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  • Review
  • Open Access
152 Citations
42,669 Views
31 Pages

The purpose of this literature review is to provide a fundamental synopsis of current research pertaining to artificial intelligence (AI) within the domain of clinical practice. Artificial intelligence has revolutionized the field of medicine and hea...

  • Review
  • Open Access
16 Citations
22,249 Views
34 Pages

Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

  • Natália M. de Oliveira,
  • Jorge Machado,
  • Maria Helena Chéu,
  • Lara Lopes and
  • Maria Begoña Criado

22 September 2024

The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate is highly favorable to the synthesis of phenolic compounds, stored in olive leaves; their consumption has been linked to a lower incidence of...

  • Review
  • Open Access
5 Citations
14,283 Views
14 Pages

Distraction Osteogenesis: A Comprehensive Review

  • Babapelumi Adejuyigbe,
  • Mohini Gharpure,
  • Charlotte F. Wahle and
  • Jennifer R. Kallini

21 November 2024

Distraction osteogenesis (DO) is a process which uses the bone’s natural healing tendencies to repair and lengthen pathologic, missing, or malformed bone. The mechanism of DO mimics the pathway that the body uses in any other fracture repair ho...

  • Review
  • Open Access
33 Citations
13,971 Views
17 Pages

24 November 2023

Circular dichroism (CD) spectroscopy has emerged as a powerful tool in the study of protein folding, structure, and function. This review explores the versatile applications of CD spectroscopy in unraveling the intricate relationship between protein...

  • Article
  • Open Access
1 Citations
11,037 Views
12 Pages

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

  • Philip A. Sapp,
  • Jeremy R. Townsend,
  • Trevor O. Kirby,
  • Marlies Govaert,
  • Cindy Duysburgh,
  • Massimo Marzorati,
  • Tess M. Marshall and
  • Ralph Esposito

1 December 2023

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. The purpose of this study was...

  • Review
  • Open Access
18 Citations
10,023 Views
32 Pages

A Review of Deep Learning Techniques for Leukemia Cancer Classification Based on Blood Smear Images

  • Rakhmonalieva Farangis Oybek Kizi,
  • Tagne Poupi Theodore Armand and
  • Hee-Cheol Kim

This research reviews deep learning methodologies for detecting leukemia, a critical cancer diagnosis and treatment aspect. Using a systematic mapping study (SMS) and systematic literature review (SLR), thirty articles published between 2019 and 2023...

  • Article
  • Open Access
19 Citations
9,803 Views
14 Pages

4 December 2023

Exploratory data analysis and statistical moments were used to investigate the potential impact of ceiling and floor effects in medical trials. A total of 150 treatment-naive eyes were assessed in a retrospective case study of patients who were treat...

  • Review
  • Open Access
44 Citations
9,480 Views
15 Pages

The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview

  • Sara Ricardo-Rodrigues,
  • Maria Inês Rouxinol,
  • Ana Cristina Agulheiro-Santos,
  • Maria Eduarda Potes,
  • Marta Laranjo and
  • Miguel Elias

6 February 2024

Consumers are looking for safer and more natural food options that are produced through natural methods without using synthetic preservatives. They also desire extended shelf life for their food products. Several medicinal and aromatic plants species...

  • Article
  • Open Access
17 Citations
8,907 Views
20 Pages

Phytochemical Screening, Polyphenol and Flavonoid Contents, and Antioxidant and Antimicrobial Activities of Opilia amentacea Roxb. (Opiliaceae) Extracts

  • Ollo Youl,
  • Belinda Ramata Hafouo Moné-Bassavé,
  • Sibidou Yougbaré,
  • Boubacar Yaro,
  • Tata Kadiatou Traoré,
  • Rainatou Boly,
  • Josias B. Gérard Yaméogo,
  • Moumouni Koala,
  • Noufou Ouedraogo and
  • Adama Hilou
  • + 3 authors

6 September 2023

Dermatoses are essentially caused by infection or free radical aggression, immunoallergic disorders, or can be secondary to general diseases. Management of dermatoses by modern medicine is complex and costly, and the development of alternative treatm...

  • Review
  • Open Access
3 Citations
8,490 Views
21 Pages

Immune thrombocytopenia, formerly idiopathic thrombocytopenia purpura (ITP), is an autoimmune disease characterized by the depletion of platelets below 100,000/µL when other causes of thrombocytopenia have been ruled out. It is associated with...

  • Review
  • Open Access
11 Citations
7,830 Views
21 Pages

25 October 2023

Single Nucleotide Polymorphisms (SNPs) are variations that occur at single nucleotides in the genome and are present at an appreciable level in a population. SNPs can be linked to phenotypes of interest, for example diseases, recent adaptations, or s...

  • Review
  • Open Access
33 Citations
7,814 Views
26 Pages

Wine Grapes Ripening: A Review on Climate Effect and Analytical Approach to Increase Wine Quality

  • Maria Inês Rouxinol,
  • Maria Rosário Martins,
  • João Mota Barroso and
  • Ana Elisa Rato

Red wine grapes have an important impact on the economy of many regions, both for wine quality and for their richness in phenolic compounds, which have many health benefits. Climate has been changing substantially in the last years, which affects gre...

  • Article
  • Open Access
9 Citations
7,499 Views
17 Pages

Green Synthesis and Characterization of Iron Oxide Nanoparticles Using Egeria densa Plant Extract

  • Maruf Olaide Yekeen,
  • Mubarak Ibrahim,
  • James Wachira and
  • Saroj Pramanik

An aqueous leaf extract of Egeria densa was used to green-synthesize iron (II) and iron (III) oxide nanoparticles from ferrous sulphate and ferric chloride, respectively. The successful green synthesis of the nanoparticles was confirmed through UV&nd...

  • Feature Paper
  • Review
  • Open Access
10 Citations
7,005 Views
18 Pages

Deregulations of RNA Pol II Subunits in Cancer

  • Martina Muste Sadurni and
  • Marco Saponaro

24 August 2023

Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being a common feature of several cancers. Often, deregulated transcription is a consequence of alterations in transcription factors (TFs),...

  • Article
  • Open Access
2 Citations
5,913 Views
20 Pages

Comparison of Culture Media for In Vitro Expansion of Oral Epithelial Keratinocytes

  • Giancarlo A. Cuadra,
  • Abrar Shamim,
  • Raivat Shah,
  • Joey Morgan and
  • Dominic L. Palazzolo

Background: Expansion of OKF6/TERT-2 oral epithelial cells in vitro is important for studying the molecular biology of disease and pathology affecting the oral cavity. Keratinocyte serum-free medium (KSFM) is the medium of choice for this cell line....

  • Article
  • Open Access
12 Citations
5,820 Views
12 Pages

Fostering Resilience and Wellness: The Synergy of Mindful Eating and the Mediterranean Lifestyle

  • Efstratios Christodoulou,
  • Georgia-Eirini Deligiannidou,
  • Christos Kontogiorgis,
  • Constantinos Giaginis and
  • Antonios E. Koutelidakis

17 January 2024

Increasing evidence indicates that the cultivation of mindful eating, adherence to the Mediterranean lifestyle, and the development of psychological resilience may contribute to the enhancement of overall health and well-being. The purpose of this st...

  • Review
  • Open Access
16 Citations
5,739 Views
21 Pages

A Review of the Important Weapons against Antimicrobial Resistance in Sub-Saharan Africa

  • Noel Gahamanyi,
  • Therese Umuhoza,
  • Shamsaldeen Ibrahim Saeed,
  • Landry Ndriko Mayigane and
  • Jean Nepomuscene Hakizimana

Antimicrobial resistance (AMR) is one of the top 10 global health threats facing humanity, and the sub-Saharan Africa (SSA) is among the heavily affected regions due to its weak health systems and limited resources. Due to an escalating number of AMR...

  • Review
  • Open Access
8 Citations
5,651 Views
27 Pages

Lactiplantibacillus plantarum is omnipresent in vegetable fermentations. Its large metabolic capacity and its ability to adapt to the fermenting microenvironment enable this species, in many cases, to dominate the microecosystem and drive the ferment...

  • Review
  • Open Access
5,554 Views
13 Pages

Cancer pain is a highly prevalent problem and one of the most distressing symptoms in cancer patients. The management of cancer pain is one of the most significant challenges in the care of these patients. Cancer pain must be treated quickly and effe...

  • Article
  • Open Access
5 Citations
5,503 Views
22 Pages

17 August 2023

Rapid and accurate pathogen identification is crucial in effectively combating infectious diseases. However, the current diagnostic tools for bacterial infections predominantly rely on century-old culture-based methods. Furthermore, recent research h...

  • Article
  • Open Access
1 Citations
5,351 Views
17 Pages

Maximizing Common Bean (Phaseolus vulgaris L.) Productivity Through Application of Organic and Inorganic Fertilizers in Alkaline Soil

  • Safiullah Habibi,
  • Shafiqullah Aryan,
  • Ali Yawar Seerat,
  • Kalimullah Saighani and
  • Mohammad Daud Haidari

Common beans are a vital source of protein, vitamins, and minerals. Increasing common beans productivity is crucial for improving food security and farmers’ incomes globally. This study evaluated the growth and yield responses of common beans t...

  • Review
  • Open Access
15 Citations
5,340 Views
21 Pages

Multifunctional materials and devices with captivating properties can be assembled from cellulose and cellulose-based composite materials combining functionality with structural performance. Cellulose is one of the most abundant renewable materials w...

  • Article
  • Open Access
1 Citations
5,334 Views
15 Pages

A Flow Cytometry Protocol for Measurement of Plant Genome Size Using Frozen Material

  • Abhishek Soni,
  • Lena Constantin,
  • Agnelo Furtado and
  • Robert J Henry

Flow cytometry is widely applied to infer the ploidy and genome size (GS) of plant nuclei. The conventional approach of sample preparation, reliant on fresh plant material to release intact nuclei, often results in poor yields of nuclei in conditions...

  • Feature Paper
  • Review
  • Open Access
19 Citations
5,247 Views
17 Pages

Crossiella, a Rare Actinomycetota Genus, Abundant in the Environment

  • Tamara Martin-Pozas,
  • Jose Luis Gonzalez-Pimentel,
  • Valme Jurado,
  • Leonila Laiz,
  • Juan Carlos Cañaveras,
  • Angel Fernandez-Cortes,
  • Soledad Cuezva,
  • Sergio Sanchez-Moral and
  • Cesareo Saiz-Jimenez

The genus Crossiella contains two species, C. equi, causing nocardioform placentitis in horses, and C. cryophila, an environmental bacterium. Apart from C. equi, which is not discussed here, environmental Crossiella is rarely reported in the literatu...

  • Article
  • Open Access
5,204 Views
17 Pages

An Improved Approach to Protoplast Regeneration and Transfection in Banana (Musa acuminata AAA cv. Williams)

  • Pradeep Chand Deo,
  • Jean-Yves Paul,
  • Anthony James,
  • Rob Harding and
  • James Dale

Protoplasts offer a promising alternative to embryogenic cell suspensions (ECS) for gene editing in banana, potentially overcoming several limitations associated with ECS-based transformation systems. This study aimed to optimize protoplast isolation...

  • Article
  • Open Access
4 Citations
5,084 Views
21 Pages

Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus

  • Andrew Nelson,
  • Steven Voinier,
  • Jeremy Tran,
  • Kristin H. Gilchrist,
  • Melvin Helgeson,
  • Vincent B. Ho and
  • George J. Klarmann

6 February 2024

Torn and damaged menisci resulting from trauma are very common knee injuries, which can cause pain and mobility limitations and lead to osteoarthritis. Meniscal injuries can require surgery to repair the tissue damage and restore mobility. Here we de...

  • Article
  • Open Access
4,983 Views
12 Pages

Step-by-Step Development of a Recombinase Polymerase Amplification (RPA) Assay for Sex Identification in Papaya

  • José Guadalupe Ávila-Hernández,
  • Alejandro Coreño-Alonso,
  • Mario Alberto Pantoja-Alonso,
  • Francisco Javier Córdoba-Andrade,
  • Rogelio González-González,
  • Corina E. Díaz-Quezada,
  • Alberto Camas-Reyes and
  • Agustino Martínez-Antonio

24 September 2024

Papaya is a globally important crop, with production primarily based on hermaphrodite plants. Papaya has three sex types—male, female, and hermaphrodite—determined by flower morphology, but this is only distinguishable at the flowering st...

  • Review
  • Open Access
6 Citations
4,868 Views
20 Pages

Sustainable Pulse Proteins: Physical, Chemical and Fermentative Modifications

  • Seedhabadee Ganeshan,
  • Nancy Asen,
  • Yingxin Wang,
  • Mehmet Ç. Tülbek and
  • Michael T. Nickerson

Pulse proteins are playing significant roles in the alternative protein space due to the demand for foods produced in an environmentally sustainable manner and, most importantly, due to the demand for foods of nutritious value. There has been extensi...

  • Review
  • Open Access
6 Citations
4,780 Views
34 Pages

Can Caenorhabditis elegans Serve as a Reliable Model for Drug and Nutraceutical Discovery?

  • Opeyemi. O. Deji-Oloruntoba,
  • Taiwo. O. Elufioye,
  • Stephen Adeniyi Adefegha and
  • Miran Jang

Experimental research demands the selection of appropriate models to align with study objectives and conditions. Traditional experimental models, such as in vivo animal studies and in vitro systems like organoids, present nutraceutical and pharmaceut...

  • Review
  • Open Access
4 Citations
4,770 Views
16 Pages

29 April 2024

Growing demands for sustainable and ecological nanoparticle synthesis methods have incentivized the scientific community to develop new approaches to counteract these challenges. Green synthesis resorts to biocomponents obtained from plants, bacteria...

  • Article
  • Open Access
15 Citations
4,458 Views
19 Pages

The metabolic diversity of soil microbiota embodies diverse functional capabilities that support ecosystem resilience, driving essential biogeochemical processes and facilitating the optimization of sustainable agricultural systems. Integrating cover...

  • Article
  • Open Access
3 Citations
4,293 Views
14 Pages

19 September 2023

Bacterial contamination of water and food sources is still a major source of diseases. Early detection of potential pathogens is key to prevent their spreading and severe health risks. Here, we describe a fast, low-cost detection assay based on horse...

  • Review
  • Open Access
9 Citations
4,227 Views
14 Pages

Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles

  • Renata F. Saito,
  • Camila Maria Longo Machado,
  • Ana Luiza Oliveira Lomba,
  • Andréia Hanada Otake and
  • Maria Cristina Rangel

From an evolutive perspective, tumor cells endure successive turnover upon stress conditions and pressure to adapt to new environments. These cells use exceptional communication skills to share biological information to “survive upon every meta...

  • Article
  • Open Access
4 Citations
4,187 Views
15 Pages

Digital Pathology and Ensemble Deep Learning for Kidney Cancer Diagnosis: Dartmouth Kidney Cancer Histology Dataset

  • Muskan Naresh Jain,
  • Salah Mohammed Awad Al-Heejawi,
  • Jamil R. Azzi and
  • Saeed Amal

Kidney cancer has become a major global health issue over time, showing how early detection can play a very important role in mediating the disease. Traditional histological image analysis is recognized as the clinical gold standard for diagnosis, al...

  • Article
  • Open Access
6 Citations
4,154 Views
16 Pages

1 September 2023

The interest in under-utilized crops as a functional food for animals and humans has been increasing recently with advancing research and the need for crop improvement. Canadian forage crops including alfalfa (Medicago sativa L.) and fenugreek (Trigo...

  • Review
  • Open Access
3 Citations
4,105 Views
13 Pages

Urinary Markers for Prostate Cancer: State of the Art

  • Carlo Giorgio Costi,
  • Serena Sartori,
  • Riccardo Danuso,
  • Andrea Piasentin,
  • Paolo Umari and
  • Giovanni Liguori

Prostate cancer (PCa) is one of the most common malignancies in men, where early and accurate detection is crucial. While PSA testing has been the diagnostic standard, its limited specificity leads to unnecessary biopsies and missed significant cance...

  • Review
  • Open Access
8 Citations
4,105 Views
16 Pages

Over the last ten years, with the progress of in vitro culture methods, it has been possible to build increasingly reliable models to effectively mimic in vivo ones. The translational methodological approach that combined biotechnology and biomedical...

  • Article
  • Open Access
4,014 Views
13 Pages

Direct Expression of CPT1a Enables a High Throughput Platform for the Discovery of CPT1a Modulators

  • Jason Chen,
  • Tuyen Tran,
  • Anthony Wong,
  • Luofei Wang,
  • Pranavi Annaluru,
  • Vibha Sreekanth,
  • Samika Murthy,
  • Laasya Munjeti,
  • Tanya Park and
  • Zhan Chen
  • + 13 authors

Carnitine palmitoyltransferase 1 (CPT1), which catalyzes the rate-limiting step of fatty acid oxidation, has been implicated in therapeutic approaches to several human diseases characterized by aberrant lipid metabolism. The isoform-specific quantifi...

  • Article
  • Open Access
1 Citations
3,932 Views
14 Pages

Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease?

  • Priscila Nogueira Bezan,
  • Héric Holland,
  • Bárbara Ferreira Vercesi,
  • Paula Payão Ovídio,
  • Livia Maria Cordeiro Simões and
  • Alceu Afonso Jordão

Background and objectives: Carbohydrates such as fructooligosaccharides (FOSs) are associated with improved gastrointestinal health and the prevention of excess body fat. We evaluated the long-term effects of high amounts of FOS on metabolic paramete...

  • Review
  • Open Access
3 Citations
3,799 Views
17 Pages

Tuning Up In Vitro Growth and Development of Cannabis sativa: Recent Advances in Micropropagational Approach

  • S. M. Ahsan,
  • Md. Injamum-Ul-Hoque,
  • Ashim Kumar Das,
  • Shifa Shaffique,
  • Mehedi Hasan,
  • Sang-Mo Kang,
  • In-Jung Lee and
  • Hyong Woo Choi

Cannabis sativa is used for multiple purposes, notably for its medicinal properties. It produces various secondary metabolites, including cannabinoids, terpenes, and flavonoids, which have therapeutic value and typically produce high amounts in femal...

  • Article
  • Open Access
3 Citations
3,774 Views
21 Pages

Central nervous system (CNS) white matter pathologies accompany many diseases across the lifespan, yet their biochemical bases, mechanisms, and consequences have remained poorly understood due to the complexity of myelin lipid-based research. However...

  • Article
  • Open Access
5 Citations
3,691 Views
13 Pages

Chitinases are biotechnologically relevant enzymes that can be applied in such different sectors as pharmaceutical, food, environmental management, the biocontrol of pests and in the paper and cellulose industry. Microorganisms as filamentous fungi a...

  • Review
  • Open Access
8 Citations
3,670 Views
22 Pages

Nanobiotechnology in Bone Tissue Engineering Applications: Recent Advances and Future Perspectives

  • Neelam Iqbal,
  • Tejal Pant,
  • Nanda Rohra,
  • Abhishek Goyal,
  • Merin Lawrence,
  • Anomitra Dey and
  • Payal Ganguly

15 November 2023

Bone regeneration and repair are complex processes with the potential of added complications, like delayed repair, fracture non-union, and post-surgical infections. These conditions remain a challenge globally, pressurizing the economy and patients s...

  • Article
  • Open Access
1 Citations
3,654 Views
13 Pages

Cardiac contractile cells depend on calcium in order to function. Understanding the regulation of calcium influx, efflux, and release from the sarcoplasmic reticulum is essential. The focus of this investigation is to address how a reduction of funct...

  • Review
  • Open Access
4 Citations
3,602 Views
14 Pages

As isobutanol exhibits higher energy density and lower hygroscopicity than ethanol, it is considered a better candidate biofuel. The sustainable supply of inedible biomass and lack of competition with the food supply have stimulated significant world...

  • Article
  • Open Access
3,559 Views
14 Pages

Toothpaste is an essential oral hygiene product commonly used to sustain oral health due to its incorporation of antimicrobial agents. Numerous functional toothpastes enriched with antimicrobial agents have been developed and are available to consume...

  • Article
  • Open Access
2 Citations
3,500 Views
18 Pages

Multi-Criteria Decision Analysis in Drug Discovery

  • Rafał A. Bachorz,
  • Michael S. Lawless,
  • David W. Miller and
  • Jeremy O. Jones

Drug discovery is inherently a multi-criteria optimization problem. In the first instance, it involves a tremendously large chemical space, where each compound can be characterized by multiple molecular and biological properties. Modern computational...

  • Article
  • Open Access
3,477 Views
16 Pages

4 August 2023

As schools go digital, the use of tablet computers is increasing. Concerns are raised that the extensive use of tablets and the associated bent-over posture may negatively affect the individual’s health. In order to analyse the possible effects...

  • Article
  • Open Access
2 Citations
3,420 Views
13 Pages

A Single Dose of Microencapsulated Cocoa Supplementation Does Not Speed up Muscle Force Recovery after Eccentric Exercise-Induced Muscle Damage: A Placebo-Controlled, Double-Blind, Crossover Study

  • Olavo João Frederico Ramos Junior,
  • Karen Souza dos Santos,
  • Isabela Ribeiro Grangeira Tavares,
  • Gustavo Vieira de Oliveira and
  • Thiago Silveira Alvares

22 December 2023

Exercise-induced muscle damage is associated with symptoms such as inflammation, delayed-onset muscle soreness, and impaired muscle performance. The intake of cocoa polyphenols has been suggested to improve muscle recovery due to their antioxidant an...

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Appl. Biosci. - ISSN 2813-0464