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Antibiotics
Special Issues
Antimicrobial Biomaterials for Dentistry
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Antimicrobial Biomaterials for Dentistry

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 2342

Special Issue Editor

Prof. Dr. Edith Lara-Carrillo

E-Mail Website
Guest Editor
Center for Research and Advanced Studies in Dentistry, School of Dentistry, Autonomous University of Mexico State, Toluca, Estado de México, Mexico
Interests: caries risk; biomaterials; oral environment; epidemiology; orthodontics

Special Issue Information

Dear Colleagues,

The oral cavity microbiome is a very complex system that requires balance for its health; therefore, combating microorganisms that disrupt this ecosystem is essential. Current dental practice has focused on addressing the causative agents of the various diseases and conditions that can occur in the oral cavity.

Dentistry has currently shifted toward the identification, creation, and application of various biomaterials with antimicrobial action that help regulate the oral environment.

This Special Issue focuses on educating dentists, physicians, hygienists, and all professionals involved in human health about new technologies and their application in one of the medical areas that has turned its attention to disease prevention across a variety of specialties, not just restoration.

Prof. Dr. Edith Lara-Carrillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobials
  • dentistry
  • microorganisms
  • biomaterials
  • caries risk
  • oral environment
  • epidemiology

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Published Papers (2 papers)

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Research

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15 pages, 829 KB  
Article
In Vitro Antimicrobial Potential of Different Platelet Concentrates Against Eight Clinically Relevant Oral Pathobionts
by Ellen E. Jansen, Zahra Hejazi, Andreas Braun, Patrick Jansen and Georg Conrads
Antibiotics 2026, 15(2), 173; https://doi.org/10.3390/antibiotics15020173 - 5 Feb 2026
Viewed by 754
Abstract
Background/Objectives: Oral infections are caused by a wide spectrum of bacterial and fungal species and remain clinically challenging, particularly against the background of increasing antimicrobial resistance and efforts to reduce antibiotic use in dentistry. Platelet concentrates are widely applied in periodontal and oral [...] Read more.
Background/Objectives: Oral infections are caused by a wide spectrum of bacterial and fungal species and remain clinically challenging, particularly against the background of increasing antimicrobial resistance and efforts to reduce antibiotic use in dentistry. Platelet concentrates are widely applied in periodontal and oral surgery due to their regenerative and immunomodulatory properties, and accumulating evidence suggests additional antimicrobial effects. This study evaluated the antimicrobial activity of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and injectable PRF (i-PRF) against clinically relevant oral microorganisms. Methods: PRP, PRF, and i-PRF were prepared from venous blood of five healthy donors and evaluated using diffusion-dependent, qualitative-semiquantitative agar diffusion assays against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Staphylococcus aureus, Streptococcus mutans, Streptococcus mitis, Enterococcus faecalis, and Candida albicans, with inhibition zones assessed after species-specific incubation times. Chlorhexidine (2%) and amoxicillin served as positive controls and NaCl (0.9%) as negative control. Inhibition zones were digitally quantified and analyzed using non-parametric statistics (Kruskal–Wallis, Friedmann) due to skewed distributions and frequent zero values. Results: All platelet concentrates demonstrated microorganism-dependent inhibition zones in vitro. Overall, i-PRF demonstrated the strongest inhibitory effect across all pathogens (p < 0.001). Significant differences were detected for E. faecalis and C. albicans, where i-PRF produced markedly larger inhibition zones compared to PRP and PRF. Descriptively, anaerobic periodontal pathogens and S. aureus tended to be more susceptible, while streptococci and C. albicans demonstrated lower inhibition. Conclusions: These findings support a potential adjunctive antimicrobial role of platelet-derived preparations in dental infection management but should be interpreted with caution, as agar diffusion results do not necessarily reflect clinical performance. Full article
(This article belongs to the Special Issue Antimicrobial Biomaterials for Dentistry)
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Review

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18 pages, 646 KB  
Review
Silver Nanoparticles Used in Medical–Dental Plastics for Therapeutic Purposes: A Comprehensive Review
by José Luis Maruri-Casas, Edith Lara-Carrillo, Víctor Hugo Toral-Rizo, Raúl Alberto Morales-Luckie, Gloria Elena Guzmán-Celaya, Norma Guadalupe Ibañez-Mancera, Francisco Javier Tejeda-Nava, Saraí Carmina Guadarrama-Reyes, Elías Nahúm Salmerón-Valdés and Ana Miriam Santillán-Reyes
Antibiotics 2025, 14(12), 1267; https://doi.org/10.3390/antibiotics14121267 - 15 Dec 2025
Cited by 1 | Viewed by 997
Abstract
Background/Objectives: The integration of silver nanoparticles (AgNPs) into plastic materials has emerged as a promising strategy to provide biomedical and dental devices with an active antimicrobial barrier. In this review, we aimed to synthesize the scientific evidence published between 2013 and 2024 regarding [...] Read more.
Background/Objectives: The integration of silver nanoparticles (AgNPs) into plastic materials has emerged as a promising strategy to provide biomedical and dental devices with an active antimicrobial barrier. In this review, we aimed to synthesize the scientific evidence published between 2013 and 2024 regarding the therapeutic efficacy, biocompatibility, and safety of AgNP-functionalized plastics by following the 2020 PRISMA guidelines. Methods: Searches were conducted in PubMed, Scopus, Web of Science, SciELO, and ScienceDirect. A total of 634 records were identified, of which 21 studies met the inclusion criteria after full-text evaluation. Results: Plastics containing AgNPs show a significant reduction in microbial load (Escherichia coli, Stafilococcus aureus, and Candida albicans) and exhibit controlled release of Ag+ ions, with generally low cytotoxicity levels. The most frequent applications included catheters, dental prostheses, dressings, and orthodontic resins. However, methodological heterogeneity and the scarcity of clinical trials limit the extrapolation of findings. Conclusions: AgNPs confer relevant therapeutic advantages to polymers, but long-term clinical studies are needed to confirm their safety and effectiveness. Full article
(This article belongs to the Special Issue Antimicrobial Biomaterials for Dentistry)
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