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This study evaluates wavelength-dispersive X-ray fluorescence (WDXRF) for the quantification of iron and other major elements in archeological ochre, employing a borate-flux fusion technique adapted for small sample quantities. Cross-sectional microX...

Developing efficient, non-enzymatic glucose sensors is crucial for overcoming the stability and environmental limitations of conventional enzymatic devices. In this work, a series of ruthenium-based bimetallic microstructures (Ru–Ir, Ru–P...

The accurate determination of vitamin B12 in fortified food products presents considerable analytical challenges due to its low concentrations (μg kg⁻¹) and its binding to proteins in dairy products. This study aimed to develop a reliable an...

Lipid metabolites in maize kernels determine grain quality by influencing nutritional value, oxidative stability, and post-harvest deterioration, making their profiling essential for quality improvement and breeding. This study applies hyperspectral...

The global reliance on commodity oils has intensified the search for alternative plant-based sources capable of meeting increasing worldwide demand. The utilization of fruits from the Brazilian Savanna and their associated byproducts offers numerous...

Distal-less homeobox 1 (DLX1) has emerged as a promising urinary biomarker for prostate cancer. This study developed a label-free piezoelectric acoustic biosensor for selective DLX1 detection using a quartz crystal microbalance (QCM). The QCM gold el...

Brown algae, such as Dictyota dichotoma, contain fucoidan, whose bioactivity is linked to its molecular characteristics, which are in turn defined by environmental conditions. D. dichotoma fucoidan from the Sea of Cortez in Mexico (DDFSC) has not bee...

Sulforaphane (SFN), an isothiocyanate abundant in cruciferous vegetables, possesses well-documented anticancer, antioxidant, and anti-inflammatory properties, and has attracted interest as a dietary chemopreventive agent. However, sensitive and fully...

Density measurement with vibrating tube density meters is a fundamental technique in biotechnology, for example, as the metrological base for spectroscopy calibrations. However, conventional multi-point adjustments frequently rely on hazardous haloge...

Synthetic azo dyes are relevant paprika adulterants and a food-safety concern when used in undeclared or non-authorized forms. This study investigated the quantification of three representative dyes—Allura Red (E129), Orange II, and Ponceau 4R...

Microplastic contamination has become an emerging environmental concern in marine ecosystems worldwide. This study investigated the occurrence, abundance, size, color, and polymer composition of microplastics in surface water, marine sediments, and t...

Liquid chromatography–hydrogen/deuterium exchange–mass spectrometry (LC-HDX-MS) provides orthogonal structural information that complements conventional LC-MS and improves confidence in small-molecule structural elucidation. Although HDX-...

During forest exploitation, large amounts of wood biomass are left as residues after harvesting, even though this material could be valuable in reducing greenhouse gas emissions by replacing fossil fuels and serving as a source of bioactive compounds...

Mercury contamination in aquatic environments poses significant risks to ecosystems and human health, underscoring the need for effective remediation technologies. This research examines the physicochemical properties of the synthesised polymer mater...

Supercritical carbon dioxide extraction (SFE-CO₂) is an efficient and environmentally friendly process for extracting bioactive compounds from plant material. This investigation examined the combined effects of air-drying temperature of the leaves an...

Reliable determination of macro- and micronutrients in cereal plant tissues is essential for agronomic management, environmental monitoring, and interlaboratory data comparability. However, most existing plant certified reference materials (CRMs) are...

The evaluation of analytical methods has evolved beyond traditional validation parameters to encompass environmental sustainability, analytical reliability, and practical applicability. While numerous assessment tools exist for individual dimensions,...

Urinary urea is a key biomarker for tracking protein oxidation and nitrogen balance. A persistent analytical limitation is that conventional total-nitrogen assays do not deconvolute urinary urea from urinary ammonia, and direct measurement still requ...

Metabolomic aging clocks—quantitative models that estimate biological age based on small-molecule profiles in biological fluids—have become dynamic tools for assessing individual aging trajectories and predicting the risk of age-related d...

Sulfated polysaccharides from red algae are multifunctional hydrocolloids whose properties depend strongly on molecular structure, sulfate content, and chain conformation. In this study, a sulfated galactan extracted from Gracilaria vermiculophylla c...

Serum albumin binding plays a critical role in determining the pharmacokinetic and pharmacodynamic behavior of many drugs. Despite extensive studies on human and bovine serum albumin, quantitative binding data for rabbit serum albumin remain limited...

Synthetic azo dyes may be fraudulently added to paprika powder to intensify color, creating a need for rapid, at-line screening before confirmatory chromatographic analysis. This study evaluated handheld laser-induced breakdown spectroscopy (LIBS) fo...

Candida spp. can cause systemic infections with high mortality in immunocompromised patients. Phytotherapy may be an alternative for adjunctive treatment of fungal infections. This study evaluated the phytochemical profile, cytotoxicity, genotoxicity...

This study developed and validated a modified QuEChERS extraction procedure for the determination of 32 pesticide residues in tea (Camellia sinensis) found in Moroccan market originating from China and rosemary (Salvia rosmarinus) leaves using UPLC-M...

The utilisation of cosmetic plant waxes as sustainable functional ingredients in personal care formulations is on the rise. This is due to their emollient, structuring and film-forming properties. Nevertheless, the intricate lipid composition of thes...

This article describes the development of a compact and affordable variable-temperature NMR instrument designed primarily to measure dynamic molecular motion in solids and liquids. The instrument consists of Lab-Tools’ Mk4 palm-top time-domain...

Spectrophotometry offers the advantage of low cost and less time consumption, making it still attractive as a method of analysis, especially when coupled with multivariate calibration models. This enhancement solves the majority of the drawbacks of U...

Oxalic acid is extensively used in industrial chemical processes, purification systems, hydrometallurgical operations, and advanced oxidation environments where rapid and environmentally sustainable analytical methodologies are increasingly required...

Hot-melt extrusion (HME) is widely used in pharmaceutical manufacturing; however, reliable analytical tools are required to simultaneously monitor drug content and excipient stability under thermal processing. In this study, a selective and robust HP...

The chemical composition and bioactivities of dry methanol extracts from roots, leaves and fruits of Prangos trifida (Apiaceae), collected in Serbia, were investigated. LC-DAD-QTOF-MS/MS analysis revealed 30 compounds, primarily polyphenols and couma...

The separation of chiral compounds is a challenging issue in various fields, e.g., biochemistry, the pharmaceutical industry, food chemistry, forensics, agriculture, etc. Very often, one of the two enantiomers can exhibit different activity. Therefor...

The paper describes the preparation of silver-containing nanocomposites by thermolysis of silver cinnamate and their application for the manufacture of reactive indicator paper (RIP) sensitive to iodine. The composition, structure, and properties of...

Despite its widespread use in pharmaceuticals, cosmetics, and animal nutrition, the environmental implications of nicotinamide remain largely underexplored. Given its high solubility and prevalent presence in wastewaters, nicotinamide has been propos...

Comparative interpretation of antioxidant activity across complex natural-product extracts and multi-component formulations is often limited by heterogeneous endpoints, assay-specific reporting, and incompatible units. In this study, we establish a d...

Arachidonate 5-lipoxygenase (ALOX5) is a key enzyme implicated in several inflammatory disorders, including asthma and allergic rhinitis. Despite its therapeutic importance, only one compound is currently approved as an ALOX5 inhibitor in the United...

This paper describes a simple and sensitive method for determining the content of five bisphenols at the µg L⁻¹ level in tea infusion samples. The procedure uses a polypropylene hollow fiber filled with a deep eutectic solvent as the acce...

We studied experimentally and computationally the structures and optical properties of sulfur (S), selenium (Se) and tellurium (Te) ring clusters. We encapsulated S, Se and Te into AFI, MOR, CHA and LTA zeolites via vapor adsorption or high-pressure...

The species Psychotria densicostata Müll.Arg. is a shrub belonging to the Rubiaceae family, endemic to Brazil. So far, there are reports neither of phytochemical work on nor of biological evaluation of it. This study investigated its alkaloid pr...

The herbal tea industry has experienced substantial growth, particularly regarding green tea (Camellia sinensis). In the manufacturing of filter tea, fine herbal dust is generated as a residual by-product during grinding and sieving and is typically...

C₁₃-Norisoprenoids are important contributors to the aroma of Riesling wine. Their quantification is analytically challenging due to their low concentrations, the lack of commercial standards and their pronounced sensitivity to analytical conditions,...

A quartz crystal microbalance-based biosensor for the specific detection of the first transgenic common bean (L.) cultivar (BRS FC401 RMD) with resistance to Bean golden mosaic virus (BGMV) was developed. The immobilization chemistry relies on the st...

Secondary electrospray ionization mass spectrometry (SESI-MS) has emerged as a powerful technique for the real-time, non-invasive analysis of volatile organic compounds (VOCs) in complex matrices, such as exhaled breath and microbial volatilomes. How...

Natural deep eutectic solvents (NADES) offer sustainable alternatives to conventional solvents for plant extraction, yet their influence on extract composition and bioactivity preservation requires further study. Here, choline chloride-based NADES wi...

Phosphonyl tyrosine is one of the main biomarkers to confirm exposure to highly lethal organophosphorus nerve agents (OPNAs) in vivo. However, a critical challenge remains unresolved: ionization suppression occurs during the analysis of phosphonyl ty...

Impurity profiling is of significant analytical and regulatory importance, particularly in the context of lifecycle quality management. A robust chaotropic chromatography method was developed for the determination of olanzapine and its two oxidative...

Light-sensitive protecting chemical groups play an important role in the control of chemical reactions with high spatial and temporal resolution. Various forms of o-nitrobenzyl as a protecting compound are used for light-directed DNA synthesis. The s...

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a powerful technique for polymer identification because it can ionize intact macromolecules with large molecular weights (>100 kDa) and detect them over...

The forensic reliability of biological fluids in sexual assault investigations depends on substrate type, environmental exposure, time since deposition, and analytical methodology. This systematic review evaluates the forensic reliability of major bi...

Objectives: Using high-performance liquid chromatography (HPLC), we developed and validated an in vitro assay for the quantitative determination of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) activity, supplementing limited current...

White Analytical Chemistry (WAC) provides a holistic framework for evaluating analytical methods by balancing analytical performance, environmental sustainability, and practical efficiency. Existing WAC assessment tools offer structured evaluation bu...