Special Issue "Persistent Organic Pollutants and Human Health"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editor

Dr. Luis Alberto Henríquez-Hernández
Guest Editor
Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain
Interests: environmental toxicology; biomonitoring; persistent organic pollutant; heavy metals; emerging pollutants; pesticides; mechanisms of action of pollutants

Special Issue Information

Dear colleagues,

Persistent organic pollutants (POPs) are a group of substances characterized by their high resistance to environmental degradation, their lipophilic nature, and their ability to alter physiological systems of living beings, specifically the endocrine systems. They are substances which were used as pesticides (organochlorine pesticides like DDT), as flame retardants (polychlorinated biphenyls (PCBs) or polybromodiphenyl ethers (PBDEs)), and they have other uses mainly associated to the industry (dioxins). Due to their potential damage to the environment and people, most of these substances were included in different annexes of the Stockholm Convention and banned, mostly, for decades. Despite this, biomonitoring studies show that the world’s population still has detectable levels of many of these substances. In addition, it has been seen that persistent organic pollutants are associated with different human diseases, including cancer, cardiovascular diseases or diabetes. Moreover, many of these compounds seem to alter fat metabolism and be partially responsible for the obesity epidemic that plagues the planet. It is a topic of total relevance which affects humans as a species and the total environment of the planet and that, therefore, still requires continuous research to answer the many questions that are not clarified.

Dr. Luis Alberto Henríquez-Hernández
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • persistent organic pollutants
  • xenobiotics
  • endocrine disruptors
  • organochlorine pesticides
  • polychlorinated biphenyls (PCBs)
  • polybromodiphenyl ethers (PBDEs)
  • dioxins
  • biomonitoring
  • human health

Published Papers (1 paper)

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Open AccessArticle
Lactational Transfer of Long-Chain Perfluorinated Carboxylic Acids in Mice: A Method to Directly Collect Milk and Evaluate Chemical Transferability
Toxics 2020, 8(2), 23; https://doi.org/10.3390/toxics8020023 - 01 Apr 2020
Perfluoroalkyl carboxylic acids (PFCAs), such as perfluorooctanoic acid (PFOA, C8), are a group of industrial chemicals that are detected in the serum of people throughout the world. Long-chain PFCAs (C9 to C13) have high lipophilicity, therefore they may have a high transfer rate [...] Read more.
Perfluoroalkyl carboxylic acids (PFCAs), such as perfluorooctanoic acid (PFOA, C8), are a group of industrial chemicals that are detected in the serum of people throughout the world. Long-chain PFCAs (C9 to C13) have high lipophilicity, therefore they may have a high transfer rate to breast milk. This study investigated the lactational transfer of PFCAs with carbon chain lengths of 8 to 13 in mice. Lactating dams were given a single intravenous administration of PFCAs (C8 to C13) during the postnatal period (8–13 days after delivery). Milk was collected from the dam 24 h after administration using a milking device built in-house. Plasma was obtained from the dam at the same time as milk collection. The observed milk/plasma (M/P) concentration ratios were 0.32 for C8, 0.30 for C9, 0.17 for C10, 0.21 for C11, 0.32 for C12, and 0.49 for C13. These results indicate that the M/P concentration ratio is not related to the lipophilicity of PFCAs. However, estimated relative daily intake, an indicator of how much PFCA is transferred from dams to pups per body weight, increased with chain length: 4.16 for C8, 8.98 for C9, 9.35 for C10, 9.51 for C11, 10.20 for C12, and 10.49 for C13, which may be related to the lower clearance of long-chain PFCAs. These results indicate the importance of future risk assessment of long-chain PFCAs. Full article
(This article belongs to the Special Issue Persistent Organic Pollutants and Human Health)
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