Biotechnological Production of Novel Antimicrobials
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 1 November 2025 | Viewed by 521
Special Issue Editors
Interests: biochemical engineering; biocontrol; environmental biotechnology; industrial microbiology; molecular microbiology; bioprocess engineering
Interests: biochemical engineering; microbial biomass; biofuels; bioactive compounds; bioprocess engineering; waste management
Special Issue Information
Dear Colleagues,
The emergence of highly resistant bacteria in clinical, agricultural, and environmental settings presents the leading risk of the 21st century, threatening the global economy and public health. Immediate action in terms of the development of novel antimicrobials as efficient tools in fighting microbes is one of the leading tasks for scientists in the era of antimicrobial resistance. The evolution and spread of novel antibiotic-resistant bacteria are likely to cause the next global pandemic after COVID-19, with estimated mortality rates leading to even 10 million human deaths per annum by 2050. Bacterial strains are constantly evolving mechanisms to combat even last-resort antibiotics, challenging our capacities to find suitable solutions to confront them. In the context of finding answers for this antibiotic crisis, particular focus is given to research relying on biotechnological approaches as powerful techniques for generating compounds with antimicrobial activity. Genetic engineering methods and modifications made on a molecular level are some of the first choices, traditionally employed using bacteria, yeast, and mammalian cells for recombinant protein production. In recent years, additional attention has been given to plant expression systems, as well as the application of artificial intelligence for novel chemotype screening. Potent antibiotic producers exist in highly competitive environments, such as plant rhizospheres, biological soil crusts, deep sea hydrothermal vents, marine snow, modern plastispheres; microbial habitants’ battle for survival is based on competitive interactions with other organisms present in the ecosystem.
The Special Issue of Antibiotics encourages the submission of original research papers, short communications, reviews, case reports, and perspectives that will enable a better understanding of various aspects of this topic. It aims to highlight the current state of and future perspectives on the most important questions affecting the future of antimicrobial compound production, including but not limited to the following: producing microorganisms isolation and seletion, genetic modifications and analysis, production parameters definition, the selection of bio-based raw materials, and methods for antimicrobial compounds extraction.
Dr. Vanja Vlajkov
Prof. Dr. Jovana Grahovac
Dr. Ivana Danilov
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antibiotic resistance
- biotechnology
- antimicrobial activity
- disease outbreak
- pathogens
- microorganisms
- genetic engineering
- artificial intelligence
- optimisation
- biocontrol
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