Oxidative Stress, DNA Integrity, and Environmental Toxicity in Reproductive and Metabolic Health

Topic Information

Dear Colleagues,

Functional disorders in cells and organisms may arise from endogenous alterations in gene regulation, metabolism, and cellular signaling, as well as from exposure to environmental toxicants, pharmaceuticals, endocrine disruptors, and other xenobiotics. These perturbations can disrupt cellular homeostasis through oxidative stress, DNA damage, impaired repair mechanisms, mitochondrial dysfunction, and epigenetic alterations, ultimately compromising reproductive competence, metabolic balance, fertility, and organismal health.

This Topic welcomes original research articles, reviews, and methodological studies addressing the molecular mechanisms linking environmental and pharmacological exposures to reproductive and metabolic dysfunction. Areas of interest include reproductive stem cell biology, gametogenesis, gamete quality, fertilization, embryonic development, reproductive metabolism, endocrine regulation, tissue homeostasis, infertility, and transgenerational effects.

We particularly encourage studies integrating experimental evidence with in silico, computational, and artificial intelligence-based approaches. Relevant methods include bioinformatics, systems biology, multi-omics integration, machine learning, molecular docking, protein–protein and protein–ligand interaction analysis, protein–DNA/RNA interaction studies, homology modeling, molecular dynamics simulations, network pharmacology, cheminformatics, computational toxicology, and QM/QM-MM investigations. Contributions combining cellular, biochemical, omics, structural, computational, and AI-assisted analyses are especially welcome.

Dr. Carmen Di Giovanni
Dr. Xiaoning Zhang
Prof. Dr. Antonio Lavecchia
Prof. Dr. Marina Piscopo
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	8.2	14.7	2012	18.7 Days	CHF 2900	Submit
Biology biology	4.3	7.3	2012	14.2 Days	CHF 2700	Submit
Biomedicines biomedicines	4.5	7.8	2013	18.2 Days	CHF 2600	Submit
Biomolecules biomolecules	5.6	9.3	2011	16.6 Days	CHF 2700	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Journal of Xenobiotics jox	4.6	5.1	2011	14.9 Days	CHF 1600	Submit
Metabolites metabolites	4.5	8.1	2011	12.6 Days	CHF 2700	Submit
Toxics toxics	4.9	7.8	2013	17 Days	CHF 2600	Submit

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Published Papers