- Article
Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity
- Abdelnaser A. Badawy,
- Rasha Elghaba,
- Mohamed Soliman,
- Abdelaziz M. Hussein,
- Sana A. AlSadrah,
- Amira Awadalla and
- Osama A. Abulseoud
Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH4) remains under investigation. Male Sprague Dawle...

