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Special Issue "Bioactive Peptides and Their Antibiotic Activity"
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".
Deadline for manuscript submissions: 31 December 2023 | Viewed by 900
Special Issue Editor
Interests: bioactive peptides; cancer; natural peptides; molecular biology; proteases and proteomic
Special Issues, Collections and Topics in MDPI journals
Special Issue in Biomolecules: Peptides: Molecular and Biotechnological Aspects Volume 2
Special Issue Information
The polypeptide chains of peptides with antimicrobial activity generally have fifty or fewer amino acid residues. Depending on the composition of the amino acids that make up the polypeptide chain, antimicrobial peptides can have cationic, anionic, and/or aromatic charged in addition to their characteristic size and conformation. . Antimicrobial peptides (AMPs) are conserved biomolecules, and are part of the defense systems of many organisms, from prokaryotes to multicellular organisms such as humans . AMPs are produced by organisms as a defense mechanism against pathogenic microbes. Initial studies on defense peptides identified defensins, cecropins, retropins and cathelicidins, which have different structures and bioactivities . Antimicrobial peptides can be classified according to their source (animal, plant, microbial, insect, amphibian, aquatic), and by their structure (α-helix, β-sheet, both α-helix and β-sheet, linear). They are also classified based on species rich in amino acids (especially Gly, Arg, Pro, His and Trp), and depending on their activity (e.g., antimicrobial, antiviral, antiparasitic, antifungal, anti-inflammatory and anticancer) . The first reported AMP was gramicidin, isolated from Bacillus brevis in 1939. Defensin, another AMP, was isolated from rabbit leukocytes. Since the 1960s, there has been a great interest in these peptides, and more than 5000 AMPs have been reported . Thus, peptides are considered promising molecules not only for application as antimicrobial therapy, but also in immunomodulatory, anticancer, antioxidant and other applications . Currently, many in silico analysis methods have been helping to target peptides for antimicrobial applications. Molecular biology techniques associated with bioinformatics are also providing good results in obtaining more effective AMPs.
 Cardoso, P., Glossop, H., Meikle, T. G., Aburto-Medina, A., Conn, C. E., Sarojini, V., Valery, C. Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities. Biophysical Reviews, 2021, vol. 13, p.35–69, https://doi.org/10.1007/s12551-021-00784-y.
 Ebenhan, T., Gheysens, O., Kruger, H. G., Zeevaart, J. R., Sathekge, M. M. Antimicrobial peptides: their role as infection-selective tracers for molecular imaging. Biomed Research International, 2014, Article ID, 867381, p.1-15. https://doi.org/10.1155/2014/867381.
 Fjell, C. D., Hiss, J. A., Hancock, R. E. W., Schneider, G. Designing antimicrobial peptides: form follows function. Nature Reviews Drug Discovery, Vol. 11, January 2012, p.37-51. https://doi.org/10.1038/nrd3591.
 Huan, Y., Kong, Q., Mou, H., Yi, H. Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields. Frontiers in Microbiology, 2020, vol. 11 October 2020, p. 1-21, ID Article 582779, https://doi.org/10.3389/fmicb.2020.582779.
 Torres, M. D. T., Sothiselvam, S., Lu, T. K. and de la Fuente-Nunez C. Peptide Design Principles for Antimicrobial Applications. Journal of Molecular Biology, 2019, Vol. 431, p. 3547–3567, https://doi.org/10.1016/j.jmb.2018.12.015.
Dr. Hamilton Cabral
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- database peptides
- therapeutic agents
- peptide design
- antimicrobial peptides
- antibiotic resistance
- therapeutic drugs