You are currently viewing a new version of our website. To view the old version click .

Journal of Clinical Medicine, Volume 14, Issue 21

November-1 2025 - 441 articles

Cover Story: Few therapeutic options meaningfully improve symptomatology plus quality of life (QoL) in Parkinson’s disease (PD), emphasising the need for novel, evidence-based interventions. This study evaluated the efficacy of photobiomodulation therapy (PBMt) combined with exercise on motor and non-motor outcomes in PD. Sixty-three participants were first enrolled in an 8-week randomised, sham-controlled stage with a 4-week washout, followed by a crossover to all active treatments with a 4-week washout, then an optional extended treatment of up to 48 weeks. Moderate–vigorous exercise was maintained. Extended PBMt yielded significant improvements in timed up and go (TUG), anxiety, and MDS-UPDRS II, with UPDRS total and other outcome measures approaching significance. This supports its potential as a safe, scalable, home-based adjunct to standard PD management. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (441)

  • Review
  • Open Access
1,207 Views
21 Pages

6 November 2025

Background: Medial-compartment knee osteoarthritis with varus alignment is treated surgically by realignment (high tibial osteotomy, HTO), resurfacing (unicompartmental knee arthroplasty, UKA), or proximal fibular osteotomy (PFO), which aims to indir...

  • Systematic Review
  • Open Access
823 Views
15 Pages

Management of Recurrent Temporomandibular Joint Dislocation in Children: A Systematic Review

  • Amelia Hoppe,
  • Natalia Turosz,
  • Maciej Chęciński,
  • Kamila Chęcińska,
  • Klaudia Kwiatkowska,
  • Kalina Romańczyk,
  • Adam Michcik,
  • Barbara Wojciechowska,
  • Tomasz Wach and
  • Maciej Sikora

6 November 2025

Background/Objectives: Children’s unique physiological and behavioral needs require individualized treatment planning. It seems reasonable to investigate treatment options for recurrent temporomandibular joint (TMJ) dislocation and assess their...

  • Article
  • Open Access
433 Views
13 Pages

Minimally Invasive Treatment of Three-Part Proximal Humerus Fractures: A Two-Center Comparative Study of Plate Fixation and Intramedullary Nailing

  • Calogero Puma Pagliarello,
  • Vito Pavone,
  • Fabrizio Quattrini,
  • Pietro Maniscalco,
  • Virginia Masoni and
  • Corrado Ciatti

6 November 2025

Background/Objectives: Proximal humerus fractures account for approximately 5% of all skeletal injuries, and their optimal surgical management remains debated. The optimal fixation method for three-part proximal humerus fractures remains a matter of...

  • Article
  • Open Access
438 Views
10 Pages

Transient Osteoporosis of the Hip: Clinical and Radiological Outcomes After Combined Pharmacologic and Biophysical Therapy

  • Calogero Puma Pagliarello,
  • Vito Pavone,
  • Antonio Kory,
  • Luciano Costarella,
  • Antonio Buscema,
  • Gianluca Testa and
  • Corrado Ciatti

6 November 2025

Introduction: Transient osteoporosis of the hip (TOH) is a rare, self-limiting disorder characterized by acute hip pain and reversible osteopenia. The aim of this study was to evaluate clinical outcomes following treatment with Neridronate, Clodronic...

  • Article
  • Open Access
338 Views
14 Pages

6 November 2025

Background/Objectives: We aimed to determine the prevalence of bipolar disorder (BD) in a Spanish disabled adult population (DAP), the differences in sociodemographic and clinical variables in the DAP with and without BD, and the factors associated w...

  • Article
  • Open Access
405 Views
10 Pages

Type I Interferon-Related Gene Expression and Laboratory Abnormalities in Acute Infection Are Associated with Long COVID Symptom Burden

  • Mary Emmanouil,
  • Vasiliki E. Georgakopoulou,
  • Konstantinos Drougkas,
  • Panagiotis Lembessis,
  • Charalampos Skarlis,
  • Aikaterini Gkoufa,
  • Nikolaos V. Sipsas and
  • Clio P. Mavragani

6 November 2025

Background: Long COVID—defined as the persistence of symptoms or the development of new symptoms beyond four weeks after acute SARS-CoV-2 infection—affects an estimated 10–30% of individuals recovering from COVID-19, posing a signif...

  • Article
  • Open Access
496 Views
16 Pages

Bruxism Simulation in Aligner Therapy: Effects on Restored Posterior Teeth

  • Amelia Anita Boitor (Andreica),
  • Adriana Objelean,
  • Cristina Gasparik,
  • Alexandru Victor Burde,
  • Horațiu Alexandru Colosi and
  • Diana Dudea

6 November 2025

Background/Objectives: Parafunctional habits such as bruxism generate high occlusal forces that can significantly compromise the performance of dental restorations during orthodontic treatment. This ex vivo study aimed to evaluate the surface wear of...

  • Article
  • Open Access
432 Views
13 Pages

Hearing Preservation and Complications of the Middle Cranial Fossa Approach for Otolaryngological Diseases: Twelve-Year Single-Center Experience

  • Toshihito Sahara,
  • Takeshi Fujita,
  • Yujiro Hoshi,
  • Hajime Koyama,
  • Anjin Mori,
  • Yasuhiro Osaki,
  • Akinori Kashio,
  • Yasuhiro Sanada and
  • Katsumi Doi

6 November 2025

Objectives: The middle cranial fossa (MCF) approach is valued for preserving hearing while accessing the internal auditory canal (IAC), petrous apex, inner ear, and related structures. This study evaluated its clinical outcomes across otolaryngologic...

  • Review
  • Open Access
469 Views
15 Pages

6 November 2025

Obesity is a significant risk factor for cardiovascular diseases. Although previous studies have shown uncertainty about its role in aortic dissection (AD), our clinical observations showed that most younger patients with acute AD have a significantl...

  • Article
  • Open Access
545 Views
17 Pages

Multiple-Site Lichen Planus: An Italian Case Series of 44 Patients

  • Federico Bardazzi,
  • Lidia Sacchelli,
  • Giacomo Clarizio,
  • Federica Filippi,
  • Camilla Loi and
  • Michelangelo La Placa

6 November 2025

Background: Lichen planus (LP) is a chronic immune-mediated inflammatory disorder affecting skin, mucosae, nails, and appendages, often with significant impact on quality of life. While associations between oral LP (OLP) and other localizations have...

of 45

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
J. Clin. Med. - ISSN 2077-0383