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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Bone Marrow Niche in Haematological Cancers

edited by

Jehan J. El-Jawhari

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4780 | Submission Open

Keywords: blood cancers; bone marrow; microenvironment; immune stromal interactions; mesenchymal stem cells

(This special issue belongs to the Section Cancer Biology and Oncology)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (2nd Edition)

edited by

Fernando Cardona

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4597 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Cardiovascular Pharmacology

edited by

Pietro Scicchitano

and

Francesco Massari

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4428 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pharmacology; target therapies; molecular pharmacology; heart failure; preventive cardiology; atherosclerosis

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Bioactive Peptides and Derivatives as Therapeutic Agents: Potential Applications in Disease Treatment

edited by

Toshihiro Kita

submission deadline 31 Aug 2025 | 1 articles | Viewed by 3881 | Submission Open

Keywords: bioactive peptide; peptide modification; application; cardiovascular disease; inflammatory disease; digestive disease; neurological disease; drug development

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Adiposity, Inflammation, and Metabolic Regulation: Molecular Mechanisms and Therapeutic Strategies

edited by

Qianfen Wan

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3834 | Submission Open

Keywords: adipose tissue; inflammation; obesity and its metabolic complications; obesity pathogenesis

(This special issue belongs to the Section Molecular and Translational Medicine)

Connective Tissue Disorders: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Katarzyna Winsz-Szczotka

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3597 | Submission Open

Keywords: connective tissue disorders; pathophysiological mechanisms; inflammation; autoimmunity; extracellular matrix; fibrosis; biomarkers; treatment; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Crohn’s Disease and Ulcerative Colitis: From Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Dingpei Long

and Junsik Sung

submission deadline 31 Aug 2025 | 5 articles | Viewed by 3488 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; chronic inflammation; pathophysiological mechanisms; therapeutic approaches; stem cell transplantation; fecal microbiota transplantation; gut microbiome; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

MicroRNAs as Mediators of Tumor Cell State Transitions, Receptor Remodeling, Drug Resistance, and Systemic Metastasis

edited by

Vinitha Richard

and Michael J. Kerin

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3310 | Submission Open

Keywords: solid epithelial tumors; cancer stem cells; microRNAs; epigenetics; cell state transitions; chemoresistance; immunosuppression; tumor microenvironment; metastasis

(This special issue belongs to the Section Cancer Biology and Oncology)

Platelets in Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by Henry Nording

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3207 | Submission Open

Keywords: platelet biology; vascular immunity; atherosclerosis; therapeutic targets; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Liquid Biopsy from Technological Innovation to Therapeutic Intervention

edited by

Mohamed Kamal

and

James Hicks

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2703 | Submission Open

Keywords: liquid biopsy; biomarkers; circulating tumor cells

(This special issue belongs to the Section Molecular and Translational Medicine)

Animal Models for the Study of Human Diseases

edited by

Yong-He Ding

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2437 | Submission Open

Keywords: animal models; zebrafish; mice; rats

(This special issue belongs to the Section Molecular and Translational Medicine)

Drug Resistance and Tumor Microenvironment in Human Cancers

edited by

Tiago Miguel Amaral Carvalho

Silvia Socorro

and Marília Isabel Neto Figueira

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2280 | Submission Open

Keywords: cancer therapy; drug resistance; tumor microenvironment; targeted therapy; precision medicine; cancer-related mechanisms

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research on Fibromyalgia (3rd Edition)

edited by

Elena Lucarini

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2248 | Submission Open

Keywords: fibromyalgia; chronic fatigue syndrome; myofascial pain syndrome; diagnostic biomarkers; biomarkers for predicting treatment response; disability; rehabilitation; chronic pain; mutations and polymorphisms of genes related to fibromyalgia; epigenetics

(This special issue belongs to the Section Molecular and Translational Medicine)

Meningioma: Novel Diagnostic and Therapeutic Approaches

edited by Carlen A. Yuen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2232 | Submission Open

Keywords: meningioma; atypical; anaplastic; PET DOTATATE; octreotide; Lutetium-177; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advancements in Induced Pluripotent Stem Cells

edited by

M. Esther Gallardo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2122 | Submission Open

Keywords: induced pluripotent stem cells; organoids; tissue engineering; biomaterials; reprogramming; iPSC-based cell modelling; cell therapy; microfluidics; drug discovery

(This special issue belongs to the Section Gene and Cell Therapy)

Lipids and Lipid Metabolism in Cardiovascular Health and Disease

edited by Fei Luo

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2113 | Submission Open

Keywords: lipids; lipoproteins; lipid metabolism; cardiovascular health and disease; atherosclerotic cardiovascular disease; lipid-lowering therapy; triglyceride-lowering therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Skeletal Muscle Metabolism

edited by Lorenzo Sanesi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2052 | Submission Open

Keywords: energy metabolism; mebabolic signaling pathways; homeostasis; myokines; aging; atrophy; muscle metabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Pediatric Ocular Pathology and Treatment

edited by Hyun-jin Shin

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2046 | Submission Open

Keywords: pediatric ophthalmology; eye diseases; genetics; medical; diagnostic techniques; ophthalmological; therapeutics

(This special issue belongs to the Section Cell Biology and Pathology)

Biotechnology in the Treatment and Management of Hearing Loss

edited by

Alessandro Castiglione

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1968 | Submission Open

Keywords: hearing loss; gene therapy; regenerative medicine; cochlear implants; nanotechnology stem cell therapy; CRISPR-Cas9; auditory prosthetics; artificial intelligence; auditory regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advancements in Brain Diagnosis and Treatment: From Insights to Innovations

edited by Irene Chaves-Coira and

Brandon Lucke-Wold

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1959 | Submission Open

Keywords: brain diagnosis and treatment; underlying mechanisms; individualized treatment

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in the Discovery of Novel Drugs on Natural Molecules, Second Edition

edited by

Laura Quintieri

Leonardo Caputo

and

Orazio Nicolotti

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1814 | Submission Open

Keywords: natural compounds; bioactive peptides; peptidomimetics; microbial metabolites; polyphenols; genome mining; molecular modeling; therapeutic uses

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Polycystic Ovary Syndrome Research: From Molecular Mechanisms to Therapeutic Strategies—2nd Edition

edited by

Ebrahim Asadi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1783 | Submission Open

Keywords: female infertility; endocrine disorder; metabolic disorder; polycystic ovary syndrome; polycystic ovariany morphology; hyperandrogenism; menstrual irregularity; theraputicsTherapeutics; oxidative stress; antioxidant

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathogenesis, Diagnosis and Treatment of Infectious Diseases

edited by

Laura Franza

submission deadline 31 Aug 2025 | 3 articles | Viewed by 1715 | Submission Open

Keywords: infection; infectious diseases; vaccination; antibiotics; antibiotic resistance; novel therapies; novel diagnosis; inflammaging; immunosenescence

(This special issue belongs to the Section Molecular and Translational Medicine)

Microbial Infections and Sepsis: Pathophysiological Mechanisms and Therapeutic Approaches

edited by

Nirupam Biswas

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1702 | Submission Open

Keywords: sepsis; cytokines; inflammation; bacteria; stem cell; molecular biology; flow cytometry; multiplex; MALDI-TOF-MS; RT-PCR

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Emerging Trends in the Study of Inherited Metabolic Disorders

edited by Sudeep Gautam

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1662 | Submission Open

Keywords: inherited metabolic disorders; glycogen storage diseases; genetically modified mouse models; liver and kidney disease; hepatocellular carcinoma; autophagy; diabetes mellitus; patient-derived organoids; gene therapy

(This special issue belongs to the Section Gene and Cell Therapy)

Mechanisms and Therapeutic Approaches for Hepatocellular Carcinoma

edited by Lanqi Gong,

Xinyuan Guan

and Yu Zhang

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1477 | Submission Open

Keywords: hepatocellular carcinoma; HCC diagnosis and prognosis; HCC mechanisms; therapeutic resistance; immunotherapy; targeted therapy; personalized medicine; drug development; clinical trials; translational studies

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Cardiovascular Remodeling: Molecular Mechanisms and Therapeutic Targets

edited by

Elena Kaschina

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1358 | Submission Open

Keywords: cardiac remodeling; vascular remodeling; ageing; pathogenesis; molecular mechanisms; diagnostics; therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Gliomas: Signaling Pathways, Molecular Mechanisms and Novel Therapies (2nd Edition)

edited by

Hung-Pei Tsai

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1238 | Submission Open

Keywords: glioma; molecular pathology; blood– brain barrier; immunotherapy; microenvironment; nanomedicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Immune Cell Biology: Insights from Molecular Perspectives

edited by

Paolo Fagone

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1195 | Submission Open

Keywords: immune cell biology; cell signaling cascades; autoimmune disorders; immunoinflammatory pathways; hematological disorders

(This special issue belongs to the Section Cell Biology and Pathology)

Brain Imaging and Cognitive Deficits in Psychiatric Disorders, 2nd Edition

edited by

Wenbin Guo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1033 | Submission Open

Keywords: cognitive deficits; psychiatric disorders; schizophrenia; brain imaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Immunopharmacy

edited by

Po-Jen Chen

and Shun-Hua Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 979 | Submission Open

Keywords: immunopharmacy; immunopharmacology; immunomodulation; pharmacological intervention; immunotherapy; drug– immune system interaction; vaccine development; personalized pharmacotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

New Perspectives in the Treatment of Head and Neck Vascular Malformations

edited by Paolo Gennaro

submission deadline 31 Aug 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: vascular anomalies; vascular malformations; AVMs; venous malformations; electrosclerotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Biomedical Engineering for the Aging Population

edited by

Weichih Lien

and Wen-Fong Wang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: biomedical engineering; geriatric engineering; senescence; regenerative medicine; rehabilitation

(This special issue belongs to the Section Biomedical Engineering and Materials)

The Role of Immune Response in the Protection Against SARS-CoV-2 Infection

edited by

Cinzia Giagulli

submission deadline 31 Aug 2025 | 1 articles | Viewed by 738 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immune response; innate immune system; adaptative response; vaccines

(This special issue belongs to the Section Immunology and Immunotherapy)

Biomedicine in Dental and Oral Rehabilitation

edited by

Sanda Mihaela Popescu

and

Mihaela Ionescu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 729 | Submission Open

Keywords: diagnosis; treatment; oral rehabilitation; dental and oral disease; biomedicine; biomaterial; regeneration; functional; esthetics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multiple Sclerosis: Diagnosis and Treatment—3rd Edition

edited by

Víctor M. Rivera

submission deadline 31 Aug 2025 | 1 articles | Viewed by 718 | Submission Open

Keywords: multiple sclerosis; pathogenesis; progressive MS; MRI; disease-modifying therapies; demyelinating disorders; cognitive dysfunction; intestinal microbiota

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Osteoarthritis: Molecular Pathways and Novel Therapeutic Strategies—2nd Edition

edited by

Antonia Patruno

Teresa Paolucci

Mirko Pesce

and Andrea Pantalone

submission deadline 31 Aug 2025 | 1 articles | Viewed by 705 | Submission Open

Keywords: osteoarthritis; cartilage; pain; orthopedics; rehabilitation

(This special issue belongs to the Section Molecular and Translational Medicine)

Imaging Technology for Human Diseases

edited by Emanuele David

submission deadline 31 Aug 2025 | 1 articles | Viewed by 640 | Submission Open

Keywords: technological advances; imaging; X-ray; mammography; CT; MRI; ultrasound; angiography

(This special issue belongs to the Section Biomedical Engineering and Materials)

Emerging Insights in Thoracic Diseases: From Diagnostics to Biomarkers and Therapeutic Implications Through Interdisciplinarity

edited by

Radu Adrian Crisan-Dabija

and

Alexandru Burlacu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 548 | Submission Open

Keywords: chronic obstructive pulmonary disease; acute respiratory diseases; cardionephrology; interstitial lung disease; interventional cardiology; pulmonary fibrosis; tuberculosis; research methodology; biomarkers; therapeutics; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Hypertension, Hypercholesterolemia and Type 2 Diabetes—2nd Edition

edited by

Tomislav Bulum

submission deadline 31 Aug 2025 | Viewed by 491 | Submission Open

Keywords: type 2 diabetes; hypertension; LDL-cholesterol; serum lipids; metabolic syndrome; cardiovascular disease; chronic complications; nephropathy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 31 Aug 2025 | 1 articles | Viewed by 474 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Feature Reviews in Target Identification and Drug Discovery

edited by

Fabio Altieri

submission deadline 31 Aug 2025 | Viewed by 437 | Submission Open

Keywords: drug discovery; biological target; bioactive compounds; pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Peptide Therapeutic Approaches for Cancer Treatment

edited by

Prakash Lingasamy

and

Vijayachitra Modhukur

submission deadline 31 Aug 2025 | Viewed by 389 | Submission Open

Keywords: peptide therapeutics; cancer treatment; drug delivery systems; molecular imaging; bioinformatics; machine learning and artificial intelligence (AI); therapeutic targeting; peptide– drug conjugates; personalized medicine; immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advancements in the Treatment of Mesothelioma

edited by

Luciano Mutti

submission deadline 31 Aug 2025 | Viewed by 347 | Submission Open

Keywords: mesothelioma; targeted therapy; diagnostics; checkpoint inhibitors; immunotherapy; chemotherapy; combination therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Antiviral Innate Immunity

edited by Junji Zhu

submission deadline 31 Aug 2025 | Viewed by 331 | Submission Open

Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Related Diseases

edited by

Pankaj Patyal

and Gohar Azhar

submission deadline 31 Aug 2025 | Viewed by 298 | Submission Open

Keywords: mitochondrial dysfunction; aging; reactive oxygen species; mitochondrial dynamics; mitophagy; mitochondrial biogenesis; age-related disorders

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Respiratory Allergies: Insights from Molecular Perspectives

edited by Sara Manti and

Salvatore Leonardi

submission deadline 31 Aug 2025 | Viewed by 295 | Submission Open

Keywords: pediatrics; allergology; pulmounology; acute and chronic respiratory diseases; congenital and acquired respiratory diseases; novel treatment.

(This special issue belongs to the Section Immunology and Immunotherapy)

New Trends in Regional Anesthesia and Pain Management

edited by

Jui-An Lin

submission deadline 31 Aug 2025 | Viewed by 292 | Submission Open

Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques; technologies; or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith; SPRint PNS system; or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Environmental Pollutants in Cancer and Chemoresistance

edited by

Fabio Altieri

and

Margherita Eufemi

submission deadline 31 Aug 2025 | Viewed by 276 | Submission Open

Keywords: environmental pollutants; cancer cells; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Roles of Extracellular Vesicles in Cancer Immunotherapy

edited by Shujing Liu and Zhiyuan Qin

submission deadline 31 Aug 2025 | Viewed by 272 | Submission Open

Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery

(This special issue belongs to the Section Cancer Biology and Oncology)

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