2026 October - 162 articles
Cuticular wax covers the epidermal surface of bread wheat (Triticum aestivum L.) and plays a key role in regulating wheat environmental adaptation. Elucidating the molecular mechanism underlying cuticular wax biosynthesis could facilitate wheat genet...
Platelet surface adhesion receptors and intracellular signaling proteins have been the focus of platelet research for decades, with the aim of understanding how they contribute to hemostatic and thrombotic functions. However, membrane transporters an...
Interleukin-15 (IL-15) is an immunoregulatory cytokine also recognized as a myokine, with experimentally demonstrated cytoprotective and metabolic effects. Renal tubular epithelial cells (TECs) and podocytes express components of the IL-15 receptor s...
RNA 3′-end modification is an important regulatory mechanism that influences RNA processing, stability, localization, function, and degradation. Beyond its biological roles, RNA 3′-end modification has become a valuable tool in biotechnol...
Dimethyl sulfoxide (DMSO) is a polar aprotic solvent used in biomedical research, pharmaceutical formulation, some clinical applications, and cryopreservation. Here we review molecular activity related to DMSO and selected clinical applications inclu...
Objective: To explore the mechanism by which Schizophyllum commune elevates dendrobine accumulation in Dendrobium nobile, and verify whether cellulase derived from this fungus triggers jasmonate biosynthesis to mediate the regulation of alkaloid prod...
Vitamin D–Vitamin D receptor (VDR) signaling extends beyond calcium-phosphate homeostasis and regulates immune tolerance, inflammation, cellular differentiation, oxidative stress, and endocrine physiology. This systematic review evaluated the r...
ANGPTL3 and PCSK9 are key regulators of lipoprotein metabolism, with emerging evidence suggestive of a functional regulatory interrelationship. Indeed, patients lacking ANGPTL3 due to loss-of-function variants exhibit reduced circulating PCSK9 levels...
Retinol, a vitamin A derivative belonging to the retinoid family, is widely recognized for its anti-aging and wound-healing properties. In this study, we investigated the effects of retinol on the production of growth factors and major extracellular...
Spleen tyrosine kinase is a non-receptor tyrosine kinase that couples receptor engagement to cellular survival, immune responses, and tissue injury. This narrative review compares its biology in malignancies and sepsis to examine how cellular compart...
Genomic DNA is constantly exposed to endogenous and exogenous stresses that can cause different types of DNA damage. DNA double-strand breaks (DSBs) are among the most damaging forms of DNA lesions, as persistent breaks can compromise genome stabilit...
Skeletal muscle aging is a conserved biological process characterized by progressive declines in muscle mass, strength, regenerative capacity, and metabolic adaptability, contributing to impaired mobility, frailty and age-related diseases. Beyond its...
Flavonoids exhibit many proven health benefits and play critical roles in preventing, delaying, or even reversing chronic disease conditions. The biological activities of flavonoids strongly depend on their structures, and they interact with many bio...
Connective tissue disease-associated interstitial lung disease (CTD-ILD) is one of the most severe pulmonary complications of connective tissue diseases, featuring rapid progression and heterogeneous prognosis. Early recognition and prognostic predic...
Multiple sclerosis (MS) is a chronic immune-mediated disease for which non-invasive biomarkers, able to detect disease- and treatment-associated molecular changes, are needed. We characterized the whole-saliva proteome of patients with relapsing-remi...
Background/Objectives: Phage display relies on the physical linkage between the antibody fragment displayed on a virion (phenotype) and the phagemid encoding it (genotype), allowing antigen-binding clones enriched by bio-panning to be identified by s...
Hierarchical organization transpires within a tumor. It is appreciated that cancer stem cells (CSCs) are the cornerstone primary cells of such assemblies, fueled by molecular mechanisms that allow resistance to chemotherapy, vigorous self-renewal cap...
Bone homeostasis depends on coordinated activity among bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts. Disruption of this cellular network contributes to osteoporosis, impaired fracture repair, and other skeletal disorde...
Scorpion toxin peptides are useful bioactive substance resources, but no anticomplement peptides have been reported from scorpions. Here, we attempt to explore scorpion-derived anticomplement peptides by scanning a small and specific scorpion toxin p...
Over the past few decades, advances in comparative pathology have strengthened the potential translational value of animal models of Idiopathic Pulmonary Fibrosis (IPF). The integration of human-relevant diagnostic biomarkers into preclinical studies...
Background: Identifying novel, reliable blood-based biomarkers is essential to better assess disease activity in idiopathic inflammatory myopathies (IIMs). We aimed to determine serum fatty acid binding protein 3 (FABP3) levels in IIM patients and ev...
Oncogenic Ras signaling drives cell growth and tumor progression through acquired changes in gene expression that promote the malignant phenotype. One such gene, SERPINE1, which encodes plasminogen activator inhibitor-1 (PAI-1), is a poor prognostic...
Bacterial lipopolysaccharide (LPS) disrupts endothelial barrier stability by inducing inflammatory events that underlie acute lung injury (ALI). Effective pharmacologic therapies capable of modifying the disease mechanisms of ALI remain limited. We p...
Theranostic imaging agents combine molecular diagnosis, targeted therapy and monitoring of treatment response into a single paradigm of precision medicine. This review summarizes the current development and translational landscape of theranostic imag...
Normozoospermia, defined by semen parameters above the WHO lower reference limits, is conventionally treated as a single category. Increasing evidence suggests that this classification may encompass molecular heterogeneity. This pilot-pooled sequenci...
In recent years, a growing interest in plant-based medicine has been observed, mainly due to a wide variety of secondary plant compounds and their health-promoting properties. Multiple health-supporting qualities have been described, but much remains...
Chronic liver disease represents a substantial global health burden, yet effective anti-fibrotic therapies remain elusive, largely due to an incomplete understanding of extracellular matrix (ECM) remodeling. While historical research prioritized the...
Limb-girdle muscular dystrophy R6, formerly LGMD2F, is caused by mutations in the δ-sarcoglycan (Sgcd) gene and is characterized by progressive skeletal muscle degeneration. Although loss of δ-SG protein compromises sarcolemma stability,...
Background: Pulmonary endothelial cells are increasingly recognized as active regulators of organ-specific metastasis; however, the mechanisms by which they influence melanoma invasion remain incompletely understood. Methods: Six primary melanoma-der...
Photoacoustic imaging is a noninvasive imaging modality with considerable potential for theranostic applications, providing high-resolution visualization of molecular and physiological responses to treatment. Among the diverse materials investigated...
Geranium glaberrimum Boiss. & Heldr. is a Turkish endemic species with previously reported phytochemical and biological properties; however, comparative phytochemical and antioxidant data across different plant organs remain scarce. In this study...
Litter size is a critical trait determining the economic efficiency of sheep production. Ferritin heavy chain 1 (FTH1), a key iron-storage protein, plays an important role in regulating cellular susceptibility to ferroptosis. Based on our previous ob...
Cardiovascular diseases remain the leading cause of mortality worldwide and continue to impose a substantial clinical burden despite major advances in pharmacological and interventional therapies. Because the adult myocardium has limited regenerative...
Androgenetic alopecia (AGA) is the most prevalent form of hair loss, yet current therapies offer limited efficacy and fail to restore the disrupted follicular immune microenvironment. Here, we developed a bioactive hydrogel microneedle system (P-MN)...
Aging is a multidimensional biological process that is not adequately captured by chronological age alone. Geroscience—the study of biological mechanisms that drive age-related functional decline and disease susceptibility—therefore requi...
MicroRNAs (miRNAs) are involved in the regulation of glucose metabolism and inflammatory processes associated with type 2 diabetes (T2D) and have potential as biomarkers and therapeutic targets. We analysed the expression of miR-155-5p, miR-141-3p, m...
Chemotherapy-induced peripheral neuropathy (CIPN) combines abnormal sensory firing with neuronal and axonal injury. This critical narrative review focuses on selected voltage-gated sodium, calcium, and Kv7 potassium channels and transient receptor po...
Air pollution, particularly particulate matter (PM), is a major contributor to cardiovascular morbidity and mortality. We previously showed that diesel exhaust particles (DEPs) exposure increases arrhythmia susceptibility in rats, associated with myo...
Heme promotes oxidative modification of low-density lipoprotein (LDL), a process implicated in atherosclerosis. However, the fate of heme during LDL oxidation and the mechanisms governing its degradation remain poorly understood. We investigated heme...
The ovarian lymphatic vasculature has emerged as a potential regulator of ovarian function, yet its role in follicular development remains poorly defined. Here, we aimed to elucidate the dynamic changes in ovarian lymphatic vessels during follicular...
Type 1 diabetes (T1D) is driven by immune-mediated destruction and dysfunction of pancreatic β-cells, with autoreactive CD8+ T cells serving as important effectors of β-cell injury. T-cell immunoglobulin and mucin domain-containing protein...
Animal bile has been used for millennia in traditional Chinese medicine as a cough suppressant and bronchodilator. As the primary functional constituents of bile, bile acids (BAs) are believed to mediate these physiological effects. Although the role...
Excitotoxicity mediated by the α-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid receptor (AMPAR) is a major contributor to neuronal degeneration and inflammation in various neurological disorders. The endocannabinoid system (ECS), specifica...
Alzheimer’s disease (AD) is a neurodegenerative disorder involving multiple pathological processes, including amyloid-β (Aβ) accumulation, tau pathology, impaired autophagy, mitochondrial dysfunction, neuroinflammation, and synaptic d...
Ischemia-reperfusion injury (IRI) determines early and delayed graft function and long-term allograft survival in solid organ transplantation and is one determinant of outcome that remains modifiable in the operating room. Cell-free heme, a Danger-As...
Despite advances in pharmaceutical and technological development, cancer continues to be a life-threatening illness globally. In addition to other specialized procedures, radiotherapy, chemotherapy, and surgery are methods used to treat cancer. Howev...
Pancreatic ductal adenocarcinoma (PDAC) is rarely detected before the disease is advanced, and existing serum markers are insufficient for early detection. Its systemic immune alterations are incompletely characterized and rarely examined by sex. We...
The palliative and anti-cancer properties of CBD are attracting increasing attention. We have examined the dose-dependent effects of CBD on the viability and antitumor properties of human NK cells. CBD killed NK cells with an apparent IC50 of 77 μ...
Edaravone (EDA) is a synthetic free-radical scavenger FDA-approved for amyotrophic lateral sclerosis (ALS) treatment in the United States and is used clinically for treatment of acute ischemic stroke in Japan and other countries. While its antioxidan...
The plant cell wall functions as both a mechanical framework and a dynamic environmental sensor, with its remodeling tightly coordinated by phytohormone signaling and cell-wall integrity (CWI) surveillance. This review synthesizes how hormonal networ...
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