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Vaccines, Volume 13, Issue 12

December 2025 - 82 articles

Cover Story: This review outlines a coherent framework for the design of the next generation of mRNA cancer vaccines. We examine how modifications spanning nucleosides, UTRs, poly(A) tails, codon usage, and linker sequences—together with lipid nanoparticle formulation—collectively shape protein expression, innate immune sensing, and antigen presentation. By linking these molecular design choices to corse principles of tumor immunology, we show how translation efficiency, immune activation, and antigen presentation can be systematically used. When integrated with advances in neoantigen prediction and immune monitoring, these insights provide a blueprint for the development of next-generation mRNA-based cancer therapies. View this paper
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Articles (82)

  • Article
  • Open Access
335 Views
19 Pages

Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice

  • Felicity C. Stark,
  • Bassel Akache,
  • Tyler M. Renner,
  • Gerard Agbayani,
  • Lise Deschatelets,
  • Renu Dudani,
  • Blair A. Harrison,
  • Usha D. Hemraz,
  • Sophie Régnier and
  • Matthew Stuible
  • + 2 authors

18 December 2025

Background/Objectives: The rise of immune escape variants of the SARS-CoV-2 virus has prompted the development of vaccines based on the variant’s spike antigen sequence. Since variant-specific SARS-CoV-2 vaccines are mostly administered as boos...

  • Article
  • Open Access
464 Views
12 Pages

18 December 2025

Background: Childhood immunization is one of the most effective public health strategies for reducing morbidity and mortality from vaccine-preventable diseases. Although overall vaccination coverage in the United States remains high, disparities pers...

  • Article
  • Open Access
635 Views
16 Pages

18 December 2025

Background: Socioeconomic disparities may affect COVID-19 booster vaccination uptake, potentially undermining public health efforts. This study assessed the association between first booster dose coverage and municipal socioeconomic deprivation in th...

  • Review
  • Open Access
474 Views
24 Pages

Competing Theories on Global and Regional Vaccine Inequities: A Scoping Literature Review Within the Context of the COVID-19 Pandemic

  • Karl Philipp Puchner,
  • Elias Kondilis,
  • Nasia Palantza,
  • Stergios Seretis,
  • Stavros Mavroudeas,
  • Alexis Benos and
  • Dimitris Papamichail

17 December 2025

Background/Objectives: Despite global efforts, COVID-19 revealed severe spatial vaccine inequities, disproportionately affecting low- and middle-income countries (LMICs). Scholars across disciplines proposed numerous—and often competing—t...

  • Article
  • Open Access
459 Views
15 Pages

Booster Vaccination Against Invasive Pneumococcal Disease and Hepatitis B in Previously Vaccinated Solid Organ Transplant Recipients Without Seroprotection

  • Julie Sejerøe-Olsen,
  • Moises Alberto Suarez-Zdunek,
  • Thomas Helbo,
  • Lise Bank Hornung,
  • Charlotte Sværke Jørgensen,
  • Kasper Rossing,
  • Michael Perch,
  • Allan Rasmussen,
  • Sebastian Rask Hamm and
  • Susanne Dam Nielsen

17 December 2025

Background: Despite pre-transplantation vaccination against invasive pneumococcal disease (IPD) and hepatitis B virus (HBV), most solid organ transplant (SOT) recipients are without post-transplantation seroprotection against IPD and HBV. We aimed to...

  • Article
  • Open Access
525 Views
16 Pages

Seasonal Influenza Vaccination Uptake and Intentions Among Nursing Students in Hong Kong

  • Maria Shuk Yu Hung,
  • Grace Sun King Wan,
  • Wai Hon Chua and
  • Ching Man Cheng

17 December 2025

Background/Objectives: Seasonal influenza is a global public health issue, and influenza vaccination is the most effective preventive measure. Nursing students are at a higher risk of contracting it due to clinical exposure. However, vaccination upta...

  • Editorial
  • Open Access
487 Views
4 Pages

17 December 2025

The global response to SARS-CoV-2 has advanced at unprecedented speed: vaccines developed in record time, mass immunization campaigns, and real-world data confirming reductions in severe disease and death [...]

  • Article
  • Open Access
415 Views
21 Pages

Retrospective Cohort Analysis of Survival After SARS-CoV-2 Infection by Vaccination Status in Jamaica, April–December 2021

  • Karen Webster-Kerr,
  • Andriene Grant,
  • Ardene Harris,
  • Eon Campbell,
  • Deborah Henningham,
  • Marsha Brown,
  • Daidre Rowe,
  • Carol Lord,
  • Romae Thorpe and
  • Tanielle Mullings
  • + 4 authors

17 December 2025

Background/Objectives: To estimate (a) survival after SARS-CoV-2 infection by COVID-19 vaccination status, and (b) COVID-19 vaccine effectiveness in a middle-income country. Methods: In this retrospective cohort study, secondary analysis of data from...

  • Article
  • Open Access
495 Views
12 Pages

16 December 2025

Background: Influenza presents significant risks to older adults; however, vaccination coverage in China remains low despite robust recommendations. Factors such as vaccine hesitancy, physician recommendations, health status, and socioeconomic condit...

  • Article
  • Open Access
588 Views
18 Pages

Vaccine Platform-Dependent Differential Impact on Microbiome Diversity: Potential Advantages of Protein Subunit Vaccines

  • Hye Seong,
  • Jin Gu Yoon,
  • Eliel Nham,
  • Yu Jung Choi,
  • Ji Yun Noh,
  • Hee Jin Cheong,
  • Woo Joo Kim,
  • Sooyeon Lim and
  • Joon Young Song

15 December 2025

Background: The COVID-19 pandemic accelerated the development of diverse vaccine platforms, including mRNA, adenoviral vector, and protein subunit vaccines. Given the growing evidence that the gut microbiome modulates vaccine-induced immunity, this s...

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Vaccines - ISSN 2076-393X