The Battle Against Urinary Tract Infections: The Role of Antibiotics

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 1319

Special Issue Editors


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Guest Editor
2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland
Interests: urinary tract infection; antibiotic resistance; urinary incontinence; pelvic organ prolapse, nonantibiotic herbal prophylaxis
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E-Mail Website
Guest Editor
2nd Department of Gynaecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland
Interests: urinary tract infection; antibiotic resistance; urinary incontinence; pelvic organ prolapse, nonantibiotic herbal prophylaxis

Special Issue Information

Dear Colleagues,

We invite submissions for a Special Issue of Antibiotics focused on the topic of urinary tract infections (UTIs) and antibiotic treatment. Urinary tract infections are among the most common bacterial infections, affecting millions globally each year. They pose significant clinical challenges, particularly with the increasing threat of antimicrobial resistance (AMR). This Special Issue seeks original research articles, reviews, and case studies that address various aspects of UTIs, including their pathogenesis, diagnosis, epidemiology, and treatment. We are particularly interested in studies on the role of antibiotics in treating UTIs, the rise of multidrug-resistant uropathogens, novel therapeutic strategies, and antimicrobial stewardship practices. Topics may also explore the development of new antibiotics, alternative treatments such as phage therapy or probiotics, and public health interventions to reduce UTI incidence and antimicrobial misuse. Contributions from diverse disciplines, including microbiology, pharmacology, clinical practice, and public health, are highly encouraged. We aim to provide a platform for advancing our understanding of UTIs and improving patient outcomes through effective and responsible antibiotic use.

Prof. Dr. Pawel Miotla
Dr. Sara Wawrysiuk
Guest Editors

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Keywords

  • urinary tract infection (UTI)
  • antibiotics
  • antimicrobial resistance (AMR)
  • multidrug-resistant uropathogens
  • antibiotic stewardship
  • UTI treatment
  • novel antibiotics
  • phage therapy
  • UTI pathogenesis
  • probiotics in UTI management

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Published Papers (1 paper)

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Research

23 pages, 5390 KiB  
Article
The Clinical Implications of Inappropriate Therapy in Community-Onset Urinary Tract Infections and the Development of a Bayesian Hierarchical Weighted-Incidence Syndromic Combination Antibiogram
by Adolfo Gómez-Quiroz, Brenda Berenice Avila-Cardenas, Judith Carolina De Arcos-Jiménez, Leonardo Perales-Guerrero, Pedro Martínez-Ayala and Jaime Briseno-Ramirez
Antibiotics 2025, 14(2), 187; https://doi.org/10.3390/antibiotics14020187 - 12 Feb 2025
Viewed by 1072
Abstract
Background/Objectives: The rise in multidrug-resistant pathogens complicates UTI management, particularly in empirical therapy. This study aimed to develop and describe a Bayesian hierarchical weighted-incidence syndromic combination antibiogram (WISCA) model to optimize antibiotic selection for adult patients with community-onset UTIs. Methods: A retrospective study [...] Read more.
Background/Objectives: The rise in multidrug-resistant pathogens complicates UTI management, particularly in empirical therapy. This study aimed to develop and describe a Bayesian hierarchical weighted-incidence syndromic combination antibiogram (WISCA) model to optimize antibiotic selection for adult patients with community-onset UTIs. Methods: A retrospective study was conducted using a Bayesian hierarchical model. Data from microbiology laboratory records and medical databases were analyzed, focusing on age, prior antibiotic exposure, and clinical characteristics. Clinical outcomes, including extended hospital stays and in-hospital mortality, were evaluated before WISCA model development. Unlike traditional antibiograms, a WISCA integrates patient-specific factors to improve antimicrobial coverage estimations. A total of 11 monotherapies and 18 combination therapies were tested against 15 pathogens, with posterior coverage probabilities and 95% highest density intervals (HDIs) used to assess coverage. Results: Inappropriate final antibiotic treatment was associated with worse outcomes. The Bayesian framework improved estimations, particularly for rare pathogen–antibiotic interactions, increasing model applicability in high-resistance settings. Combination regimens showed superior coverage, especially in MDR cases and older adults. Conclusions: This study employed a comprehensive methodological approach for WISCA development, enhancing empirical antibiotic selection by incorporating local resistance data and patient-specific factors in a middle-income Latin American country with a high antimicrobial resistance profile. These findings provide a foundation for future clinical applications and antimicrobial stewardship strategies in high-resistance environments. Full article
(This article belongs to the Special Issue The Battle Against Urinary Tract Infections: The Role of Antibiotics)
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