Skip to Content
You are currently on the new version of our website. Access the old version .

Separations, Volume 12, Issue 7

2025 July - 20 articles

Cover Story: Gallic acid defines much of a wine’s character—from flavor and color to health benefits. Accurately quantifying it, however, remains an important analytical challenge. We introduce a new GC-MS method that streamlines this process. At its core is a one-pot ethyl chloroformate (ECF) derivatization, optimized using a Box–Behnken Design. This statistical approach revealed the complex interplay among ECF, ethanol, and pyridine, enabling the identification of their optimal concentrations to enhance reaction efficiency. The method demonstrated excellent linearity, precision, and sensitivity. It was successfully applied to a wide range of commercial wines, capturing the natural variability of gallic acid levels across different styles. This derivatization strategy offers a practical and reliable tool for routine enological analysis. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (20)

  • Article
  • Open Access
3 Citations
2,108 Views
21 Pages

Natural Deep Eutectic Solvent-Based Extraction of Malva sylvestris L.: Phytochemical Content, Antioxidant and Antimicrobial Potential

  • Neli Memdueva,
  • Milena Tzanova,
  • Zvezdelina Yaneva,
  • Nikolina Rusenova,
  • Neli Grozeva and
  • Toncho Dinev

Malva sylvestris L. is a herbaceous plant, distributed worldwide, rich in biological active compounds, and known for its health benefits. In this study, extracts from different parts (leaves, flowers, and roots) of this plant were prepared using gree...

  • Article
  • Open Access
699 Views
11 Pages

Application of the Precolumn Derivatization Reagent CIM-C2-NH2 for Labeling Carboxyl Groups in LC-MS/MS Analysis of Primary Organic Acids in Japanese Sake

  • Mayu Onozato,
  • Haruna Uchida,
  • Misaki Ono,
  • Mikoto Koishi,
  • Maya Oi,
  • Maho Umino,
  • Tatsuya Sakamoto and
  • Takeshi Fukushima

Japanese sake, a traditional alcoholic beverage, contains several organic acids that may contribute to its sour taste. To identify these, a precolumn derivatization reagent, benzyl 5-(2-aminoethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (CIM-C2-NH...

  • Review
  • Open Access
8 Citations
4,869 Views
19 Pages

Nanoplastics: From Separations to Analysis—Challenges and Limitations

  • Justyna Ośko,
  • Kornelia Kadac-Czapska,
  • Katarzyna Jażdżewska,
  • Natalia Nowak,
  • Piotr Kowalczyk and
  • Małgorzata Grembecka

The issue of nanoplastics (NPs) in the environment, following that of microplastics (MPs), is receiving increasing attention in the scientific community. Due to their size, these particles require the development and application of new methods for bo...

  • Article
  • Open Access
736 Views
13 Pages

This paper presents a numerical investigation into the generation of 2D ordered pillar array columns for liquid chromatography columns, focusing on the development of an algorithm for the automatic creation of unit-cell morphologies and their subsequ...

  • Article
  • Open Access
3 Citations
1,139 Views
16 Pages

Optimized Ethyl Chloroformate Derivatization Using a Box–Behnken Design for Gas Chromatography–Mass Spectrometry Quantification of Gallic Acid in Wine

  • Sofia Botta,
  • Roberta Piacentini,
  • Chiara Cappelletti,
  • Alessio Incocciati,
  • Alberto Boffi,
  • Alessandra Bonamore and
  • Alberto Macone

Gallic acid, a major phenolic compound in wine, significantly influences its sensory profile and health-related properties, making its accurate measurement essential for both enological and nutritional studies. In this context, a derivatization proto...

  • Review
  • Open Access
4 Citations
4,063 Views
22 Pages

Impact of Use of Ultrasound-Assisted Extraction on the Quality of Brazil Nut Oil (Bertholletia excelsa HBK)

  • Orquidea Vasconcelos dos Santos,
  • Sara Camila Vidal Freires,
  • Helen Cristina de Oliveira Palheta and
  • Paulo Henrique de Melo Ferreira

The quality of materials extracted from plant sources, such as oilseeds, is significantly affected by the extraction techniques employed. Thermo-photosensitive bioactive compounds are especially susceptible, often resulting in a loss of functional pr...

  • Article
  • Open Access
1 Citations
957 Views
12 Pages

This study centers on the adsorption–flotation coupling extraction of rubidium (Rb+) and cesium (Cs+) within a titanium silicate (CTS)–cetyltrimethylammonium bromide (CTAB) system, systematically investigating the impacts of pH, aeration...

  • Review
  • Open Access
1 Citations
1,821 Views
26 Pages

Advances in Electrolytic Manganese Residue: Harmless Treatment and Comprehensive Utilization

  • Weijian Yu,
  • Xiaoya Li,
  • Wenting Xu,
  • Qingjun Guan,
  • Fujia Zhou,
  • Jiani Zhang,
  • Li Wang,
  • Yanxiu Wang and
  • Honghu Tang

Electrolytic manganese residue (EMR) is a byproduct of electrolytic manganese production, rich in soluble pollutants such as manganese and ammonia nitrogen. Traditional stockpiling methods result in contaminant leaching and water pollution, threateni...

  • Article
  • Open Access
3 Citations
2,092 Views
14 Pages

The widespread use of plastics in our daily life has caused many health problems. Conventional water treatment processes have low efficiency in the removal of microplastics from water. In this work, we investigated the efficiency of ozonation pretrea...

  • Article
  • Open Access
1 Citations
925 Views
12 Pages

The conventional spent lithium-ion batteries (LIBs) recycling method suffers from complex processes and excessive chemical consumption. Hence, this study proposes an electrochemical strategy for achieving reductant-free leaching of high-valence trans...

  • Article
  • Open Access
1 Citations
1,185 Views
15 Pages

Thermodynamic Characteristics of the Ion-Exchange Process Involving REMs of the Light Group

  • Olga V. Cheremisina,
  • Maria A. Ponomareva,
  • Yulia A. Mashukova,
  • Nina A. Nasonova and
  • Maria D. Burtseva

Rare earth metals (REMs) are vital for high-tech industries, but their extraction from secondary sources is challenging due to environmental and technical constraints. This study investigates the ion-exchange extraction of light REMs (neodymium, pras...

  • Article
  • Open Access
1 Citations
1,393 Views
18 Pages

Background: Method quantification limits are typically determined by measuring variability at blank level only, without accounting for the uncertainties associated with the parameters of the calibration function applied. Methods: A method for the det...

  • Article
  • Open Access
4 Citations
1,897 Views
13 Pages

Heracleum sosnowskyi Manden. (Sosnowsky’s hogweed), originally introduced to Central and Eastern Europe as a fodder crop, has become a highly invasive species due to its ecological adaptability, high reproductive capacity, and efficient seed di...

  • Article
  • Open Access
1,168 Views
15 Pages

Heterogeneous Interactions During Bubble–Oil Droplet Contact in Water

  • Tao Yang,
  • Hao Xiao,
  • Chunyu Jiang,
  • Ming Ma,
  • Guangwen Zhang,
  • Chun Wang,
  • Yi Zheng and
  • Xiangdi Zhao

Oily wastewater is extensively generated during the petroleum extraction and refining processes, as crude oil production water and from the effluent systems in petrochemical enterprises. The discharge standards for such wastewater are stringent, with...

  • Article
  • Open Access
1 Citations
1,335 Views
13 Pages

To address severe ammonia gas and dust pollution coupled with resource waste in exhaust gases from urea prilling towers, a production process for gasified biochar-based slow-release fertilizer is proposed to achieve resource recovery of exhaust pollu...

  • Article
  • Open Access
1 Citations
980 Views
22 Pages

Sponge-like Modified White-Rot Fungi Adsorbent for Rapid Removal of Pb(II) and Cd(II) from Solution: Selective Performance and Mechanistic Insights

  • Chunxiao Wang,
  • Zhirong Chen,
  • Nana Wang,
  • Jianqiao Wang,
  • Runshen He,
  • Yu Chen,
  • Haerfosai Nuhu,
  • Hang Chen,
  • Zhixuan Lin and
  • Mingdong Chang
  • + 1 author

Heavy metal pollution, especially from Pb(II) and Cd(II), poses significant risks due to its persistence and bioaccumulation potential. Traditional removal methods face challenges like high costs and secondary pollution. This study developed a novel...

  • Article
  • Open Access
2,164 Views
13 Pages

Trans fatty acids (TFAs) pose significant health risks, including cardiovascular disease and metabolic disorders. However, the lack of high-resolution, high-sensitivity, and high-throughput quantitative methods for TFA analysis has led to fragmented...

  • Article
  • Open Access
2,177 Views
20 Pages

Extraction of Terpenoids from Pine Needle Biomass Using Dimethyl Ether

  • Gary S. Groenewold,
  • Christopher Orme,
  • Caleb Stetson,
  • Rebecca M. Brown,
  • Lynn M. Wendt and
  • Aaron D. Wilson

Pine needles are an industrial feedstock for extracts used in a variety of applications, but conventional extraction methods often result in a degradation of the terpenoid compounds that naturally occur in loblolly pine (Pinus taeda). Separation of t...

  • Article
  • Open Access
1 Citations
1,177 Views
15 Pages

This study investigates the compositional characteristics and quantitative differences of ginsenosides across various ginseng tissues, with a particular focus on the specific accumulation patterns of malonyl ginsenosides. Five tissue samples—gi...

  • Article
  • Open Access
1,921 Views
11 Pages

Content Determination and Impurity Profiling of Compound Glycyrrhizin Tablets by Ion-Pair High-Performance Liquid Chromatography, Coupled with Corona-Charged Aerosol Detector

  • Limin Zuo,
  • Wenling Su,
  • Yongsheng Gu,
  • Xiaodan Qiu,
  • Ting Zhao,
  • Xiaofang Lian,
  • Huiyi Liu,
  • Qingying Jia,
  • Ruifang Zheng and
  • Guangzhi Shan

Compound Glycyrrhizin tablets (CGTs) are a combination of glycyrrhizin, glycine and methionine. Glycine and methionine have relatively high polarity and lack chromophore; therefore, it is difficult to simultaneously determine the various components u...

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Separations - ISSN 2297-8739