and

Fernando de Carvalho da Silva

submission deadline 28 Feb 2026 | 1 articles | Viewed by 617 | Submission Open

Keywords: cancer; drug resistance; targeted therapy; conventional chemotherapy; natural products; molecular targets; cancer hallmarks; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets

edited by Jude Taylor

submission deadline 28 Feb 2026 | Viewed by 548 | Submission Open

Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Research Progress on Antimicrobial Resistance (AMR)

edited by

Tomohiro Oishi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 527 | Submission Open

Keywords: antimicrobial resistance; mechanism; therapy; experiment; bacteria; antibiotics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Kidney Disease: From Pathophysiology to Treatment

edited by

Paola Pontrelli

and

Francesca Conserva

submission deadline 28 Feb 2026 | 1 articles | Viewed by 527 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; precision medicine; molecular mechanisms; biomarkers; therapeutic response

The Role of Environmental Pollutants in Cancer and Chemoresistance

edited by

Fabio Altieri

and

Margherita Eufemi

submission deadline 28 Feb 2026 | Viewed by 440 | Submission Open

Keywords: environmental pollutants; cancer cells; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances of Amyloid-β Dynamics in Health and Diseases

edited by

Rahat Ullah

submission deadline 28 Feb 2026 | Viewed by 431 | Submission Open

Keywords: Alzheimer’ s disease (AD); amyloid-β clearance; brain and periphery; cerebral amyloid angiopathy (CAA)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Primary and Relapsed Ovarian Cancer

edited by Cornelia Bachmann

submission deadline 28 Feb 2026 | Viewed by 414 | Submission Open

Keywords: ovarian cancer; relapse; BRCA; genetics; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Cancer Treatment

edited by

Vlasios Karageorgos

and

George Liapakis

submission deadline 28 Feb 2026 | Viewed by 351 | Submission Open

Keywords: targeted therapy; bio-conjugates; biologic agents; precision oncology; personalized cancer treatment; biomarker-guided therapy; cancer drug development; biopharmaceuticals

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurotrauma: Mechanisms, Pathways, and Emerging Therapeutic Interventions, 2nd Edition

edited by Kevin Pierre and

Brandon Lucke-Wold

submission deadline 28 Feb 2026 | Viewed by 301 | Submission Open

Keywords: neurotrauma; traumatic brain injury; spinal cord injury; inflammation; oxidative stress; excitotoxicity; diagnostic biomarkers; imaging techniques; neuroprotection; neurogeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Biomedical Engineering for the Elderly

edited by

Siti Anom Ahmad

submission deadline 28 Feb 2026 | Viewed by 299 | Submission Open

Keywords: biomedical engineering; gerontechnology; artificial intelligence in healthcare; digital health; physiological signal processing; human– machine interaction; rehabilitation engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Current Challenges and Future Trends in Intracranial Aneurysms: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Zhongsong Shi and

Aichi Chien

submission deadline 28 Feb 2026 | Viewed by 281 | Submission Open

Keywords: intracranial aneurysm; subarachnoid hemorrhage; inflammation; immune; smooth muscle cell; endothelial dysfunction; hemodynamic forces; biomarkers; neuroimaging; non-coding RNA; multi-omics; endovascular treatment; computational fluid dynamic

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Pathogenesis, Diagnosis and Treatment of Endocrine Cancers

edited by

Rajeev Parameswaran

submission deadline 28 Feb 2026 | Viewed by 255 | Submission Open

Keywords: thyroid; parathyroid; adrenal; paraganglioma; genomes; transcriptomes; signalling pathways; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

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