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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antimicrobials Agents: Latest Advances and Prospects

edited by

Marius Stefan

submission deadline 30 Jun 2026 | 8 articles | Viewed by 49508 | Submission Open

Keywords: multidrug-resistant pathogens; infectious diseases; antibiotic resistance; new antimicrobials; drug development; antimicrobial activity; structure– activity relationship (SAR); antimicrobial therapy

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Spread of Antibiotic Resistance in Natural Environments

edited by

Daniel Gyamfi Amoako

submission deadline 30 Jun 2026 | 7 articles | Viewed by 38796 | Submission Open

Keywords: antibiotic resistance dissemination; antibiotic pollution; environmental adaptation; mobile genetic elements; ecological impact; environmental microbiome; resistance gene transfer; resistance hotspot; genomic landscape; One Health approach; emerging contaminants; bioinformatics in environmental genomics

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

edited by Janet D. Conway

submission deadline 30 Jun 2026 | 6 articles | Viewed by 29255 | Submission Open

Keywords: bone infection; joint infection; periprosthetic joint infection; orthopaedic infection; orthopedic infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Comprehensively Addressing Antimicrobial Resistance, Improving Food Safety and Achieving the One Health Goals: Global Challenges

edited by

Vladimir Kurćubić

, Pavle Mašković,

Milan N. Mitić

and

Nikola Stanišić

submission deadline 30 Jun 2026 | 5 articles | Viewed by 13406 | Submission Open

Keywords: antimicrobial resistance (AMR); food safety; foodborne pathogens; antibiotic residues; natural antimicrobials; one health

Diagnostics, Antibiotic Usage and Surgery Related Techniques in Prevention and Treatment of Prosthetic Joint and Implant Related Infections

edited by

Bernd Fink

and

Steffen Ruchholtz

submission deadline 30 Jun 2026 | 5 articles | Viewed by 13256 | Submission Open

Keywords: periprosthetic joint infection; implant-related infection; antibiotics; spacer; diagnosis; septic revision arthroplasty; irrigation; debridement

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 30 Jun 2026 | 4 articles | Viewed by 11665 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

Discovery and Development of Novel Antibacterial Agents—2nd Edition

edited by

Kui Zhu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10886 | Submission Open

Keywords: antibiotic discovery; antibacterial target; mode of action; natural product

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Issue of Multidrug-Resistant Pathogens in Nosocomial Infections, 2nd Edition

edited by

Alberto Enrico Maraolo

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10630 | Submission Open

Keywords: antimicrobial resistance; MDR; XDR; DTR; nosocomial infections

Small Intestinal Bacterial Overgrowth and Antimicrobials

edited by

Mislav Radić

and

Andrej Belančić

submission deadline 30 Jun 2026 | 1 articles | Viewed by 10344 | Submission Open

Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome

(This special issue belongs to the Section Novel Antimicrobial Agents)

Pharmacokinetics and Pharmacodynamics of Antibacterial and Antivirulence Drugs, 2nd Edition

edited by

Takahisa Yano

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10052 | Submission Open

Keywords: pharmacokinetics; pharmacodynamics; clinical trials; antimicrobial resistance; antibacterials; antivirulence drugs; pathoblockers; antimicrobial use; drug utilization studies; PK/PD modeling; PBPK-modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Antibiotic Utilization and Resistance Patterns in Perioperative and Surgical Settings

edited by Massimo Sartelli

submission deadline 30 Jun 2026 | 1 articles | Viewed by 7469 | Submission Open

Keywords: antimicrobial resistance; surgical antibiotic prophylaxis; antibiotic therapy

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 30 Jun 2026 | 2 articles | Viewed by 7160 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

A Themed Issue in Honor of Dr. Lynne V. McFarland—Clostridioides difficile Infection and Impact of Antibiotics on the Intestinal Microbiome

edited by Ellie J. C. Goldstein and Shan Goh

submission deadline 30 Jun 2026 | 3 articles | Viewed by 7115 | Submission Open

Keywords: Clostridioides difficile infections; intestinal microbiome; infection control practices; antibiotic complications; probiotics; live biotherapeutic products; treatment; prevention

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Natural Compounds as Antimicrobial Agents, 3rd Edition

edited by

Carlos M. Franco

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6004 | Submission Open

Keywords: new natural antimicrobial compounds; antimicrobial effects; clinical applications; animal production applications; antifungal properties; antiviral properties; food applications; new formulations; antibacterial mechanisms; antifungal mechanisms; MICs; activity as disinfectants; activity against biofilms; effects on transcriptomics; combination with other antimicrobials; global microbiome changes

(This special issue belongs to the Section Novel Antimicrobial Agents)

Bacterial Extracellular Vesicles: Vehicles for Pathogenesis and Antibiotic Resistance

edited by

Eva Sapi

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5527 | Submission Open

Keywords: bacterial extracellular vesicles (BEVs); outer membrane vesicles (OMVs); antibiotic resistance; pathogenesis; host-pathogen interaction

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

New Drugs, Innovative Antimicrobial Approaches, and Optimized Dosages: Bridging Research and Clinical Practice

edited by

Jerónimo Pachón

, Rocío Álvarez-Marín and

María E. Pachón-Ibáñez

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5230 | Submission Open

Keywords: antibiotics; antivirals; pharmacokinetics and pharmacodynamics; clinical evaluation; experimental studies; new antimicrobial approaches

Novel Approaches to Prevent and Combat Antimicrobial Resistance

edited by

Xiaotao Jiang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 5077 | Submission Open

Keywords: antimicrobial peptides; novel antibiotics screening; phage therapy; fecal microbiota transplantation (FMT); dietary and functional food interventions; AMR prevention strategies

Antibiotic Stewardship and Infection Control Strategies in Critical Care

edited by

Susana M. Fernandes

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4818 | Submission Open

Keywords: infection prevention; critical care; sepsis; stewardship practices

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance in the Wildlife

edited by

Francesca Piras

and Giuliana Siddi

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3686 | Submission Open

Keywords: wildlife; wild animal; antimicrobial resistance; transmission; spread; One Health

Antibiotic Resistance in Geriatric Emergency Patients: Challenges and Strategies for Optimal Management

edited by

Sung Jin Bae

and

Dong-Hoon Lee

submission deadline 30 Jun 2026 | 4 articles | Viewed by 3349 | Submission Open

Keywords: antibiotic resistance; geriatric emergency medicine; antimicrobial stewardship; multidrug-resistant organisms

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology, 2nd Edition

edited by

Theodoros Karampatakis

and

Katerina Tsergouli

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3197 | Submission Open

Keywords: Gram-negative bacteria; virulence factors; antimicrobial resistance; molecular epidemiology; Klebsiella pneumoniae; Pseudomonas aeruginosa; Acinetobacter baumannii

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Recent Developments in Antimicrobial Resistance Epidemiology and Antimicrobial Therapy for Clinically Relevant Bacteria

edited by

Georgios Meletis

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2812 | Submission Open

Keywords: antimicrobial resistance mechanisms; antimicrobial resistance detection; antimicrobial resistance epidemiology; antimicrobial treatment; MDR; Klebsiella pneumoniae; Acinetobacter baumannii; Pseudomonas aeruginosa; MRSA; VRE

Plant-Based Strategies for the Removal and Degradation of Antibiotics from the Environment

edited by

Giancarlo Angeles Flores

and

Paola Angelini

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2520 | Submission Open

Keywords: antibiotics; ARGs; phytoremediation; rhizosphere; plant– microbe interactions; biodegradation; detoxification; environmental pollution; resistance mitigation; sustainable remediation

Mastitis: Causative Agents, Drug Resistance, and Treatment Approaches—2nd Edition

edited by

Amira A. Moawad

Hosny El-Adawy

and Heinrich Neubauer

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2185 | Submission Open

Keywords: mastitis; etiology; multi-drug resistance; alternative bovine mastitis treatment; WGS

(This special issue belongs to the Section Antibiotics in Animal Health)

Antibiotic Resistance in Agricultural Environments: Emergence, Drivers and Mitigation

edited by

Guyue Cheng

and Juan Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1890 | Submission Open

Keywords: antibiotic resistance (AMR); animal husbandry; environmental resistome; livestock microbiome; co-selection; agricultural environments; One Health; antibiotic resistance genes (ARGs); heavy metals; selective pressures

(This special issue belongs to the Section Antibiotics in Animal Health)

Feature Reviews in Antibiotic Therapy for Infectious Diseases 2026

edited by

Karolina Akinosoglou

and

Mehran Monchi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1069 | Submission Open

Keywords: antibiotic resistance; antibiotic therapy; infectious diseases; novel antimicrobial agents; alternative therapeutic strategies; antibiotic prescribing; antimicrobial stewardship

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Marine-Derived Antibiotics

edited by

Ines Mancini

and

Andrea Defant

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1050 | Submission Open

Keywords: marine natural products; structural characterization; improved production of bioactive secondary metabolites; organic synthesis; structure– activity relationship (SAR); pathogen bacteria inhibition; antibiofilm activity; computational analysis; drug discovery; drug delivery systems

(This special issue belongs to the Section Novel Antimicrobial Agents)

Plants, Lichens, Fungi, and Algae Extracts and Derivatives with Antimicrobial Properties for Nutrition and Health, Second Edition

edited by

Violeta Popovici

Emma Adriana Ozon

Andreea Letitia Arsene

and

Verginica Schroder

submission deadline 30 Jun 2026 | Viewed by 715 | Submission Open

Keywords: antimicrobial and antibiofilm activity; plants/lichens/fungi/algae extracts and derived products with antibacterial; antifungal; antiviral; antiprotozoal and antihelmintic properties; antimicrobial metabolites: quantification and characterization; pharmaceutical formulation; in vivo and in vitro testing; essential oils with antimicrobial properties for the pharmaceutical and food industry; functional foods; plant-based diet; case studies; prevention and treatment of infectious diseases with plant-derived products

(This special issue belongs to the Section Plant-Derived Antibiotics)

The Discovery of Novel Beta-Lactams and Beta-Lactamase Inhibitors

edited by

Caitlyn Thomas

and

Juhee Ahn

submission deadline 30 Jun 2026 | Viewed by 708 | Submission Open

Keywords: antibiotic resistance; β -lactam antibiotics; β -lactamase inhibitors; drug discovery; metallo-β -lactamases; serine-β -lactamase

Antimicrobial Agents Targeting Biofilms

edited by

Domenico Schillaci

submission deadline 30 Jun 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: biofim associated infections; virulence factors; antibiofilm agents

Biosynthesis, Antimicrobial Activity, and Therapeutics Development of Novel Peptides

edited by

Jiajun Wang

submission deadline 30 Jun 2026 | Viewed by 403 | Submission Open

Keywords: peptide biosynthesis; novel antimicrobial peptides; antibiotic resistance; improvement of biological stability; optimization of drug delivery systems; immune regulation; AI-driven peptide design; innovation in the field of biomedicine

(This special issue belongs to the Section Antimicrobial Peptides)

New Approaches to the Treatment and Prevention of Fungal Infections

edited by

Célia Fortuna Rodrigues

submission deadline 30 Jun 2026 | Viewed by 395 | Submission Open

Keywords: biofilms; AMR; antifungals; infections; alternative treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Novel Antimicrobial Agents for Treatment of Staphylococcus aureus Infections

edited by

William Schwan

submission deadline 30 Jun 2026 | Viewed by 389 | Submission Open

Keywords: Staphylococcus aureus; novel antimicrobials; antibiotics; new mechanism of action

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Advances in Antibiotic Synergy and Combination Therapy for Multidrug-Resistant Infections

edited by

Vasiliki Koumaki

submission deadline 30 Jun 2026 | Viewed by 349 | Submission Open

Keywords: multidrug-resistant (MDR); synergistic antibiotic combinations; novel antibiotic pairings; phage– antibiotic synergy; pharmacokinetic/pharmacodynamic modeling

Strategies for Combatting Multidrug-Resistant and Extensively Drug-Resistant Bacteria, 3rd Edition

edited by

Bożena Futoma-Kołoch

and Anna Kędziora

submission deadline 30 Jun 2026 | Viewed by 263 | Submission Open

Keywords: MDR bacteria; EDR bacteria; novel antimicrobial drugs; novel therapeutical approaches against MDR; novel therapeutical approaches against EDR; guidelines; personalized microbiota; bacteriophages; autovaccine therapy; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Evolution, Dissemination and Counteraction of Last-Resort Antimicrobial Resistance in Gram-Negative Pathogens

edited by

Katarina Novović

submission deadline 30 Jun 2026 | Viewed by 184 | Submission Open

Keywords: last-resort antimicrobial resistance; gram-negative pathogens; evolutionary dynamics; horizontal gene transfer; genomic epidemiology; novel therapeutic options

Discovery and Design of New Antimicrobial Agents, 2nd Edition

edited by

Jean Michel Brunel

submission deadline 10 Jul 2026 | Viewed by 244 | Submission Open

Keywords: antimicrobial agents; fight resistance; new design; structure– activity relationships (SARs)

(This special issue belongs to the Section Novel Antimicrobial Agents)

Surveillance and Molecular Diagnosis of Antimicrobial-Resistant Pathogens: From Laboratory to Clinical Practice

edited by Neena Kanwar

submission deadline 20 Jul 2026 | Viewed by 333 | Submission Open

Keywords: clinical microbiology; molecular diagnostics; infectious disease epidemiology; antimicrobial susceptibility; microbial culture

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms

edited by

Silvia Di Lodovico

submission deadline 30 Jul 2026 | 2 articles | Viewed by 956 | Submission Open

Keywords: multidrug-resistant microorganisms; antimicrobial resistance; epidemiological surveillance; infection prevention and control; antimicrobial stewardship; one health; public health interventions

Gram-Positive Cocci: Antimicrobial Resistance, Treatment, Susceptibility, and New Therapeutic Options

edited by

Felipe Piedade Gonçalves Neves

submission deadline 30 Jul 2026 | Viewed by 713 | Submission Open

Keywords: Streptococcus spp.; Enterococcus spp.; Staphylococcus spp.; antimicrobial resistance; molecular epidemiology; new therapeutic options

From Detection to Treatment: Navigating Urinary Tract Infections with Antibiotics

edited by

Eleonora Nicolai

submission deadline 31 Jul 2026 | 4 articles | Viewed by 24481 | Submission Open

Advancing and Standardising Antimicrobial Susceptibility and Resistance Detection Methodology

edited by

Owen B. Spiller

submission deadline 31 Jul 2026 | 11 articles | Viewed by 18944 | Submission Open

Keywords: antimicrobial susceptibility testing; resistance screening; rapid diagnostics; clinical; veterinary; environmental; validation

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advancing the Discovery and Development of New Antibiotics through Drug Repurposing

edited by Songping Huang

submission deadline 31 Jul 2026 | 7 articles | Viewed by 17702 | Submission Open

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance in Wastewater Treatment Plants

edited by Qingbin Yuan

submission deadline 31 Jul 2026 | 7 articles | Viewed by 15014 | Submission Open

Keywords: antibiotic resistance genes; wastewater treatment; one health; distribution and removal of ARGs; horizontal gene transfer

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Multitalented Synthetic Antimicrobial Compounds: From Design to Effect

edited by

Tsz Tin Yu

and

Maria Fernanda N. N. Carvalho

submission deadline 31 Jul 2026 | 6 articles | Viewed by 14418 | Submission Open

Keywords: antimicrobial resistance; antibiotic development; the design of antimicrobial compounds; the synthesis of antimicrobial compounds; medicinal chemistry; bioorganic chemistry; antimicrobial properties; the mechanisms of antimicrobial activity; bioinorganic

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 31 Jul 2026 | 5 articles | Viewed by 13305 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Natural Peptides to Combat Conventional Antibiotic Resistance

edited by

Christopher Shaw

Tianbao Chen

and

Lei Wang

submission deadline 31 Jul 2026 | 3 articles | Viewed by 13177 | Submission Open

Keywords: antimicrobial peptide; peptide modification; antibiotic resistance; structure– activity relationship; membrane selectivity; resistant strains

(This special issue belongs to the Section Antimicrobial Peptides)

Global Strategies for Antimicrobial Surveillance: Country, Regional and Global Perspectives

edited by

Gustavo Horacio Marin

and Gabriel Levy-Hara

submission deadline 31 Jul 2026 | 8 articles | Viewed by 12398 | Submission Open

Keywords: antimicrobial; stewardship; resistance; consumption; use

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Clostridioides difficile Infection, 3rd Edition

edited by

Guido Granata

submission deadline 31 Jul 2026 | 4 articles | Viewed by 9207 | Submission Open

Keywords: Clostridioides difficile; Clostridioides difficile infection recurrence; antimicrobial use; host and microbiota interaction; CDI

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Neonatal Infection: Antibiotics for Prevention and Treatment

edited by Cinzia Auriti and Maria Paola Ronchetti

submission deadline 31 Jul 2026 | 6 articles | Viewed by 9008 | Submission Open

Keywords: neonatal infections; neonatal sepsis; sepsis definition; antibiotics in newborns; antibiotic stewardship; sepsis biomarkers; sepsis diagnosis in newborns; epidemiology of neonatal infections; fungal invasive infections

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