Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dopamine Signaling Pathway in Health and Disease—2nd Edition submission deadline 30 Nov 2025 | 9 articles | Viewed by 25842 | Submission Open
Keywords: differentiation; disease modeling  ; dopamine and drugs; gene expression; human stem cells; neuronal development; reprogramming; signaling pathways; neurodegeneration; neuromodulation
(This special issue belongs to the Section Molecular and Translational Medicine)
Progress in Neurodevelopmental Disorders Research submission deadline 30 Nov 2025 | 6 articles | Viewed by 21879 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; attention deficit hyperactivity disorder
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition submission deadline 30 Nov 2025 | 6 articles | Viewed by 19310 | Submission Open
Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition
edited by and Valentina Mercurio
submission deadline 30 Nov 2025 | 14 articles | Viewed by 18819 | Submission Open
Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure
(This special issue belongs to the Section Molecular and Translational Medicine)
Women’s Special Issue Series: Biomedicines (2nd Edition) submission deadline 30 Nov 2025 | 5 articles | Viewed by 16623 | Submission Open
Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins
(This special issue belongs to the Section Molecular and Translational Medicine)
The Neuropharmacology of Cannabinoids: Developments in Medicine
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 11796 | Submission Open
Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Feature Reviews on Cardiovascular and Metabolic Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 11788 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; global health; disease prevention; innovative treatments
(This special issue belongs to the Section Cell Biology and Pathology)
Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)
edited by
submission deadline 30 Nov 2025 | 8 articles | Viewed by 11268 | Submission Open
Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches
(This special issue belongs to the Section Cell Biology and Pathology)
The Development of Cancer Immunotherapy
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 9396 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors
(This special issue belongs to the Section Cancer Biology and Oncology)
New Insights into Bone and Cartilage Biology
edited by Vincent Yuan
submission deadline 30 Nov 2025 | 5 articles | Viewed by 8802 | Submission Open
Keywords: bone remodeling; cartilage degeneration; osteoporosis; osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies
(This special issue belongs to the Section Molecular and Translational Medicine)
Wound Healing: From Mechanisms to Therapeutic Approaches
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 8743 | Submission Open
Keywords: wound healing; acute wounds; chronic wounds; keloids; hypertrophic scar; therapies; photobiomodulation; neuroimmunomodulation
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Gastrointestinal Tract Disease Therapies
edited by , Jenwei Chou and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 8362 | Submission Open
Keywords: gut microbiota; fecal microbiota transplantation; inflammatory bowel disease; advanced endoscopy; endoscopic bariatric therapy; endoscopic anti-reflux therapy natural orifice transluminal endoscopic surgery; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Ovarian Physiology and Reproduction
edited by Atefeh Najafi
submission deadline 30 Nov 2025 | 5 articles | Viewed by 8227 | Submission Open
Keywords: ovarian physiology; female fertility; folliculogenesis; oocyte; hormonal regulation; endocrine disruptors; ovarian aging; genetic modifications; environmental factors and female fertility; female reproductive health and disorders
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Vesicles for Diagnosis and Treatment of Human Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7766 | Submission Open
Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights and Latest Advances in Corneal and Ocular Surface Diseases
edited by Isabella M. Y. Cheung and Akilesh Gokul
submission deadline 30 Nov 2025 | 6 articles | Viewed by 7127 | Submission Open
Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery
(This special issue belongs to the Section Molecular and Translational Medicine)
Tendinopathy and Myopathy: From Molecular Basis to Therapy
edited by and Carl Pai Chu Chen
submission deadline 30 Nov 2025 | 2 articles | Viewed by 6668 | Submission Open
Keywords: musculoskeletal disorder; tendinopathy; myopathy
(This special issue belongs to the Section Molecular and Translational Medicine)
Neuroinflammation and Neuroprotection
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6132 | Submission Open
Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Novel Insights into Liver Metabolism submission deadline 30 Nov 2025 | 4 articles | Viewed by 6034 | Submission Open
Keywords: liver; metabolism; oxidative stress; mi-RNAs; cirrhosis; alcohol-related liver disease; autoimmune liver disorders; hepatocellular cancer; liver steatosis; microbiota; diagnostic markers
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Advanced Research on Genitourinary Cancer
edited by Jue Wang
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6016 | Submission Open
Keywords: genitourinary (GU) cancer; prostate; bladder; kidney; and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular and Translational Medicine)
Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches submission deadline 30 Nov 2025 | 2 articles | Viewed by 5775 | Submission Open
Keywords: colorectal cancer; biomarkers; chemotherapy; immunotherapy; liquid biopsy; endoscopy; surgery; microbiota; screening
(This special issue belongs to the Section Cancer Biology and Oncology)
From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology
edited by Iyare Izevbaye
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5622 | Submission Open
Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology
(This special issue belongs to the Section Cancer Biology and Oncology)
Bioinformatics Analysis of RNA for Human Health and Disease
edited by Jihwan Ha
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4762 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
The Art of ART (Assisted Reproductive Technologies) submission deadline 30 Nov 2025 | 4 articles | Viewed by 4545 | Submission Open
Keywords: assisted reproductive technologies; infertility diagnosis; intrauterine insemination (IUI); intracytoplasmic sperm injection (ICSI); in vitro fertilization (IVF); embryo implantation; oocyte quality; preimplantation genetic testing; mitochondrial replacement therapy; follicular recruitment; reproductive medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury
edited by and Xabier Urra
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4400 | Submission Open
Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Diagnostics and Therapy for Malignant Tumors: New Developments
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 4355 | Submission Open
Keywords: metabolites; immunity; microbiome; microenvironment; inflammation
(This special issue belongs to the Section Cancer Biology and Oncology)
Animal Models of Neurological Disorders: Where Are We Now? (3rd Edition)
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4315 | Submission Open
Keywords: animal model of neurological disorders; Parkinson’ s disease; Alzheimer’ s disease; epilepsy; seizures; Huntington’ s disease; schizophrenia
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4195 | Submission Open
Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis
(This special issue belongs to the Section Molecular and Translational Medicine)
Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Second Edition
edited by and Dragos Cozma
submission deadline 30 Nov 2025 | 5 articles | Viewed by 3862 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; thyroid dysfunction; hormonal alterations; endothelial dysfunction; coronary artery disease; hypertension; peripheric arterial disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Bench-to-Bedside Approach to Migraine: How Pathophysiology Could Influence Novel Therapeutic Approaches and Back
edited by Alessandro Vigano and Matteo Castaldo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3844 | Submission Open
Keywords: migraine; comorbidities; pathophysiology; pharmacological interventions; non-pharmacological interventions; chronicization; neurophysiological or neuroimaging for disability or clinical response
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Reproductive Endocrinology and Fertility: From Bench to Bedside
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3631 | Submission Open
Keywords: reproductive health; reproductive system diseases; hormonal regulation; infertility; reproductive dysfunction; reproductive genetics; reproductive physiology; assisted reproductive technologies
(This special issue belongs to the Section Molecular and Translational Medicine)
Neurodegeneration No More: Cutting-Edge Technologies and Therapies in the Evolution of Neurodegenerative Disease Management—2nd Edition submission deadline 30 Nov 2025 | 3 articles | Viewed by 3375 | Submission Open
Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in Genomics and Bioinformatics of Human Disease
edited by Sankarasubramanian Jagadesan
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3286 | Submission Open
Keywords: genomics; bioinformatics; precision medicine; single-cell RNA sequencing; genetic variations; cellular heterogeneity; AI/ML; pathogenicity prediction
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research in Pulmonary Pathophysiology
edited by Ourania S. Kotsiou and Erasmia Rouka
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3251 | Submission Open
Keywords: pathophysiology; aging; disease; injury; microbiome; small airways; pleura; lung cancer; infections; critical care
(This special issue belongs to the Section Cell Biology and Pathology)
Exploring Human Diseases Through Genomic and Genetic Analyses
edited by Fernando Regateiro and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3211 | Submission Open
Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Animal Models for Neurological Disease Research
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3204 | Submission Open
Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways
(This special issue belongs to the Section Molecular and Translational Medicine)
The Role of Iron in Human Diseases
edited by Margherita Correnti
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2945 | Submission Open
Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Role of Natural Product in Cardiovascular Disease—2nd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2711 | Submission Open
Keywords: nature products; phytochemicals; biological and pharmacological activity; cardiovascular disease (CVD) pathogenesis of CVD; risk factors of CVD; metabolic symptom; clinical or preclinical studies
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Periodontal Disease and Periodontal Tissue Regeneration—Second Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 2639 | Submission Open
Keywords: periodontal diagnosis; periodontal immunology; periodontal microbiology; periodontal tissue regeneration; tissue engineering
(This special issue belongs to the Section Biomedical Engineering and Materials)
Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies submission deadline 30 Nov 2025 | 2 articles | Viewed by 2538 | Submission Open
Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches
edited by Yanyun Gao
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2379 | Submission Open
Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models
(This special issue belongs to the Section Cancer Biology and Oncology)
Coronary Artery Disease: From Pathophysiology to Therapeutic Strategies submission deadline 30 Nov 2025 | 2 articles | Viewed by 2343 | Submission Open
Keywords: pathophysiological concept of coronary artery disease; coronary microvascular dysfunction; chronic coronary syndrome; acute coronary syndrome; post-acute coronary syndrome with heart failure; diagnostics in coronary artery disease; therapeutic strategies in CAD; revascularization
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy
edited by , Ednei Luiz Antonio, Gianna Móes de Albuquerque-Pontes and Luis Felipe Neves dos Santos
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2330 | Submission Open
Keywords: cardiomyopathy; cardiac remodeling; heart disease; heart failure; mechanisms; new therapies; targeted therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome
edited by Hermann L. Müller
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2315 | Submission Open
Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae
(This special issue belongs to the Section Cancer Biology and Oncology)
Two Decades of Advances in Colorectal Cancer Prevention and Treatment: From Aspirin to Precision Oncology
edited by and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2045 | Submission Open
Keywords: immunotherapy; biomarkers; colorectal cancer; targeted therapies; molecular pathways
(This special issue belongs to the Section Cancer Biology and Oncology)
Inflammatory Bowel Diseases: New Diagnostic and Therapeutic Approaches—Second Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 1850 | Submission Open
Keywords: bowel inflammation; Crohn’ s disease; endoscopy; inflammatory bowel disease; targeted therapy; ulcerative colitis
(This special issue belongs to the Section Immunology and Immunotherapy)
Molecular Research of Neurological and Psychiatric Disorders
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1804 | Submission Open
Keywords: molecular biology; neurodegenerative disorders; psychiatry; biomarkers; therapeutic targets
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Biomarkers for Neurodegenerative Disorders: From Bench to Bedside
edited by George P. Paraskevas
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1734 | Submission Open
Keywords: dementia; Alzheimer’ s disease; frontotemporal dementia; dementia with Lewy bodies; parkinsonism; tau protein; TDP-43; α -synuclein; Tau-PET; amyloid-PET
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Non-Invasive Brain Stimulation Techniques and Their Application in the Study of Cognitive Function Physiology and Neuro-Psychiatric Rehabilitation
edited by , and Andrea Stefano Moro
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1641 | Submission Open
Keywords: non-invasive brain stimulation; neurophysiology; cognitive function; depression; schizophrenia  
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights in Radiotherapy: Bridging Radiobiology and Oncology
edited by and I-Tsang Chiang
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1625 | Submission Open
Keywords: tissue-sparing effect; bystander effect; factors that affect radiation-induced lethality; radiation-induced abscopal effect; mechanisms that enhance tissue radiosensitivity; synergistic effect from radiotherapy and immunotherapy; regulatory perspectives on medical radiation safety
(This special issue belongs to the Section Cancer Biology and Oncology)
Neurodevelopmental and Neuropsychiatric Disorders in Animal Models
edited by Yael Abreu-Villaça
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1317 | Submission Open
Keywords: mood disorder; mental disorder; substance use disorder; autism spectrum disorder (ASD); attention-deficit/hyperactive disorder (ADHD); depression and anxiety disorders; schizophrenia; bipolar disorder; epilepsy; eating disorders
(This special issue belongs to the Section Molecular and Translational Medicine)
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