Special Issue "Fish Models for Human Toxicology"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Dr. Demetrio Raldúa
E-Mail Website
Guest Editor
Department Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18, 08034 Barcelona, Spain
Interests: fish neurotoxicology; zebrafish model; fish developmental neurotoxicology
Special Issues and Collections in MDPI journals
Dr. Benjamin Piña
Guest Editor
Institute of Environmental Assessment and Water Research, IDAEA-CSIC, Barcelona, Catalunya 08034, Spain
Interests: ecotoxicology; molecular biology; biochemistry; omics
Dr. Natalia Garcia-Reyero
Guest Editor
Environmental Laboratory, US Army Engineer Research & Development Center, Vicksburg, MS 39180, USA
Interests: toxicogenomics; predictive toxicology; zebrafis; adverse outcome pathways

Special Issue Information

Dear Colleagues,

Whereas many of the human toxidromes have already been modelized in rodents, only a few models have been developed and conveniently validated in fish. Before proposing the use of any fish model of human toxidromes, the validity of the developed model should always be tested. Thus, an intensive effort should be made to characterize the effects of the toxicant at different levels of biological organization, from molecular to behavioral, in the developed model as a part of the validation process. As fish are considered a less-sentient organism, even adult fish models of human toxidromes fully meet the 3Rs principles. This advantage makes fish ideal for the initial screening and prioritization of chemicals providing protection against the toxidromes, as only the most promising drugs would be further validated in a rodent model. This approach makes it possible to obtain highly predictive results for humans, because if one drug provides protection against a neurotoxic in both fish and rodents (two phylogenetically distant vertebrate models), it is likely working through highly conserved mechanisms, and there is thus a high probability that it will also be useful in protecting humans against the same toxidrome.

This Special Issue on “Fish Models for Human Toxicology” aims to highlight the research into the development and validation of human toxidromes using well-established fish models in biomedicine, such as zebrafish or medaka. We are also interested in studies using fish models to increase our current mechanistic understanding of human toxidromes, identifying new potential therapeutic targets and developing more effective therapies.

Authors are invited and welcome to submit original research papers, reviews, and short communications.

Dr. Demetrio Raldúa
Dr. Benjamin Piña
Dr. Natalia Garcia-Reyero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • fish models
  • toxicology
  • adverse outcome pathways
  • treatment
  • validity process
  • mechanistic approach

Published Papers (1 paper)

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Open AccessArticle
Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects
Toxics 2020, 8(4), 103; https://doi.org/10.3390/toxics8040103 - 13 Nov 2020
Viewed by 638
Safe endocrine-disrupting alternatives for bisphenol A (BPA) are needed because its adverse health effects have become a public concern. Some bisphenol analogues (bisphenol F and S) have been applied, but their endocrine-disrupting potential is either not negligible or weaker than that of BPA. [...] Read more.
Safe endocrine-disrupting alternatives for bisphenol A (BPA) are needed because its adverse health effects have become a public concern. Some bisphenol analogues (bisphenol F and S) have been applied, but their endocrine-disrupting potential is either not negligible or weaker than that of BPA. However, the endocrine-disrupting potential of bisphenol AP (BPAP), another BPA alternative, has not yet been fully assessed. Hence, we evaluated the thyroid hormone (TH)-disrupting potency of BPAP because THs are essential endocrine hormones. Zebrafish embryos were exposed to BPAP (0, 18.2, 43.4, or 105.9 μg/L) for 120 h, and TH levels, the transcription of 16 TH-related genes, the transcriptome, development, and behavior were evaluated. In our study, a decrease in T4 level was observed only at the maximum nonlethal concentration, but significant changes in the T3 and TSHβ levels were not detected. BPAP did not cause significant changes in transcription and gene ontology enrichment related to the TH system. Developmental and behavioral changes were not observed. Despite T4 level reduction, other markers were not significantly affected by BPAP. These might indicate that BPAP has weak or negligible potency regarding TH disruption as a BPA alternative. This study might provide novel information on the TH-disrupting potential of BPAP. Full article
(This article belongs to the Special Issue Fish Models for Human Toxicology)
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