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Open AccessArticle

Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old

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IRCCS Istituto delle Scienze Neurologiche di Bologna, Diagnostica Funzionale Neuroradiologica, Ospedale Bellaria di Bologna, 40139 Bologna, Italy
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Dipartimento di Medicina Specialistica Diagnostica e Sperimentale (DIMES), Università di Bologna, 40126 Bologna, Italy
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IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuroradiologia, Ospedale Bellaria di Bologna, 40139 Bologna, Italy
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IRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Ospedale Bellaria di Bologna, 40139 Bologna, Italy
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Dipartimento di Scienze Biomediche e Neuromotorie (DIBINEM), Università di Bologna, 40126 Bologna, Italy
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Dipartimento di Farmacia e Biotecnologie, Università di Bologna, 40126 Bologna, Italy
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Authors to whom correspondence should be addressed.
Brain Sci. 2020, 10(10), 741; https://doi.org/10.3390/brainsci10100741
Received: 20 August 2020 / Revised: 11 October 2020 / Accepted: 13 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Recent Advances in Neurodevelopmental Disorders)
We examined the potential benefits of neuroimaging measurements across the first 5 years of life in detecting early comorbid or etiological signs of autism spectrum disorder (ASD). In particular, we analyzed the prevalence of neuroradiologic findings in routine magnetic resonance imaging (MRI) scans of a group of 117 ASD children younger than 5 years old. These data were compared to those reported in typically developing (TD) children. MRI findings in children with ASD were analyzed in relation to their cognitive level, severity of autistic symptoms, and the presence of electroencephalogram (EEG) abnormalities. The MRI was rated abnormal in 55% of children with ASD with a significant prevalence in the high-functioning subgroup compared to TD children. We report significant incidental findings of mega cisterna magna, ventricular anomalies and abnormal white matter signal intensity in ASD without significant associations between these MRI findings and EEG features. Based on these results we discuss the role that brain MRI may play in the diagnostic procedure of ASD. View Full-Text
Keywords: magnetic resonance imaging; autism spectrum disorder; incidental findings; neurobiology magnetic resonance imaging; autism spectrum disorder; incidental findings; neurobiology
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MDPI and ACS Style

Rochat, M.J.; Distefano, G.; Maffei, M.; Toni, F.; Posar, A.; Scaduto, M.C.; Resca, F.; Cameli, C.; Bacchelli, E.; Maestrini, E.; Visconti, P. Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old. Brain Sci. 2020, 10, 741. https://doi.org/10.3390/brainsci10100741

AMA Style

Rochat MJ, Distefano G, Maffei M, Toni F, Posar A, Scaduto MC, Resca F, Cameli C, Bacchelli E, Maestrini E, Visconti P. Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old. Brain Sciences. 2020; 10(10):741. https://doi.org/10.3390/brainsci10100741

Chicago/Turabian Style

Rochat, Magali J.; Distefano, Giacomo; Maffei, Monica; Toni, Francesco; Posar, Annio; Scaduto, Maria C.; Resca, Federica; Cameli, Cinzia; Bacchelli, Elena; Maestrini, Elena; Visconti, Paola. 2020. "Brain Magnetic Resonance Findings in 117 Children with Autism Spectrum Disorder under 5 Years Old" Brain Sci. 10, no. 10: 741. https://doi.org/10.3390/brainsci10100741

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