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Biology, Volume 10, Issue 4

April 2021 - 98 articles

Cover Story: Genome organization shapes the “traffic patterns" of transcriptional regulators. The DNA-binding protein, CCCTC-binding factor (CTCF) and the ring-shaped cohesin complex, regulate the three-dimensional (3D) organization of the genome by establishing chromatin loops that form topologically associating domains (TADs) and sub-TADs. To make DNA accessible or inaccessible to these players, ATP-dependent chromatin remodelers are likely required to mobilize the nucleosomes; however, studies elucidating the intersection between chromatin remodeling and 3D genome organization are only just emerging. This review highlights established and potential roles for specific remodelers in regulating various aspects of CTCF/cohesin-mediated genome organization. View this paper.
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Articles (98)

  • Article
  • Open Access
19 Citations
7,069 Views
12 Pages

16 April 2021

The aim of this study is to assess the efficiency of psyllium husk ethanolic extract (PHEE) on Triton X-100 induced hyperlipidemic rats by studying the changes in hepatic and pancreatic function and histopathology. Forty male albino rats (bodyweight...

  • Review
  • Open Access
37 Citations
14,870 Views
27 Pages

Macronutrient Determinants of Obesity, Insulin Resistance and Metabolic Health

  • Jibran A. Wali,
  • Samantha M. Solon-Biet,
  • Therese Freire and
  • Amanda E. Brandon

16 April 2021

Obesity caused by the overconsumption of calories has increased to epidemic proportions. Insulin resistance is often associated with an increased adiposity and is a precipitating factor in the development of cardiovascular disease, type 2 diabetes, a...

  • Article
  • Open Access
26 Citations
11,844 Views
24 Pages

Biochemical Characterization of the Amylase Activity from the New Haloarchaeal Strain Haloarcula sp. HS Isolated in the Odiel Marshlands

  • Patricia Gómez-Villegas,
  • Javier Vigara,
  • Luis Romero,
  • Cecilia Gotor,
  • Sara Raposo,
  • Brígida Gonçalves and
  • Rosa Léon

16 April 2021

Alpha-amylases are a large family of α,1-4-endo-glycosyl hydrolases distributed in all kingdoms of life. The need for poly-extremotolerant amylases encouraged their search in extreme environments, where archaea become ideal candidates to provide new...

  • Article
  • Open Access
2 Citations
3,214 Views
12 Pages

Integration of Multiple Resolution Data in 3D Chromatin Reconstruction Using ChromStruct

  • Claudia Caudai,
  • Monica Zoppè,
  • Anna Tonazzini,
  • Ivan Merelli and
  • Emanuele Salerno

16 April 2021

The three-dimensional structure of chromatin in the cellular nucleus carries important information that is connected to physiological and pathological correlates and dysfunctional cell behaviour. As direct observation is not feasible at present, on o...

  • Article
  • Open Access
60 Citations
8,857 Views
16 Pages

Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan

  • Yi-Wei Chen,
  • Yi-Yen Lee,
  • Chun-Fu Lin,
  • Po-Shen Pan,
  • Jen-Kun Chen,
  • Chun-Wei Wang,
  • Shih-Ming Hsu,
  • Yu-Cheng Kuo,
  • Tien-Li Lan and
  • Sanford P. C. Hsu
  • + 25 authors

15 April 2021

Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. We performed BNCT on 34 patie...

  • Article
  • Open Access
7 Citations
3,211 Views
16 Pages

15 April 2021

Actinic keratosis (AK) is the ultra violet (UV)-induced preneoplastic skin lesion clinically classified in low (KIN I), intermediate (KIN II), and high (KIN III) grade lesions. In this work we analyzed the expression of Fibroblast Growth Factor Recep...

  • Article
  • Open Access
11 Citations
3,158 Views
17 Pages

15 April 2021

The glycogen synthase kinase 3β (GSK-3β) is a protein kinase involved in regulating numerous physiological processes such as embryonic development, transcription, insulin action, cell division cycle and multiple neuronal functions. The overexpression...

  • Article
  • Open Access
5 Citations
3,105 Views
11 Pages

Mechanisms of Venoarteriolar Reflex in Type 2 Diabetes with or without Peripheral Neuropathy

  • Cécile Reynès,
  • Antonia Perez-Martin,
  • Houda Ennaifer,
  • Henrique Silva,
  • Yannick Knapp and
  • Agnès Vinet

15 April 2021

The aim of this study is to investigate the underlying mechanisms of the venoarteriolar reflex (VAR) in type 2 diabetes mellitus (T2DM), with and without peripheral neuropathy. Laser Doppler flowmetry (LDF) recordings were performed on the medial mal...

  • Article
  • Open Access
6 Citations
2,655 Views
11 Pages

Benefits of Local Treatment Including External Radiotherapy for Hepatocellular Carcinoma with Portal Invasion

  • Han Ah Lee,
  • Sunmin Park,
  • Yeon Seok Seo,
  • Won Sup Yoon,
  • Chai Hong Rim and
  • on behalf of the Korean Liver Cancer Study Group

14 April 2021

We aimed to identify the oncologic benefits of local treatment including radiotherapy (LRT) in hepatocellular carcinoma (HCC) invading the portal vein. We used clinical data of patients with HCC invading the portal vein from 2008 to 2014 provided by...

  • Article
  • Open Access
9 Citations
4,634 Views
14 Pages

Oxygen Dependence of Flight Performance in Ageing Drosophila melanogaster

  • Valeriya Privalova,
  • Ewa Szlachcic,
  • Łukasz Sobczyk,
  • Natalia Szabla and
  • Marcin Czarnoleski

14 April 2021

Similar to humans, insects lose their physical and physiological capacities with age, which makes them a convenient study system for human ageing. Although insects have an efficient oxygen-transport system, we know little about how their flight capac...

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Biology - ISSN 2079-7737