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Diagnostics, Volume 15, Issue 23

December-1 2025 - 15 articles

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Articles (15)

  • Article
  • Open Access
Diagnostics2025, 15(23), 2951;https://doi.org/10.3390/diagnostics15232951 
(registering DOI)

21 November 2025

Background/Objectives: This study demonstrates improved generalization in pressure-ulcer stage classification. In medical imaging, training data are often scarce and disease specific. For skin conditions such as pressure ulcers, variation in camera t...

  • Article
  • Open Access
Diagnostics2025, 15(23), 2950;https://doi.org/10.3390/diagnostics15232950 
(registering DOI)

21 November 2025

Background: Lynch syndrome (LS) is a cancer-susceptibility syndrome associated with autosomal dominant predisposition to a spectrum of cancers, primarily of the colorectum and endometrium, which exhibit impaired DNA mismatch repair (MMR) activity. LS...

  • Article
  • Open Access

21 November 2025

Background/Objectives: Some classification problems involve ordered categories (e.g., low–medium–high), which are better modeled as ordinal regression. This study aimed to propose and evaluate a dual loss framework—Ordinal Residual...

  • Article
  • Open Access

Machine Learning-Based Algorithm for Tacrolimus Dose Optimization in Hospitalized Kidney Transplant Patients

  • Dong Jin Park,
  • Mihyeong Kim,
  • Hyungjin Cho,
  • Jung Soo Kim,
  • Jeongkye Hwang and
  • Jehoon Lee

21 November 2025

Background: Tacrolimus is a cornerstone immunosuppressant in kidney transplantation, but its narrow therapeutic index and marked inter-patient variability complicate dose optimization. Conventional therapeutic drug monitoring (TDM) relies on empirica...

  • Article
  • Open Access

21 November 2025

Background/Objectives: Infectious gastroenteritis (IGE) is a major global health concern due to its high morbidity and healthcare burden. The BioFire FilmArray Gastrointestinal Panel (FA-GIP) enables rapid multiplex detection of enteric pathogens, of...

  • Article
  • Open Access

TNF-α Quantification in Formalin-Fixed Paraffin-Embedded Tissues as a Predictive Biomarker in Ulcerative Colitis

  • Anna Viola,
  • Walter Giuseppe Giordano,
  • Rasmus Goll,
  • Emanuela Germanà,
  • Vincenzo Fiorentino,
  • Valeria Zuccalà,
  • Gabriele Ricciardi,
  • Mariagiovanna Ballato,
  • Pietro Tralongo and
  • Antonio Ieni
  • + 4 authors

21 November 2025

Objectives: Anti-TNF-α therapies have transformed the management of Inflammatory Bowel Disease (IBD), yet a substantial proportion of patients fail to respond, highlighting the urgent need for predictive biomarkers. Mucosal TNF-α mRNA qua...

  • Article
  • Open Access

21 November 2025

Background: Rapid molecular detection of antimicrobial resistance (AMR) can shorten time to effective therapy in complicated urinary tract infections (cUTI), but the ability of gene presence and quantitative PCR signal (Ct, and ΔCt = Ct_marker...

  • Review
  • Open Access

Next-Generation Sequencing for Bloodstream Infections: Shaping the Future of Rapid Diagnostics and Precision Medicine

  • Ayman Elbehiry,
  • Eman Marzouk,
  • Husam M. Edrees,
  • Moustafa H. Abdelsalam,
  • Feras Aljizani,
  • Saad Alqarni,
  • Eyad Khateeb,
  • Feras Alzaben,
  • Mai Ibrahem and
  • Ayman M. Mousa
  • + 2 authors

21 November 2025

Bloodstream infections and sepsis necessitate rapid, sensitive, and clinically relevant diagnostics to minimize treatment delays and improve clinical outcomes. Next-generation sequencing enables culture-independent pathogen detection, antimicrobial r...

  • Article
  • Open Access

Illuminating the Intricacies: A Comparative Cross-Sectional Sonographic Evaluation of Degenerative Changes in Leiomyomas Through Post-Processing Technique

  • Mahasin G. Hassan,
  • Nouf Aldrees,
  • Sadeem Aldawsari,
  • Raghad Alanazi,
  • Noura Alboqami,
  • Maryem Alanazi,
  • Renad Alanazi,
  • Khadejah Alrashidi and
  • Basim S. Almutairi

21 November 2025

Background: Leiomyomas are benign tumors that may cause symptoms and affect fertility, requiring careful assessment. Magnetic Resonance Imaging (MRI) becomes crucial when ultrasonography results are inconclusive; however, it is expensive and time-con...

  • Correction
  • Open Access

Correction: Chen et al. The Efficacy and Safety of Tandem Transplant Versus Single Stem Cell Transplant for Multiple Myeloma Patients: A Systematic Review and Meta-Analysis. Diagnostics 2024, 14, 1030

  • Yu-Han Chen,
  • Lindsay Fogel,
  • Andrea Yue-En Sun,
  • Chieh Yang,
  • Rushin Patel,
  • Wei-Cheng Chang,
  • Po-Huang Chen,
  • Hong-Jie Jhou,
  • Yeu-Chin Chen and
  • Ming-Shen Dai
  • + 1 author

21 November 2025

After publication, the authors identified several errors in the manuscript, including inconsistencies between the manuscript’s reported results and the corresponding figures, a missing citation, and incorrect reference citations [...]

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Diagnostics - ISSN 2075-4418