Fungal Metabolites and Synthetic Derivatives: Antimicrobial Properties Toward Microbial Pathogens
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Fungi and Their Metabolites".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 1018
Special Issue Editor
Special Issue Information
Dear Colleagues,
The resistance of bacteria to current antibiotics and the limitations in toxicity of antiparasitic and antifungal medications pose significant challenges to global public health. Fungal metabolites and their synthetic derivatives have long been explored as promising alternatives, with notable successes such as penicillins and cephalosporins. Additionally, key antifungal agents (including griseofulvin and echinocandins) originating from fungal sources highlight the importance of these natural products in antimicrobial therapy. Synthetic derivatives of natural products, such as β-lactams, including carbapenems, are crucial in treating resistant bacterial infections. Furthermore, the development of synthetic triazole derivatives has enhanced antifungal therapy, providing broader-spectrum activity and better pharmacokinetic properties. These compounds exemplify the potential of synthetic modifications to enhance efficacy and reduce toxicity.
This Special Issue aims to explore the antimicrobial properties of fungal metabolites and their synthetic derivatives, focusing on innovative approaches to combat microbial pathogens. We invite contributions that delve into the discovery, development, and application of these compounds, as well as their underlying mechanisms of action.
We encourage researchers worldwide to submit original research articles and reviews related to fungal metabolites and synthetic derivatives. Moreover, this Special Issue is proudly edited by João Vicente Braga de Souza, one of the Amazonian researchers dedicated to exploring the unparalleled fungal biodiversity of the Amazon in search of new antimicrobial agents.
Potential themes include the identification of novel fungal metabolites, synthetic modifications of natural products, and case studies of successful antimicrobial applications. Original research and reviews are welcome.
We look forward to your contributions to this Special Issue, which symbolizes a collective effort to discover the next generation of antibiotics.
Prof. Dr. João Vicente Braga De Souza
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antimicrobial resistance
- fungal metabolites
- synthetic derivatives
- antifungal agents
- bioactive compounds
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
