Antimicrobial Activity of Natural Products and Plants Extracts, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 432

Special Issue Editors


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Guest Editor
Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, 400372 Cluj-Napoca, Romania
Interests: antimicrobial assays; biological activities of natural products; herbal extracts; antimicrobial resistance; zoonotic bacteria
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Guest Editor
Faculty of Pharmacy, Iuliu Hațieganu Medicine and Pharmacy University, 400012 Cluj-Napoca, Romania
Interests: phytochemistry; biological activities of plant-origin bioactive compounds; chromatography
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Special Issue Information

Dear Colleagues,

The first edition of the Special Issue “Antimicrobial Activity of Natural Products and Plants Extracts” was published in 2023. It is a successful collection with 10 excellent papers and has encouraged us to open a second edition with the same topic.

As a continuation of the first Special Issue, this second edition aims to discuss the different aspects of the antimicrobial potential of natural products, including screening of antimicrobial potential, the antimicrobial efficacy of natural products and plant extracts correlated to their chemical composition and/or other biological properties, interconnected pathways, and mechanisms of action, synergism, and standardization.

Manuscripts reporting on the plant extracts antimicrobial screening based on basic methodologies (such as zone-of-inhibition assays) and non- standardized protocols will not normally be considered for publication in this Section. The antimicrobial activities should be further quantified by MIC, IC50, or other statistical determinations. Furthermore, manuscripts dealing with plant extracts evaluation that does not include chemical characterization will not normally be considered for publication.

Dr. Mihaela Niculae
Dr. Daniela Hanganu
Guest Editors

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Keywords

  • natural products
  • plant extracts
  • bioactive compounds
  • phytoconstituents
  • antibacterial efficacy
  • in vitro screening
  • in vivo evaluation
  • antibiofilm
  • anti-quorum

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Published Papers (1 paper)

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Research

18 pages, 828 KB  
Article
Antimicrobial Profile of Moldovan Cynara scolymus L.: Insights into Its Natural Antibiotic Potential
by Cristina Ciobanu, Ludmila Rudi, Laurian Vlase, Greta Balan, Daniela Benedec and Tatiana Calalb
Antibiotics 2025, 14(12), 1258; https://doi.org/10.3390/antibiotics14121258 - 12 Dec 2025
Abstract
Background: Artichoke, a medicinal plant with various therapeutic uses, is widely cultivated in many of the world’s geographical areas. The aim of this study was to establish the antimicrobial profile by means of comparative evaluation of the phytochemical constituents, antioxidant, anti-lipid peroxidation, [...] Read more.
Background: Artichoke, a medicinal plant with various therapeutic uses, is widely cultivated in many of the world’s geographical areas. The aim of this study was to establish the antimicrobial profile by means of comparative evaluation of the phytochemical constituents, antioxidant, anti-lipid peroxidation, and antimicrobial activities of the basal and cauline leaves, as well as the following by-products: stems, bracts, and inflorescences, from Cynara scolymus L. cultivated in the Republic of Moldova. Methods: Qualitative and quantitative characterization of the main phenolic compounds from ethanolic extracts was carried out by the HPLC-UV-MS method. The in vitro antioxidant activity was evaluated using DPPH˙, ABTS˙+, FRAP, and NO˙ scavenging methods. The lipid-lowering effect was established with a malonic dialdehyde complex and thiobarbituric acid. Antimicrobial properties were screened using the diffusion method. Results: The HPLC UV-MS analysis highlighted that the green aerial parts of C. scolymus are characterized by the presence of five phenolic acids (kaempferol, gentisic, chlorogenic, p-coumaric, ferulic, and caffeic) and four flavonoid heterosides and aglycones (isoquercitrin, quercitrin, luteolin, and apigenin). Correlation between total polyphenolic content and antioxidant activity was found to be statistically significant (p < 0.01). The extracts of C. scolymus’s aerial parts exhibited significant antibacterial and antifungal activities (p < 0.05) against all tested microorganisms, while no inhibitory effect for inflorescences was observed. Conclusions: Artichoke leaves and by-products may be considered important and promising sources of bioactive compounds for herbal medicinal products, functional foods, and nutraceuticals, due to their antimicrobial properties. This study makes an original contribution to the specialized literature by the detailed characterization of the antimicrobial profile of the extracts obtained from artichoke cultivated in the Republic of Moldova, a species introduced for the first time on the territory of this country. The obtained results highlight the medicinal potential and economic value of the Moldovan artichoke, with particular emphasis on its by-products: stems, bracts, and inflorescences, which less explored so far, as sources of bioactive compounds. Our analyses indicate that the leaves and by-products of the plant represent promising resources for the development of phytopharmaceutical preparations, functional foods, and nutraceuticals, offering new directions for the integral and sustainable valorization of this species acclimatized in Moldova. Full article
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