Special Issue "Fish Models for Human Toxicology"
Deadline for manuscript submissions: 31 August 2021.
Interests: fish neurotoxicology; zebrafish model; fish developmental neurotoxicology
Special Issues and Collections in MDPI journals
Interests: ecotoxicology; molecular biology; biochemistry; omics
Interests: toxicogenomics; predictive toxicology; zebrafis; adverse outcome pathways
Whereas many of the human toxidromes have already been modelized in rodents, only a few models have been developed and conveniently validated in fish. Before proposing the use of any fish model of human toxidromes, the validity of the developed model should always be tested. Thus, an intensive effort should be made to characterize the effects of the toxicant at different levels of biological organization, from molecular to behavioral, in the developed model as a part of the validation process. As fish are considered a less-sentient organism, even adult fish models of human toxidromes fully meet the 3Rs principles. This advantage makes fish ideal for the initial screening and prioritization of chemicals providing protection against the toxidromes, as only the most promising drugs would be further validated in a rodent model. This approach makes it possible to obtain highly predictive results for humans, because if one drug provides protection against a neurotoxic in both fish and rodents (two phylogenetically distant vertebrate models), it is likely working through highly conserved mechanisms, and there is thus a high probability that it will also be useful in protecting humans against the same toxidrome.
This Special Issue on “Fish Models for Human Toxicology” aims to highlight the research into the development and validation of human toxidromes using well-established fish models in biomedicine, such as zebrafish or medaka. We are also interested in studies using fish models to increase our current mechanistic understanding of human toxidromes, identifying new potential therapeutic targets and developing more effective therapies.
Authors are invited and welcome to submit original research papers, reviews, and short communications.
Dr. Demetrio Raldúa
Dr. Benjamin Piña
Dr. Natalia Garcia-Reyero
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- fish models
- adverse outcome pathways
- validity process
- mechanistic approach