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Toxics, Volume 8, Issue 4

December 2020 - 49 articles

Cover Story: Epidemiological studies have linked exposure to ambient particulate matter with gastrointestinal diseases. Ultrafine particles (UFP) are the redox-active sub-fraction of PM2.5, harboring elemental and polycyclic aromatic hydrocarbons from urban environmental sources including diesel and gasoline exhausts. The gut vascular barrier (GVB) regulates paracellular trafficking and systemic disseminations of ingested microbes and toxins. While acute UFP exposure increases both colonic epithelial and endothelial permeability in vitro, the molecular cues whereby UFP ingestion disrupts the embryonic GVB remain elusive. Here, we sought to integrate a genetically tractable embryonic zebrafish system with micro-gavage and optical imaging techniques to visualize disruption of GVB, hoping to unravel epigenetic and genetic cues underlying UFP-mediated disruption of the GVB for therapeutic implications. View this paper
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Articles (49)

  • Article
  • Open Access
38 Citations
5,310 Views
13 Pages

21 December 2020

The movement away from mammalian testing of potential toxicants and new chemical entities has primarily led to cell line testing and protein-based assays. However, these assays may not yet be sufficient to properly characterize the toxic potential of...

  • Article
  • Open Access
30 Citations
5,693 Views
11 Pages

20 December 2020

Confounding adjustment is important for observational studies to derive valid effect estimates for inference. Despite the theoretical advancement of confounding selection procedure, it is often challenging to distinguish between confounders and media...

  • Article
  • Open Access
27 Citations
6,783 Views
13 Pages

Bird Feces as Indicators of Metal Pollution: Pitfalls and Solutions

  • Tapio Eeva,
  • Nelli Raivikko,
  • Silvia Espín,
  • Pablo Sánchez-Virosta,
  • Suvi Ruuskanen,
  • Jouni Sorvari and
  • Miia Rainio

18 December 2020

Bird feces are commonly used as a proxy for measuring dietary metal exposure levels in wild populations. Our study aims to improve the reliability and repeatability of fecal metal measurements and gives some recommendations for sampling. First, we st...

  • Article
  • Open Access
7 Citations
2,841 Views
15 Pages

Influence of Glyphosate Formulations on the Behavior of Sulfentrazone in Soil in Mixed Applications

  • Ana Cláudia Langaro,
  • Matheus de Freitas Souza,
  • Gustavo Antônio Mendes Pereira,
  • João Pedro Ambrósio Barros,
  • Antonio Alberto da Silva,
  • Daniel Valadão Silva,
  • Ana Beatriz Rocha de Jesus Passos and
  • Vander Mendonça

17 December 2020

The selection of weed biotypes that are resistant to glyphosate has increased the demand for its use mixed with other herbicides, such as sulfentrazone. However, when chemical molecules are mixed, interactions may occur, modifying the behavior of the...

  • Article
  • Open Access
10 Citations
4,032 Views
10 Pages

Evaluation of the Skin Sensitization Potential of Carbon Nanotubes Using Alternative In Vitro and In Vivo Assays

  • Sung-Hyun Kim,
  • Dong Han Lee,
  • Jin Hee Lee,
  • Jun-Young Yang,
  • Hyo-Sook Shin,
  • JeongPyo Lee,
  • Kikyung Jung,
  • Jayoung Jeong,
  • Jae-Ho Oh and
  • Jong Kwon Lee

16 December 2020

Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in indiv...

  • Review
  • Open Access
76 Citations
9,297 Views
20 Pages

Radon—The Element of Risk. The Impact of Radon Exposure on Human Health

  • Anna Grzywa-Celińska,
  • Adam Krusiński,
  • Jadwiga Mazur,
  • Katarzyna Szewczyk and
  • Krzysztof Kozak

14 December 2020

Lung cancer is a heterogeneous group of diseases with multifactorial aetiology. Smoking has been undeniably recognized as the main aetiological factor in lung cancer, but it should be emphasized that it is not the only factor. It is worth noting that...

  • Article
  • Open Access
9 Citations
3,608 Views
14 Pages

14 December 2020

Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) represents a stringent priority nowadays. Carbon disulfide (CS2) is such a chemical, being widely used in manufacturing synthetic textile fibers and as a solvent. C...

  • Communication
  • Open Access
9 Citations
4,109 Views
9 Pages

13 December 2020

Glycidyl fatty acid esters (GE) are constituents of edible oils and fats, and are converted into glycidol, a genotoxic substance, in vivo. N-(2,3-dihydroxypropyl)valine (diHOPrVal), a hemoglobin adduct of glycidol, is used as a biomarker of glycidol...

  • Review
  • Open Access
38 Citations
4,963 Views
22 Pages

Not Only Toxic but Repellent: What Can Organisms’ Responses Tell Us about Contamination and What Are the Ecological Consequences When They Flee from an Environment?

  • Cristiano V. M. Araújo,
  • Abdelmourhit Laissaoui,
  • Daniel C. V. R. Silva,
  • Eloisa Ramos-Rodríguez,
  • Enrique González-Ortegón,
  • Evaldo L. G. Espíndola,
  • Francisco Baldó,
  • Freylan Mena,
  • Gema Parra and
  • Julián Blasco
  • + 5 authors

12 December 2020

The ability of aquatic organisms to sense the surrounding environment chemically and interpret such signals correctly is crucial for their ecological niche and survival. Although it is an oversimplification of the ecological interactions, we could co...

  • Article
  • Open Access
4 Citations
3,040 Views
14 Pages

Chironomus riparius Proteome Responses to Spinosad Exposure

  • Hugo R. Monteiro,
  • João L. T. Pestana,
  • Amadeu M. V. M. Soares,
  • Bart Devreese and
  • Marco F. L. Lemos

11 December 2020

The potential of proteome responses as early-warning indicators of insecticide exposure was evaluated using the non-biting midge Chironomus riparius (Meigen) as the model organism. Chironomus riparius larvae were exposed to environmentally relevant c...

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Toxics - ISSN 2305-6304Creative Common CC BY license