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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics and Antimicrobial Resistance in Pathogens of Hospital Importance

edited by

Maria de Lourdes R.S. Cunha

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1663 | Submission Open

Keywords: ESKAPEE pathogens; antimicrobial resistance; multidrug-resistant organisms; genetics; resistance mechanisms

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Antimicrobial Properties of Essential Oils: Activities, Mechanisms, Applications, and Therapeutic Potential

edited by

Eduardo Valarezo

Miguel Ángel Meneses

and Matteo Radice

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1425 | Submission Open

Keywords: antibiotics; antibacterial; antifungal; antiviral; ethnopharmacology; multidrug resistance; natural products; resistant strains; volatile secondary metabolites; volatile compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Structure and Function of Antimicrobial Peptides

edited by Daniel Balleza and

Gill Diamond

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1054 | Submission Open

Keywords: antimicrobial peptides; natural peptides; lipidomics; synergistic action; bioactivity mechanisms; structure reconfiguration

(This special issue belongs to the Section Antimicrobial Peptides)

Fungal Metabolites and Synthetic Derivatives: Antimicrobial Properties Toward Microbial Pathogens

edited by

João Vicente Braga De Souza

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1025 | Submission Open

Keywords: antimicrobial resistance; fungal metabolites; synthetic derivatives; antifungal agents; bioactive compounds

(This special issue belongs to the Section Fungi and Their Metabolites)

ESKAPE and MDRO Pathogens: Infections and Antimicrobial Treatment

edited by

Carlo Pallotto

submission deadline 31 Oct 2025 | 1 articles | Viewed by 961 | Submission Open

Keywords: ESKAPE; MDRO; Escherichia coli; Staphylococcus aureus; Klebsiella pneumoniae; Acinetobacter baumannii; Pseudomonas aeruginosa; Enterococcus faecalis; Enterococcus faecium; Stenotrophomonas maltophilia; Enterobacter cloacae; antimicrobial stewardship

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotics in the Environment: Sources, Fate, and Mitigation Strategies

edited by Khaled Benis

submission deadline 31 Oct 2025 | 1 articles | Viewed by 926 | Submission Open

Keywords: antibiotic contamination; environmental fate; antibiotic resistance; mitigation strategies; pollution management

Environmental Fate and Effects of Antibiotics and Antibiotic Resistance Genes, 2nd Edition

edited by

Anna Barra Caracciolo

and Ludovica Rolando

submission deadline 31 Oct 2025 | 1 articles | Viewed by 882 | Submission Open

Keywords: antibiotic-resistant bacteria; antibiotic resistance genes; environmental spread; bioaccumulation; biodegradation; antibiotic mixture

Epidemiology and Treatment of Microbial Infections in Respiratory Diseases

edited by

Marija Vukoja

and

Peđa Kovačević

submission deadline 31 Oct 2025 | 1 articles | Viewed by 763 | Submission Open

Keywords: pulmonary infections; respiratory diseases; epidemiology; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Novel Antimicrobial Strategies to Combat Multidrug-Resistant (MDR) Gram-Negative Bacteria, 2nd Edition

edited by

Valerie Carabetta

submission deadline 31 Oct 2025 | 1 articles | Viewed by 662 | Submission Open

Keywords: gram negative; antibiotic resistance; antiseptic resistance; multidrug resistant; extensively drug resistant; pandrug resistant; MDR; XDR; PDR; efflux pumps; mechanisms of resistance; beta-lactamase; outer membrane

Essential Oils as Natural Antimicrobials: Extraction, Characterization, and Synergistic Applications

edited by

Sergio A. Rodríguez

, Axel Hollmann and

Douglas Siqueira de Almeida Chaves

submission deadline 31 Oct 2025 | 1 articles | Viewed by 570 | Submission Open

Keywords: natural antimicrobials; biofilm eradication; mechanism of action; synergism; antagonism; cytotoxicity; compound isolation; membrane interaction; enzymatic inhibition; DNA interaction; oxidative stress

(This special issue belongs to the Section Plant-Derived Antibiotics)

Etiology, Clinical Presentation, Antibiotic and Surgical Treatment of Infective Endocarditis

edited by Francesco Santini,

Francesco Onorati

and

Antonio Salsano

submission deadline 31 Oct 2025 | Viewed by 549 | Submission Open

Keywords: infective endocarditis; acute; bacterial; diagnosis; treatment; valvular heart disease; cardiac surgery; cardiac prosthesis; complications; intensive care

Pathogenesis, Epidemiology and Antibiotic Resistance of Salmonella

edited by

Angela Pista

and

Leonor Silveira

submission deadline 31 Oct 2025 | Viewed by 399 | Submission Open

Keywords: Salmonella; epidemiology; genomics; public health; antimicrobial resistance; One-Health approach

Combating Antimicrobial Resistance Spread in Food and Drinks Using Bacteriophage Technologies

edited by

Janet Nale

submission deadline 31 Oct 2025 | Viewed by 184 | Submission Open

Keywords: bacteriophage; phage therapy; antimicrobial resistance; food; drink; water; agriculture; pathogenic bacteria; lytic phages; lysogens; prophages; temperate phage

(This special issue belongs to the Section Bacteriophages)

Antimicrobial Activity of Natural Products and Plants Extracts, 2nd Edition

edited by

Mihaela Niculae

and

Daniela Hanganu

submission deadline 31 Oct 2025 | Viewed by 166 | Submission Open

Keywords: natural products; plant extracts; bioactive compounds; phytoconstituents; antibacterial efficacy; in vitro screening; in vivo evaluation; antibiofilm; anti-quorum

(This special issue belongs to the Section Plant-Derived Antibiotics)

Prevalence, Treatment and Antibacterial Resistance of Urinary Tract Infections

edited by Alin Gabriel Mihu and

Tudor Rares Olariu

submission deadline 31 Oct 2025 | Viewed by 127 | Submission Open

Keywords: urinary tract infections; UTI; antibiotic; antibacterial; resistance; uropathogens; recurrent UTI; Enterobacteriaceae; Escherichia coli

Antimicrobial Resistance, Epidemiology, Clinical Impact and Molecular Characterization of Multidrug-Resistant ESKAPEE Pathogens

edited by

Lorenzo Pace

and Viviana Manzulli

submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open

Keywords: ESKAPEE; antimicrobial resistance; antibiotic resistance; multidrug-resistant pathogens; nosocomial infection; molecular mechanism

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures, 2nd Edition

edited by

Angel-Orion Salgado-Peralvo

and

Eugenio Velasco-Ortega

submission deadline 31 Oct 2025 | Viewed by 100 | Submission Open

Keywords: antibiotics; preventive antibiotic therapy; antibiotic prophylaxis; bacterial antibiotic resistance; antibiotic resistance; oral implantology; dental implantology; dental implants; dentistry; oral surgery

Novel Preventive and Therapeutic Strategies to Eradicate Biofilm Infections Based on New Antibacterial Compounds

edited by

María Guembe

submission deadline 31 Oct 2025 | Viewed by 98 | Submission Open

Keywords: antibacterial; biofilm; infection; innovation; microbiota

(This special issue belongs to the Section Antibiofilm Strategies)

Metal-Based Antibiotics and Therapeutics

edited by

Sotiris K Hadjikakou

and

Christina N. Banti

submission deadline 31 Oct 2025 | Viewed by 84 | Submission Open

Keywords: biological inorganic chemistry; metallotherapeutics; metal-based antibiotics; antimicrobial compounds; antimicrobial resistance (AMR); antimicrobials materials or nanoparticles; active medical devices

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Properties of Natural Substances: Alternatives for Managing Microbial Contamination

edited by

Bojana Danilović

and

Ivana Karabegović

submission deadline 31 Oct 2025 | Viewed by 76 | Submission Open

Keywords: antimicrobial activity; microbial contamination; essential oils; plant extracts

(This special issue belongs to the Section Plant-Derived Antibiotics)

Biotechnological Production of Novel Antimicrobials

edited by

Vanja Vlajkov

Jovana Grahovac

and

Ivana Danilov

submission deadline 1 Nov 2025 | 1 articles | Viewed by 837 | Submission Open

Keywords: antibiotic resistance; biotechnology; antimicrobial activity; disease outbreak; pathogens; microorganisms; genetic engineering; artificial intelligence; optimisation; biocontrol

A Themed Issue in Honor of Professor Helen Giamarellou—Outstanding Contributions in the Fields of Antimicrobial Resistance and Difficult-to-Treat Resistance Pathogens

edited by Konstantinos Pontikis

submission deadline 5 Nov 2025 | 5 articles | Viewed by 8268 | Submission Open

Keywords: antibiotic stewardship; nosocomial infections; infection control; epidemiology of resistance plus in vitro investigation of underlying resistance mechanisms; infections in the ICU; neutropenic host infections; indicated therapeutic approach of MDR and XDR gram-negative infections; pharmacokinetics/pharmacodynamics of newer antimicrobial agents

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

New Natural Products as Candidates for the Discovery of Antimicrobial Drugs

edited by

Maya Zaharieva

and

Hristo Najdenski

submission deadline 15 Nov 2025 | 5 articles | Viewed by 14693 | Submission Open

Keywords: natural products; antimicrobial mechanisms and strategies; combination effects; clinical applicability; in silico; in vitro and in vivo models; infection control

(This special issue belongs to the Section Plant-Derived Antibiotics)

Pathogenic Microorganisms and Antibiotic Therapy in Infectious Disease

edited by

Angela Quirino

Grazia Pavia

and

Nadia Marascio

submission deadline 15 Nov 2025 | 2 articles | Viewed by 4717 | Submission Open

Keywords: antimicrobial resistance; pathogenic mechanisms; multidrug-resistant microorganisms; antimicrobial drugs; innovative therapeutic strategies

The Battle Against Urinary Tract Infections: The Role of Antibiotics

edited by

Pawel Miotla

and

Sara Wawrysiuk

submission deadline 15 Nov 2025 | 1 articles | Viewed by 1631 | Submission Open

Keywords: urinary tract infection (UTI); antibiotics; antimicrobial resistance (AMR); multidrug-resistant uropathogens; antibiotic stewardship; UTI treatment; novel antibiotics; phage therapy; UTI pathogenesis; probiotics in UTI management

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Resistance in Aquaculture: Balancing Health and Sustainability

edited by

Zhigang Zhou

submission deadline 15 Nov 2025 | Viewed by 76 | Submission Open

Keywords: antimicrobial resistance; aquaculture; one health approach; antibiotic stewardship; probiotics; zoonotic pathogens; resistance genes; sustainable practices; environmental impact

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Biomaterials for Dentistry

edited by

Edith Lara-Carrillo

submission deadline 18 Nov 2025 | Viewed by 120 | Submission Open

Keywords: antimicrobials; dentistry; microorganisms; biomaterials; caries risk; oral environment; epidemiology

Environmental Fate of Antibiotics: Monitoring, Toxicity, Resistance, and Removal Methods

edited by

Takashi Azuma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11455 | Submission Open

Keywords: antimicrobials; high-throughput analysis; wastewater treatment plant (WWTP); hospital wastewater; livestock environment; water purification plant (WTP); aquatic environment; environmental health risk assessment; antimicrobial resistance (AMR); advanced water treatment

Bioactive Peptides and Their Antibiotic Activity

edited by

Hamilton Cabral

submission deadline 30 Nov 2025 | 7 articles | Viewed by 10568 | Submission Open

Keywords: database peptides; therapeutic agents; peptide design; antimicrobial peptides; antibiotic resistance; therapeutic drugs

(This special issue belongs to the Section Antimicrobial Peptides)

Antibiotic Resistance and Virulence Mechanisms in Gram-Negative Bacteria: An Alliance for Success

edited by

Francesco Imperi

submission deadline 30 Nov 2025 | 6 articles | Viewed by 7454 | Submission Open

Keywords: virulence; Gram-negative; antimicrobial resistance; One Health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Comprehensively Addressing Antimicrobial Resistance, Improving Food Safety and Achieving the One Health Goals: Global Challenges

edited by

Vladimir Kurćubić

, Pavle Mašković,

Milan N. Mitić

and

Nikola Stanišić

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4874 | Submission Open

Keywords: antimicrobial resistance (AMR); food safety; foodborne pathogens; antibiotic residues; natural antimicrobials; one health

Antibiotic and Antiparasitic Resistance in Veterinary Clinical Settings

edited by

Daphne Lianou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3835 | Submission Open

Keywords: animal; cattle; cat; dog; goat; horse; pig; poultry; sheep; therapeutics; treatment; veterinary; wildlife

(This special issue belongs to the Section Antibiotics in Animal Health)

Spread of Multidrug-Resistant Microorganisms, 2nd Edition

edited by

Mara Di Giulio

and

Silvia Di Lodovico

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3338 | Submission Open

Keywords: multidrug-resistant organisms; MDR; antibiotic resistance gene; nosocomial infections; new marker of resistance

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Patients

edited by Young Ran Lee

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3189 | Submission Open

Keywords: therapeutic drug monitoring (TDM); antibiotics; antimicrobials; pharmacokinetic; pharmacodynamic; critically ill

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3183 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

Innovations in Plant-Based Antibiotic and Antiviral Agents

edited by

Margherita-Gabriella De Biasi

and

Irene Dini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2467 | Submission Open

Keywords: secondary metabolites; phytochemicals; botanicals; analytical methods; toxicity

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Susceptibility of Veterinary Origin Bacteria

edited by Luchao Lv and Jing Wang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1841 | Submission Open

Keywords: antimicrobial resistance; animal-derived resistant; antimicrobial-resistant bacteria; foodborne pathogens

(This special issue belongs to the Section Antibiotics in Animal Health)

Pharmacokinetics and Pharmacodynamics of Antibacterial and Antivirulence Drugs, 2nd Edition

edited by

Takahisa Yano

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1342 | Submission Open

Keywords: pharmacokinetics; pharmacodynamics; clinical trials; antimicrobial resistance; antibacterials; antivirulence drugs; pathoblockers; antimicrobial use; drug utilization studies; PK/PD modeling; PBPK-modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1279 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Antibiotic Stewardship and Infection Control Strategies in Critical Care

edited by

Susana M. Fernandes

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1199 | Submission Open

Keywords: infection prevention; critical care; sepsis; stewardship practices

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Discovery of Novel Antimicrobial Agents to Combat Infections

edited by

Yuanpu Peter Di

submission deadline 30 Nov 2025 | 1 articles | Viewed by 454 | Submission Open

Keywords: antimicrobials; resistance; bacteriophage; virulence; structure; PD/PK; bacteria; virus; fungus

(This special issue belongs to the Section Novel Antimicrobial Agents)

A Themed Issue in Honor of Dr. Lynne V. McFarland—Clostridioides difficile Infection and Impact of Antibiotics on the Intestinal Microbiome

edited by Ellie J. C. Goldstein and Shan Goh

submission deadline 30 Nov 2025 | Viewed by 353 | Submission Open

Keywords: Clostridioides difficile infections; intestinal microbiome; infection control practices; antibiotic complications; probiotics; live biotherapeutic products; treatment; prevention

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Resistance and Evolving Biology in Mycobacteria: Multidisciplinarity as a Contemporary Approach

edited by

Irena Arandjelovic

and Dragana Vukovic

submission deadline 30 Nov 2025 | Viewed by 315 | Submission Open

Keywords: tuberculosis; drug resistance; evolutionary biology; pathogen-host interactions

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Drug Discovery in the Fight Against Bacterial Infections

edited by

Sara M. Soto

and

Raquel G. Soengas

submission deadline 30 Nov 2025 | Viewed by 216 | Submission Open

Keywords: drug discovery against gram-positive bacteria; drug discovery against gram-negative bacteria; drug discovery against fungi; drug discovery against biofilms

Novel Approaches to Prevent and Combat Antimicrobial Resistance

edited by

Xiaotao Jiang

submission deadline 30 Nov 2025 | Viewed by 183 | Submission Open

Keywords: antimicrobial peptides; novel antibiotics screening; phage therapy; fecal microbiota transplantation (FMT); dietary and functional food interventions; AMR prevention strategies

Mastitis: Causative Agents, Drug Resistance, and Treatment Approaches—2nd Edition

edited by

Amira A. Moawad

Hosny El-Adawy

and Heinrich Neubauer

submission deadline 30 Nov 2025 | Viewed by 135 | Submission Open

Keywords: mastitis; etiology; multi-drug resistance; alternative bovine mastitis treatment; WGS

(This special issue belongs to the Section Antibiotics in Animal Health)

Neonatal Infection: Antibiotics for Prevention and Treatment

edited by Cinzia Auriti and Maria Paola Ronchetti

submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open

Keywords: neonatal infections; neonatal sepsis; sepsis definition; antibiotics in newborns; antibiotic stewardship; sepsis biomarkers; sepsis diagnosis in newborns; epidemiology of neonatal infections; fungal invasive infections

Animal-Origin Bacteria: Diversity, Pathogenicity and Antimicrobial Resistance

edited by

Juliana Menezes

Joana Moreira da Silva

and

Adriana Belas

submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open

Keywords: AMR; virulence; bacteria; zoonosis; companion animals; alternative therapy; food-producing animals; exotic animals; wildlife; One Health

Antimicrobial Agents for Drug-Resistant Infections: From Identification to Preclinical and Clinical Trials

edited by

Javier Eduardo García Castañeda

and

Zuly Jenny Rivera-Monroy

submission deadline 30 Nov 2025 | Viewed by 96 | Submission Open

Keywords: antimicrobials agents; drug resistant; anti-cancerogenic agents; drug development; preclinical trials; clinical trials; pharmaceutical optimization

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial and Anti-Inflammatory Activity of Bioactive Compounds Extracted from Plants, 2nd Edition

edited by