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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Editorial Board Members’ Collection Series: New Strategies to Overcome Antibiotic Resistance

edited by

Francesca Sisto

and

Simone Carradori

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6678 | Submission Open

Keywords: antimicrobial resistance; biofilm; new targets; synthetic drugs; natural compounds; quorum sensing; in vivo models; checkerboard assay; resistance modifiers; probiotics

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Residues, Antimicrobial Resistance and Intervention Strategies of Foodborne Pathogens, 2nd Edition

edited by

Yongning Wu

and

Zhenling Zeng

submission deadline 30 Sep 2025 | 2 articles | Viewed by 6153 | Submission Open

Keywords: antibiotic residues; antibiotic resistance genes; antimicrobial resistance; food safety; foodborne pathogen; intervention strategies; one health

Multidrug-Resistance Patterns in Infectious Pathogens

edited by

José Alejandro Di Conza

and

Barbara Ghiglione

submission deadline 30 Sep 2025 | 5 articles | Viewed by 4575 | Submission Open

Keywords: MDR; DTR; antimicrobial resistance; genomics; surveillance; carbapenemases; MRSA; VISA

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Clinical Gram-Negative Bacteria

edited by

Ángel Rodríguez-Villodres

and José Manuel Ortiz De La Rosa

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4466 | Submission Open

Keywords: carbapenem resistance; Enterobacterales; Pseudomonas aeruginosa; Acinetobacter baumannii; molecular epidemiology

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Companion Animals: Antimicrobial Resistance in Bacterial and Fungal Pathogens Associated with Skin and Ear Infections

edited by

Dominik Łagowski

and

Ewelina Czyzewska-Dors

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2765 | Submission Open

Keywords: dermatophytes; Candida; companion animals; drug susceptibility; Malassezia; mechanisms of resistance; molecular detection; Pseudomonas; Staphylococcus; One Health; MDR; veterinary

(This special issue belongs to the Section Antibiotics in Animal Health)

Genomic Insights and Implications of Emerging Antimicrobial Resistance

edited by

Daniela Bencardino

and

Christian Berens

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2228 | Submission Open

Keywords: antibiotic-resistance; molecular typing; genomic technologies; high-threat pathogens; epidemiological surveillance; emerging and re-emerging infectious diseases; one health approach

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Present and Future of Antibiotic Treatment for Carbapenem-Resistant Enterobacteriaceae

edited by

Dafne Bongiorno

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1664 | Submission Open

Keywords: carbapenem-resistant enterobacteriaceae; antibiotic treatment; antimicrobial resistance; infection prevention; novel therapeutic targets and approaches

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Metal-Based Complexes as Novel Antimicrobial Strategies

edited by

Alberto Aragón-Muriel

Dorian Polo Cerón

and

David Morales-Morales

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1503 | Submission Open

Keywords: antibiotics; metal-based complexes; antimicrobial resistance; antimicrobial therapy; drug design; bioinorganic; metallodrug; metallopharmaceutical

(This special issue belongs to the Section Novel Antimicrobial Agents)

Bone and Joint Infections: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research

edited by

Natividad Benito

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1448 | Submission Open

Keywords: bone and joint infection; arthroplasty infection; definition of bone and joint infection; bone and joint joint infection prevention; diagnosis of bone and joint infection; bone and joint infection management; antimicrobial therapy of bone and joint infection

Genetic Characterization of Antimicrobial Resistance under the One Health Approach

edited by

Sandra M. Quinteira

and

Olga Maria Lage

submission deadline 30 Sep 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: antimicrobial resistance; multidrug-resistant bacteria; resistance genes; mobile genetic elements; molecular mechanisms of resistance; One Health; epidemiology of AMR; AMR surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Molecular Characterization of Multidrug-Resistant Pathogens

edited by

Viviana Cafiso

and

Maria Santagati

submission deadline 30 Sep 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: MDR pathogens; One-Health; genomic; transcriptomic; phylogenomics; molecular epidemiology; AMR

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Antibiotic Resistance in a One Health Context: Bridging Environmental, Agricultural, Nutritional, Veterinary, and Clinical Perspectives

edited by

Pedro A. Jiménez Gómez

and

Marina Robas Mora

submission deadline 30 Sep 2025 | 1 articles | Viewed by 732 | Submission Open

Keywords: antibiotic resistance; One Health; environmental microbiology; zoonotic pathogens; antimicrobial stewardship; resistance mechanisms; horizontal gene transfer; integrated surveillance; microbial ecology; public health

(This special issue belongs to the Section Antibiotics in Animal Health)

Biofilm Formation and Antimicrobial Resistance in Staphylococcus aureus

edited by

Harshad Lade

submission deadline 30 Sep 2025 | Viewed by 531 | Submission Open

Keywords: biofilm formation in S. aureus; antimicrobial resistance; Staphylococcus aureus; biofilm formation; antibiofilm

(This special issue belongs to the Section Antibiofilm Strategies)

Innovative Antimicrobial Strategies to Combat Antibiotic Resistance

edited by

Chenxi Huang

and

Xiaohong Wang

submission deadline 30 Sep 2025 | Viewed by 317 | Submission Open

Keywords: nanotechnology applications; diagnostic strategies; phages-mediated strategies; foodborne pathogens; antibiotics; antimicrobial; multi-drug resistance; biocontrol

(This special issue belongs to the Section Novel Antimicrobial Agents)

Epidemiology and Antimicrobial Dosing Regimens in Intensive Care Units

edited by

Philipp Simon

submission deadline 30 Sep 2025 | Viewed by 244 | Submission Open

Keywords: epidemiology; critical care; sepsis; empiric therapy; dosing; interactions; antibiotic resistance; therapeutic drug monitoring; pharmacokinetics/pharmacodynamics; renal insufficiency; renal replacement therapy

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Genomic Surveillance of Antimicrobial Resistance (AMR)

edited by Linzy Elton

submission deadline 30 Sep 2025 | Viewed by 234 | Submission Open

Keywords: antimicrobial resistance; sequencing; genomics; surveillance; mobile genetic elements; multi-drug-resistant organisms; One Health; metagenomics; whole-genome sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

A Themed Issue in Honor of Prof. Dr. Rob Capon—Outstanding Contributions in the Field of Anti-Infectives

edited by Mark Butler

submission deadline 30 Sep 2025 | Viewed by 176 | Submission Open

Keywords: natural product; microorganism; bacteria; fungi; marine antibiotic; antibacterial; antheminthic; crop protection

(This special issue belongs to the Section Novel Antimicrobial Agents)

Emerging Contaminants: Antibiotic Residues and Their Environmental Impact

edited by

Xuxiang Zhang

Liping Ma

and Peng Liu

submission deadline 30 Sep 2025 | Viewed by 154 | Submission Open

Keywords: antibiotics; antimicrobial resistance; environmental behavior; environmental pollution; health risk; high-throughput sequencing; resistome; non-target screening

Surveillance and Assessment of Antimicrobial Resistance Patterns and Antimicrobial Utilization in Hospital Settings

edited by Hao-Yuan Lee

submission deadline 30 Sep 2025 | Viewed by 150 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial stewardship; hospital-acquired infections; surveillance systems; antibiotic prescribing practices; infection prevention and control; diagnostic tools in AMR; resistance trends in healthcare; epidemiology of AMR; multidrug-resistant organisms (MDROs)

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Biomaterial-Based Delivery Systems for Natural Antimicrobials to Overcome Microbial Resistance

edited by

Ioana Cristina Marinas

Irina Gheorghe-Barbu

and Ilda Czobor-Barbu

submission deadline 30 Sep 2025 | Viewed by 146 | Submission Open

Keywords: antimicrobial resistance (AMR); virulence and pathogenicity; phytocompounds; biomaterials; controlled release; nanoparticles; biopolymers; targeted delivery; biofilm prevention; sustainable therapeutics

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Antimicrobial Bioactives from Invertebrates

edited by

Beatriz Vázquez Belda

submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open

Keywords: invertebrates; bioactive compounds; antimicrobials; antibacterial activity; marine invertebrates; insects; worms; crustaceans; mollusks

(This special issue belongs to the Section Novel Antimicrobial Agents)

Molecular Epidemiology and Antibiotic Resistance in MRSA: Recent Advances in Surveillance and Control

edited by

Jae-Seok Kim

submission deadline 30 Sep 2025 | Viewed by 129 | Submission Open

Keywords: Staphylococcus aureus; methicillin-resistant S. aureus (MRSA); hospital-associated MRSA (HA-MRSA); antimicrobial resistance; molecular epidemiology; evolution of resistance; surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Activity of Medical Materials, 2nd Edition

edited by Tânia Grainha and Susana Lopes

submission deadline 30 Sep 2025 | Viewed by 119 | Submission Open

Keywords: antimicrobial surfaces; copper; silver; surface functionalization/modifications; biofilm prevention; medical textiles; efficiency

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Application of Bacteriophages Against Bacterial Survival Strategies

edited by Sang Guen Kim

submission deadline 30 Sep 2025 | Viewed by 101 | Submission Open

Keywords: bacteriophage; phage therapy; application of phages; biofilm; persister cells; viable but non-culturable (VBNC)

(This special issue belongs to the Section Bacteriophages)

Epidemiology and Genomics of Antimicrobial Resistance of Difficult-to-Treat Pathogens

edited by Simone Ambretti

submission deadline 30 Sep 2025 | Viewed by 70 | Submission Open

Keywords: antimicrobial resistance; difficult-to-treat pathogens; epidemiology; genomics; MRSA; VRE; ESBL; CRE; CRAB; MDR pseudomonas aeruginosa

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Addressing the Challenge of Antibiotic Resistance with Existing Antibiotics

edited by Xuanxian Peng

submission deadline 5 Oct 2025 | 1 articles | Viewed by 1212 | Submission Open

Keywords: antibiotic resistance; antibacterial agents; metabolites; antibiotic-resistant bacteria

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Microbial Resistance Surveillance and Management in Food Systems

edited by

Carlos Adam Conte Júnior

and

Bruno Dutra da Silva

submission deadline 10 Oct 2025 | 6 articles | Viewed by 6611 | Submission Open

Keywords: cross-contamination; microbial resistance; microbial monitoring; public health; alternative antimicrobials; foodborne illnesses; food microbiology

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach

edited by

George Cosmin Nadǎş

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1651 | Submission Open

Keywords: antimicrobial resistance; veterinary microbiology; MDR; one health; zoonotic

(This special issue belongs to the Section Antibiotics in Animal Health)

Perspective on the Role of Farm Animals in the Transmission of Antimicrobial Resistance from a One Health Approach

edited by

Romeo Teodor Cristina

and

Degi Janos

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1595 | Submission Open

Keywords: antimicrobials use; farm animals; antimicrobial resistance; one health; antimicrobials; food safety; public health

(This special issue belongs to the Section Antibiotics in Animal Health)

Nanotechnology-Based Antimicrobials and Drug Delivery Systems

edited by

Mihai Valentin Predoi

Simona Liliana Iconaru

and

Carmen Steluta Ciobanu

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1437 | Submission Open

Keywords: antimicrobial agents; nanocarriers; antimicrobial coatings; polymers nanocomposite; drug delivery systems

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Antimicrobial Activity of Metal-Based Nanoparticles

edited by Suzan Pantaroto de Vasconcellos

submission deadline 15 Oct 2025 | 1 articles | Viewed by 1168 | Submission Open

Keywords: metal-nanoparticle; microbicide; virucide; phytopathogens; disinfectant; synthesis; antibiotic resistance

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Fighting the Superbug Surge: Strategies in Antimicrobial Stewardship and Infection Control

edited by Sara Revolinski, Kristen Bresnehan and Lucas Schulz

submission deadline 15 Oct 2025 | Viewed by 216 | Submission Open

Keywords: antimicrobial stewardship; infection control; infection prevention; multidrug resistant organisms; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Role of the Gut Microbiome in Antibiotic Resistance and Therapy: Mechanisms and Implications

edited by

Dóra Szabó

submission deadline 15 Oct 2025 | Viewed by 120 | Submission Open

Keywords: gut microbiome; antibiotic resistance; antibiotic therapy; pre- and probiotics; horizontal gene transfer; ESBL-producing enterobacterales; Carbapenem-resistant enterobacterales; intestinal colonization; clostrioides difficile; fecal microbiota transplantation (FMT)

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Revolutionizing Infection Treatment: Cutting-Edge Approaches in Antimicrobial Stewardship

edited by Jacob Myles Keck and

Aleksandra Barac

submission deadline 30 Oct 2025 | Viewed by 218 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; infection treatment optimization; rapid diagnostics; technology in healthcare

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance and Epidemiological Study of Clinically Relevant Pathogens

edited by

Florin George Horhat

Adrian Man

and

Delia Muntean

submission deadline 31 Oct 2025 | 8 articles | Viewed by 19891 | Submission Open

Keywords: antibacterial activity; antimicrobial resistance; infections; multidrug-resistant pathogens; virulence gene expression; drug discovery; epidemiological study

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobials Agents: Latest Advances and Prospects

edited by

Marius Stefan

submission deadline 31 Oct 2025 | 7 articles | Viewed by 18319 | Submission Open

Keywords: multidrug-resistant pathogens; infectious diseases; antibiotic resistance; new antimicrobials; drug development; antimicrobial activity; structure– activity relationship (SAR); antimicrobial therapy

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Resistance in Clinical Infection and Antibiotic Stewardship

edited by

Daniel T. Anderson

submission deadline 31 Oct 2025 | 6 articles | Viewed by 17824 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; treatment; antimicrobials

Antibiofilm Activity against Multidrug-Resistant Pathogens

edited by

Verica Aleksic Sabo

and Petar Knezevic

submission deadline 31 Oct 2025 | 6 articles | Viewed by 15990 | Submission Open

Keywords: biofilm; microbial drug resistance; antibiofilm agents; antibiofilm strategies; synergistic interactions

(This special issue belongs to the Section Antibiofilm Strategies)

Mechanism of Carbapenem Resistance in Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa

edited by

Ágnes Pál-Sonnevend

submission deadline 31 Oct 2025 | 5 articles | Viewed by 15942 | Submission Open

Keywords: gram-negative infections; mechanism of carbapenem resistance; molecular epidemiology; in vitro diagnostic tools; antimicrobial treatment; beta-lactam/beta lactamase inhibitors; cefiderocol

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Insights into Natural Antimicrobial Peptides

edited by

András Fodor

Eustachio Tarasco

and

Maurizio Francesco Brivio

submission deadline 31 Oct 2025 | 4 articles | Viewed by 12476 | Submission Open

Keywords: antibacterial host defense peptides; antibacterial mode of action; defensins; cathelicidins; insect antimicrobial peptides; plant antimicrobial peptides

(This special issue belongs to the Section Antimicrobial Peptides)

Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

edited by Janet D. Conway

submission deadline 31 Oct 2025 | 4 articles | Viewed by 10920 | Submission Open

Keywords: bone infection; joint infection; periprosthetic joint infection; orthopaedic infection; orthopedic infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

New Paradigms Concerning the Production of Antibiotics: Between Ecological Responsibility and Revalorization of Narrow Spectrums

edited by

Véronique Mondain

submission deadline 31 Oct 2025 | 3 articles | Viewed by 9352 | Submission Open

Keywords: one health; environmental pollution; human health; antimicrobial production; livestock; antimicrobial resistance; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

New Approaches in Antimicrobial Drug Discovery and Design

edited by

Robert Penchovsky

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5468 | Submission Open

Keywords: rational drug design; multi-drug resistant human pathogenic bacteria; new antibiotics; antibacterial drugs; antibacterial drug targets; in silico drug target evaluation

(This special issue belongs to the Section Novel Antimicrobial Agents)

Strategies to Combat Antibiotic Resistance and Microbial Biofilms

edited by

Isabella Macário Ferro Cavalcanti

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5412 | Submission Open

Keywords: antibiotic resistance; biofilms; nanotechnology; medicinal plants; synthetic

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance: From the Bench to Patients, 2nd Edition

edited by

Fernando Albericio

and

Márió Gajdács

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5373 | Submission Open

Keywords: antimicrobial resistance; infectious disease epidemiology; multidrug resistance; clinical bacteriology; antimicrobial stewardship; self-medication; knowledge– attitude– practice (KAP); regulatory perspectives; drug utilization; policy analysis; primary care; pharmacy; novel antimicrobial drugs; laboratory testing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Emerging Topics in Clostridioides difficile Infection: A One Health Problem

edited by

Simon D. Baines

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4924 | Submission Open

Keywords: clostridium difficile infection (CDI); antimicrobial resistance (AMR); antimicrobial prescribing; one health; laboratory studies

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Biofilms and Urinary Tract Infections

edited by

Dino Sgarabotto

and

Anabela Borges

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3981 | Submission Open

(This special issue belongs to the Section Antibiofilm Strategies)

Antimicrobial Resistance and Zoonoses, 2nd Edition

edited by

Marina Spînu

and

Magdalena Rzewuska

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2889 | Submission Open

Keywords: antibiotics; antimicrobial resistance; antimicrobial resistance genes; monitoring; one health; pathogen transmission; resistance mechanisms; surveillance; zoonotic pathogens; zoonosis

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2761 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Microbial Natural Products as a Source of Novel Antimicrobials, 2nd Edition

edited by