You are currently viewing a new version of our website. To view the old version click .

Separations, Volume 12, Issue 6

June 2025 - 33 articles

Cover Story: The development of chromatographic processes to purify biopharmaceuticals requires tremendous experimental effort. The state-of-the-art approach, Design of Experiments, enables a systematic procedure limited to a design space described by a statistical, interpolating model; however, the experimental burden remains high. Process development would benefit from extrapolating models to reduce this burden and enable deeper process understanding and knowledge transfer. Nevertheless, such models currently lack predictive power. In an academic–industrial collaboration, we present a new biophysics-based adsorption model for developing ion-exchange chromatography processes for pharmaceuticals at a preparative scale. This model achieves high predictive power across low and high antibody load densities and even captures charge variant behavior. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (33)

  • Article
  • Open Access
907 Views
22 Pages

This study presents a cost-effective and feasible technique for the deep denitrification of wastewater, based on sulfur autotrophic denitrification mediated by polysulfides (Sn2−). Various polysulfides were used as electron donors in an aerobic...

  • Article
  • Open Access
948 Views
21 Pages

Green Extraction Combined with Chemometric Approach: Profiling Phytochemicals and Antioxidant Properties of Ten Species of the Lamiaceae Family

  • Branislava Teofilović,
  • Emilia Gligorić,
  • Martina Ninić,
  • Saša Vukmirović,
  • Žarko Gagić,
  • Nebojša Mandić-Kovačević,
  • Biljana Tubić,
  • Đorđe Đukanović and
  • Nevena Grujić-Letić

The pharmacological potential of Lamiaceae plants is primarily linked to their high content of phenolic acids and flavonoids, known for strong antioxidant properties. This study investigated the antioxidant activity of ten widely used Lamiaceae herbs...

  • Review
  • Open Access
1 Citations
3,824 Views
26 Pages

Antimony Recovery from Industrial Residues—Emphasis on Leaching: A Review

  • Marinela Panayotova,
  • Serhii Pysmennyi and
  • Vladko Panayotov

Antimony (Sb) is a metalloid widely used in different areas—from the cutting-edge renewable energy technologies to “classical” lead acid batteries. Its availability in primary sources is limited, and these sources are geographically...

  • Article
  • Open Access
1 Citations
959 Views
13 Pages

The unregulated consumption of corticosteroids causes significant adverse effects on human health. Therefore, it is important to develop methodologies that allow their analysis in pharmaceutical matrices with competitive analysis times and costs. The...

  • Article
  • Open Access
648 Views
11 Pages

Hydrothermal conversion is an effective strategy to transform heavy metals in electroplating sludge into catalytic materials and use them to treat electroplating wastewater. This study presents a one-step hydrothermal method for converting Sn-bearing...

  • Article
  • Open Access
953 Views
20 Pages

The efficient separation of light hydrocarbons, particularly alkanes from their isomers (C5–C6), represents a significant and energy-intensive challenge for the petrochemical industry. Metal-Organic Frameworks (MOFs) offer promising solutions d...

  • Article
  • Open Access
2 Citations
804 Views
14 Pages

Physicochemical and Phytochemical Determinations of Greek “Kollitsida’’ (Arctium lappa L.) from Different Regions and Evaluation of Its Antimicrobial Activity

  • Dimitrios G. Lazaridis,
  • Sokratis D. Giannoulis,
  • Maria Simoni,
  • Vassilios K. Karabagias,
  • Nikolaos D. Andritsos,
  • Vasileios Triantafyllidis and
  • Ioannis K. Karabagias

The present study aimed to investigate Greek Kollitsida root samples from different geographical regions based on physicochemical and antibacterial analyses. For this purpose, samples were treated with different solvents, deionized water (solvent A)...

  • Article
  • Open Access
2 Citations
1,490 Views
19 Pages

The hydrocyclone generally exhibits limited separation efficiency and classification sharpness. As the discharge channel for fine particles, the vortex finder plays a critical role in influencing the classification performance through its structural...

  • Review
  • Open Access
2 Citations
3,960 Views
19 Pages

As sustainability gains prominence, the circular economy has encouraged the valorization of agri-food by-products, which are rich in phenolic compounds known for their antioxidant and anti-inflammatory properties. Conventional extraction methods comm...

  • Article
  • Open Access
2 Citations
2,143 Views
20 Pages

Effective Liquid–Liquid Extraction for the Recovery of Grape Pomace Polyphenols from Natural Deep Eutectic Solvents (NaDES)

  • Alessandro Frontini,
  • Giulio Tarentini,
  • Carmine Negro,
  • Andrea Luvisi,
  • Massimiliano Apollonio and
  • Luigi De Bellis

Natural deep eutectic solvents (NaDESs) are emerging solvents for their yield when used for extraction of different molecules, including polyphenols. NaDESs are a cutting-edge technology that offers numerous advantages, including cheap cost, safety,...

of 4

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Separations - ISSN 2297-8739