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Vaccines, Volume 13, Issue 12

2025 December - 82 articles

Cover Story: This review outlines a coherent framework for the design of the next generation of mRNA cancer vaccines. We examine how modifications spanning nucleosides, UTRs, poly(A) tails, codon usage, and linker sequences—together with lipid nanoparticle formulation—collectively shape protein expression, innate immune sensing, and antigen presentation. By linking these molecular design choices to corse principles of tumor immunology, we show how translation efficiency, immune activation, and antigen presentation can be systematically used. When integrated with advances in neoantigen prediction and immune monitoring, these insights provide a blueprint for the development of next-generation mRNA-based cancer therapies. View this paper
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Vaccines - ISSN 2076-393X
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