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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity—2nd Edition

edited by

Adrian-Bogdan Țigu

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9194 | Submission Open

Keywords: cell death; drug repositioning; translational research; oncology; cancer therapy; apoptosis

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in CAR-T Cell Therapy

edited by

Anand Rotte

submission deadline 30 Jun 2025 | 5 articles | Viewed by 8514 | Submission Open

Keywords: chimeric antigen receptors; CAR-T cells; binding domains; T cells redirected for universal cytokine-mediated killing (TRUCKs); response; CRS; ICANS; safety; cancer; solid tumors; hematological malignancies and autoimmune disorders

(This special issue belongs to the Section Gene and Cell Therapy)

Applications of 3D Cell Culture in Biomedicines

edited by

Yoshitaka Miyamoto

submission deadline 30 Jun 2025 | 3 articles | Viewed by 8338 | Submission Open

Keywords: 3D cell culture; organoid; spheroid; stem cell; transplantation; scaffold; extracellular matrix; biomedicine; regenerative therapy; drug discovery

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Kidney Disease

edited by Andrea Angioi

submission deadline 30 Jun 2025 | 6 articles | Viewed by 8276 | Submission Open

Keywords: kidney disease; glomerular diseases; vasculitis; dialysis; hypertension; pediatric nephrology; transplantation; precision medicine; therapeutic advancements

(This special issue belongs to the Section Molecular and Translational Medicine)

Encephalitis and Viral Infection: Mechanisms and Therapies

edited by Bradley S. Hollidge and

Samantha S. Soldan

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7463 | Submission Open

Keywords: neurovirology; encephalitis; gene therapy; viral vectors; virology; immunology; neuroscience; gene editing

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Women’s Special Issue Series: Biomedicines (2nd Edition)

edited by

Letizia Polito

Federica Falà

and

Riuko Ohashi

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6786 | Submission Open

Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins

(This special issue belongs to the Section Molecular and Translational Medicine)

Autoimmune Diseases and Immune Modulation: Current Research and Future Outlook

edited by

Giuseppe Murdaca

Sebastiano Gangemi

and Francesca Paladin

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6650 | Submission Open

Keywords: CAR and immune system; Treg cells and immune system; SIRT1 and immune system; exosomes and immune system; gut microbiota dysbiosis and immune system; vitamin D and immune system; macrophages/neutrophils and immune system; CAR and autoimmune diseases; Treg cells and autoimmune diseases; SIRT1 and autoimmune diseases; exosomes and autoimmune diseases; gut microbiota dysbiosis and autoimmune diseases; vitamin D and autoimmune diseases; macrophages/neutrophils and autoimmune diseases; EIcircRNAs and autoimmune diseases

(This special issue belongs to the Section Immunology and Immunotherapy)

Epilepsy: From Mechanisms to Therapeutic Approaches

edited by

Prosper N'Gouemo

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6262 | Submission Open

Keywords: genetic epilepsy; acquired epilepsy; neonatal seizures; epileptogenesis; pharmacoresistant epilepsy; ion channels; calcium signaling

(This special issue belongs to the Section Molecular and Translational Medicine)

Kidney Injury/Failure: Molecular Mechanisms and Clues for Intervention

edited by Chang Chu

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5853 | Submission Open

Keywords: acute kidney injury; chronic kidney diseases; molecular mechanisms; cellular mechanisms; new interventions; therapeutic approaches

(This special issue belongs to the Section Cell Biology and Pathology)

Natural and Synthetic Molecules with Anticancer Activity: Pharmacological Basis and Mechanistic Insight

edited by

Hassan Ebrahim

and

Ángela Patricia Hernandez

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5306 | Submission Open

Keywords: anticancer; molecular pharmacology; mechanistic mode of action; signal transduction; in vitro; preclinical; natural products; synthesis

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Molecular Research of Neurodegenerative and Psychiatric Diseases, 2nd Edition

edited by

Dubravka Švob Štrac

submission deadline 30 Jun 2025 | 6 articles | Viewed by 4754 | Submission Open

Keywords: neurodegenerative disorders; psychiatric diseases; biomarkers; therapeutic targets; omics approaches; molecular pathways; cell biology; animal models; clinical studies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Vitamin D in Health and Disease (3rd Edition)

edited by

Giuseppe Murdaca

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4555 | Submission Open

Keywords: vitamin D and the immune system; vitamin D and cytokines; vitamin D and microbiome; vitamin D and respiratory diseases; vitamin D and autoimmune diseases; vitamin D and allergies

(This special issue belongs to the Section Immunology and Immunotherapy)

Pancreatic Cancer: From Mechanisms to Therapeutic Approaches (3rd Edition)

edited by

Satoshi Wada

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4530 | Submission Open

Keywords: pancreatic cancer; tumor microenvironment; biomarker; immune environment in pancreatic cancer

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders

edited by

Marco Gesi

Mario Vetrano

, Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4519 | Submission Open

Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; clinical applications; imaging

(This special issue belongs to the Section Biomedical Engineering and Materials)

The Promise of Artificial Intelligence in Kidney Disease

edited by

Md Mohaimenul Islam

and

Ming-Chin Lin

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4190 | Submission Open

Keywords: artificial intelligence in kidney disease; chronic kidney disease; acute kidney injury; nephrology; prediction model; machine learning; deep learning; renal disease; ultrasound; medical image analysis

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Thyroid Cancer

edited by

Rodis D. Paparodis

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4088 | Submission Open

Keywords: thyroid cancer; thyroid carcinoma; targeted; cancer therapy; biomarker; pathway analyses

(This special issue belongs to the Section Molecular and Translational Medicine)

Signaling of Protein Kinases in Development and Disease

edited by

John Zheng Fu

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3846 | Submission Open

Keywords: kinase; phosphorylation; signaling; mutation; mechanism; development; inhibitor; disease

(This special issue belongs to the Section Cell Biology and Pathology)

Applications and Perspectives of Cold Electric Discharge Plasmas in Biomedicine and Bioengineering

edited by

Andrei Vasile Nastuta

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3567 | Submission Open

Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Biomarkers in Inflammatory Bowel Disease: Pathophysiology and New Therapeutic Strategies—Second Edition

edited by

Marino Vilović

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3471 | Submission Open

Keywords: inflammatory bowel disease (IBD); Crohn’ s disease; ulcerative colitis; biomarkers; molecular biomarkers in IBD; pathophysiology; therapeutic approaches in IBD; precision medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Targeted Delivery of Nanoparticles via Blood Vessels

edited by Avishek Singh

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3429 | Submission Open

Keywords: nanoparticle delivery; transcellular transport; vascular permeability; nanoparticles; endothelial cells

(This special issue belongs to the Section Nanomedicine and Nanobiology)

New Insights into Bone and Cartilage Biology

edited by Vincent Yuan

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3338 | Submission Open

Keywords: bone remodeling; cartilage degeneration; osteoporosis; osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanoparticle-Based Drug Delivery in Cancer Therapy: Current Progress and Challenges

edited by

Menghuan Tang

and

Zhaoqing Cong

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3279 | Submission Open

Keywords: nanoparticle; targeted drug delivery; controlled release; clinical translation; drug resistance; nanomedicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Neurotransmitters in Health and Diseases

edited by

Zsolt Bagosi

and Krisztina Csabafi

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3069 | Submission Open

Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights into Upper Tract Urothelial Carcinoma: What Changed?

edited by Sisto Perdonà and

Antonio Tufano

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2765 | Submission Open

Keywords: upper urinary tract urothelial carcinoma; radical nephroureterectomy; ureterectomy; UTUC; metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Cardiovascular and Metabolic Disease: New Treatment and Future Directions—4th Edition

edited by

Alfredo Caturano

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2506 | Submission Open

Keywords: cardiovascular disease; metabolic disease; diabetes; therapy; drugs; implantable device; heart failure; heart transplantation; cardiac surgery; future directions

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Mechanisms and Novel Therapies for Brain Injury: 2nd Edition

edited by

Arjun Sapkota

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2313 | Submission Open

Keywords: stroke; spinal cord injury; traumatic brain injury; seizure; brain tumors; neurodegeneration; neuroinflammation; blood– brain barrier disruption; neuroprotection; drug discover; mechanism of action; target validation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Protein Therapeutics

edited by Iman Tavassoly

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2260 | Submission Open

Keywords: biologics; monoclonal antibodies; recombinant proteins; therapeutic peptides; protein engineering; protein therapeutics

(This special issue belongs to the Section Gene and Cell Therapy)

Advanced Research into Adipose‐Derived Stem Cells

edited by

Anna Barbara Di Stefano

and Mara Franza

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2244 | Submission Open

Keywords: adipose stem cells; regenerative medicine; stemness; differentiative potential; pre-clinical and clinical applications

(This special issue belongs to the Section Molecular and Translational Medicine)

Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Serafino Fazio

and Valentina Mercurio

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2222 | Submission Open

Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies

(This special issue belongs to the Section Molecular and Translational Medicine)

Antioxidant Materials with Additional Biological Properties

edited by

Nurettin Sahiner

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2141 | Submission Open

Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advanced Research on Heart Failure and Heart Transplantation

edited by

Nandan Kumar Mondal

submission deadline 30 Jun 2025 | 3 articles | Viewed by 1960 | Submission Open

Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Imaging and Neurochemical Biomarkers in Parkinsonian Disorders

edited by

Vasilios C. Constantinides

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1912 | Submission Open

Keywords: progressive supranuclear palsy; multiple system atrophy; corticobasal syndrome; CSF biomarkers; MRI; PET-CT; dopamine transporter imaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury

edited by

Hatice Kumru

and Xabier Urra

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1681 | Submission Open

Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Antiretroviral Research

edited by Massimiliano Lanzafame

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1428 | Submission Open

Keywords: antiretroviral therapy; short cycle therapy; HIV infection; long-acting agents

(This special issue belongs to the Section Cell Biology and Pathology)

Kidney Diseases in Critical Ill Patients

edited by

Caterina Carollo

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1336 | Submission Open

Keywords: acute kidney disease; critical care; beside diagnostics; point of care ultrasounds; dialysis

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Genetic Research and Molecular Diagnostics for Hematological Diseases

edited by Ying S. Zou and Leonard N. Yenwongfai

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1309 | Submission Open

Keywords: hematological diseases; genetic research; benign hematology; inherited disorders; next-generation sequencing/long-read sequencing; optical genome mapping; transcriptome; proteomics; digital pathology; deep convolutional neural networks

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

The Molecular Basis of the Immune Response in Pulmonary Fibrosis

edited by

Tamara Cruz

and

Fernanda Hernandez

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1204 | Submission Open

Keywords: immune response; fibrosis; aging; senescence

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Therapeutic Strategies in Gynecological Malignant Tumors—2nd Edition

edited by

Alberto Farolfi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1015 | Submission Open

Keywords: targeted therapy; precision medicine; gynecological cancers; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Biology and Oncology)

Triple Negative Breast Cancer: From Mechanisms to Therapeutic Approaches

edited by Emad Rakha and Padmashree Rida

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1015 | Submission Open

Keywords: triple-negative breast cancer; neoadjuvant; adjuvant; chemotherapy; immunotherapy; antibody– drug conjugates; immune checkpoint inhibitors; DNA damage; EGFR; FGFR; microtubule dynamics; centrosome amplification

(This special issue belongs to the Section Cancer Biology and Oncology)

State-of-the-Art Neonatal Medicine in Japan

edited by

Fumihiko Namba

submission deadline 30 Jun 2025 | 1 articles | Viewed by 783 | Submission Open

Keywords: mesenchymal stromal cells; artificial placenta; therapeutic gasses; animal models; off-label drug use

(This special issue belongs to the Section Molecular and Translational Medicine)

Adult Congenital Heart Disease: Diagnosis, Treatment and Prognosis

edited by

Gaetano Thiene

submission deadline 30 Jun 2025 | 1 articles | Viewed by 690 | Submission Open

Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

Unraveling the Role of Glucocorticoid Receptor in Inflammation and Cancer

edited by

Dimitra Mitsiou

submission deadline 30 Jun 2025 | Viewed by 584 | Submission Open

Keywords: glucocorticoids; glucocorticoid receptor; inflammation; anti-inflammatory action; pro-inflammatory action; cancer; tumor-promoting inflammation; onco-suppressive action; oncogenic action; selective glucocorticoid receptor agonists/modulators

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Genomics of Oral Submucous Fibrosis Pathology

edited by Sanjit Mukherjee

submission deadline 30 Jun 2025 | Viewed by 564 | Submission Open

Keywords: oral submucous fibrosis; gene expression; biomarker; DNA methylation; epigenetic drugs; immune biomarkers; pathology; therapeutic interventions; epithelial mesenchymal transition; cancer stem cell marker

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Immunology and Immunotherapy in Europe (2nd Edition)

edited by

Juan Gambini

submission deadline 30 Jun 2025 | Viewed by 562 | Submission Open

Keywords: immunology; immunotherapy; lymphocytes; macrophages; eosinophils; neutrophils; diseases

(This special issue belongs to the Section Immunology and Immunotherapy)

Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition

edited by

Aline Yen Ling Wang

submission deadline 30 Jun 2025 | Viewed by 478 | Submission Open

Keywords: induced pluripotent stem cells; iPSC generation; somatic reprogramming; iPSC-derived cells; cell therapy; exosome therapy; therapeutic application; drug screening

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Endocrine Disease and Atherosclerosis

edited by

Sergio Martínez-Hervás

submission deadline 30 Jun 2025 | Viewed by 364 | Submission Open

Keywords: diabetes; dyslipidemia; obesity; insulin resistance; subclinical atherosclerosis; atherosclerosis; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Crohn’s Disease, the Microbiome and Infections: Mechanisms, Novel Diagnostic and Therapeutic Strategies for Pathology

edited by

Roger Pickup

and

Gaurav Agrawal

submission deadline 30 Jun 2025 | Viewed by 355 | Submission Open

Keywords: infections; gut microbiome; Mycobacterium paratuberculosis; Crohn’ s disease; ulcerative colitis; innate immunity; diagnostics culture; molecular

(This special issue belongs to the Section Cell Biology and Pathology)

Exploring Breakthroughs in Intestinal Mucosal Repair and Regeneration

edited by

Lixia He

submission deadline 30 Jun 2025 | Viewed by 316 | Submission Open

Keywords: intestinal mucosal repair; inflammatory bowel disease (IBD); stem cell regeneration; gut microbiota and healing; tissue engineering in gastroenterology; nutritional therapy for mucosal health; biomarkers of mucosal damage; novel therapeutic interventions; mucosal immunology; epithelial barrier function

(This special issue belongs to the Section Immunology and Immunotherapy)

Emerging Research in Dyslipidemia and Hemodialysis: Novel Approaches and Treatment Strategies

edited by Leszek Niepolski

submission deadline 30 Jun 2025 | Viewed by 306 | Submission Open

Keywords: dyslipidemia; end-stage renal disease; hemodialysis; lipid-lowering therapy; lipoproteins

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of MicroRNAs in Adult Skeletal Muscle

edited by Ivan J. Vechetti

submission deadline 30 Jun 2025 | Viewed by 302 | Submission Open

Keywords: skeletal muscle; miRNAs; regeneration; aging; atrophy; hypertrophy

(This special issue belongs to the Section Molecular and Translational Medicine)

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