Antimicrobial Agents for Drug-Resistant Infections: From Identification to Preclinical and Clinical Trials
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 66
Special Issue Editors
Interests: peptide synthesis; antimicrobial and anticancerigenic peptides; glycopeptides; organometallic peptides
Special Issues, Collections and Topics in MDPI journals
Interests: peptide synthesis; peptide therapeutic application; peptide analysis by HPLC and MS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance, in both antimicrobial and anticancer therapies, arises when pathogens or cancer cells become less susceptible to drugs, reducing treatment efficacy. This growing health threat requires urgent multisectoral action to achieve the Sustainable Development Goals (SDGs) and imposes a significant economic burden due to prolonged hospital stays, higher healthcare costs, and premature mortality.
Multidrug-resistant and pan-resistant bacterial strains, causing infections untreatable with current antibiotics, are a critical concern. According to the World Health Organization (WHO), the clinical development pipeline for new antimicrobials is severely depleted. A 2019 report found that of 32 antibiotics in development, only 6 were considered innovative, underscoring the need for novel therapeutic approaches.
Peptides, both antimicrobial and anticancer, have emerged as promising alternatives due to their synthetic flexibility, favorable safety profiles, and lower propensity to induce resistance compared to small-molecule drugs.
This Special Issue seeks to compile research on identifying new antimicrobial and anticancer agents, including proteins, peptides, and amino acids, with or without non-protein components such as organic moieties, sugars, lipids, and organometallic compounds. Multidisciplinary strategies to discover bioactive molecules are essential for expanding therapeutic options capable of overcoming drug resistance and restoring treatment efficacy.
Prof. Dr. Javier Eduardo García Castañeda
Dr. Zuly Jenny Rivera-Monroy
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antimicrobials agents
- drug resistant
- anti-cancerogenic agents
- drug development
- preclinical trials
- clinical trials
- pharmaceutical optimization
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