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Life
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Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment
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Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 309

Special Issue Editors

Prof. Dr. Eliza Elena Cintezǎ

E-Mail Website
Guest Editor
1. Department of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Department of Pediatric Cardiology, “Marie Curie” Emergency Children’s Hospital, 041451 Bucharest, Romania
Interests: congenital heart malformations; echocardiography; multimodal imaging; interventional cardiology; heart surgery; pediatric arrhythmia
Special Issues, Collections and Topics in MDPI journals
Dr. Ştefana Moisǎ

E-Mail Website
Guest Editor
1. Department of Pediatrics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2. “Sfanta Maria” Clinical Emergency Hospital for Children, 700309 Iasi, Romania
Interests: pediatric cardiology; echocardiography; congenital heart diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of pediatric cardiology is advancing at an unprecedented pace, driven by groundbreaking innovations in the diagnosis and treatment of congenital and acquired heart diseases in children. This Special Issue, titled "Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment", aims to provide a comprehensive overview of the latest scientific and clinical advancements that are reshaping the care of pediatric patients with cardiovascular conditions. From cutting-edge imaging technologies, such as 3D echocardiography and fetal cardiac MRI, to the integration of artificial intelligence for risk stratification and early detection, this Special Issue explores how these tools are enabling more precise and personalized care. Minimally invasive interventions, including transcatheter procedures and robotic-assisted surgeries, are also transforming treatment paradigms, offering safer and more effective options for young patients. Additionally, this Special Issue delves into the growing role of genomics, molecular biology, and regenerative medicine in understanding and treating pediatric heart disease.

The scope of this Special Issue encompasses original research articles, reviews, and case studies that highlight emerging trends, challenges, and opportunities in pediatric cardiology. By fostering interdisciplinary collaboration and sharing innovative approaches, this Special Issue seeks to inspire further research, improve clinical practice, and ultimately enhance outcomes for children with cardiovascular conditions worldwide.

Prof. Dr. Eliza Elena Cintezǎ
Dr. Ştefana Moisǎ
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital heart disease
  • cardiovascular imaging
  • minimally invasive interventions
  • fetal cardiology
  • transcatheter therapies
  • artificial intelligence in cardiology
  • 3D echocardiography
  • cardiac MRI
  • personalized medicine
  • genetic heart disorders
  • heart failure in children
  • robotic-assisted surgery
  • cardiovascular biomarkers
  • electrophysiology in pediatrics
  • innovative surgical techniques
  • early diagnosis of heart disease
  • emerging therapies in cardiology

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Published Papers (1 paper)

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Research

13 pages, 532 KiB  
Article
Association of Plasma Renin Activity with Risk of Late Hypertension in Pediatric Patients with Early Aortic Coarctation Repair: A Retrospective Study
by Irina-Maria Margarint, Tammam Youssef, Iulian Rotaru, Alexandru Popescu, Olguta Untaru, Cristina Filip, Ovidiu Stiru, Ancuta-Alina Constantin, Vlad Anton Iliescu and Radu Vladareanu
Life 2025, 15(4), 656; https://doi.org/10.3390/life15040656 - 16 Apr 2025
Viewed by 223
Abstract
Background: Coarctation of the aorta (CoA) represents 5% to 7% of all congenital heart diseases. Surgery and interventional methods offer great short-term results, but the occurrence of postoperative hypertension associated with cardiovascular and cerebral vascular disease increases mortality and morbidity in the long [...] Read more.
Background: Coarctation of the aorta (CoA) represents 5% to 7% of all congenital heart diseases. Surgery and interventional methods offer great short-term results, but the occurrence of postoperative hypertension associated with cardiovascular and cerebral vascular disease increases mortality and morbidity in the long term. This study aims to investigate risk factors associated with postoperative hypertension in pediatric patients with early repair of isolated aortic coarctation. Subjects and Methods: A total of 41 patients with isolated aortic coarctation were included. The mean age was 35.3 ± 46.34 days. Early repair under one month was performed in 65.9% of patients. In all except two patients, end-to-end anastomosis was used. A follow-up at two years revealed an incidence of 58.5% of hypertension. Using logistic regression, preoperative renin plasma concentration above the upper normal level (46.1 μUI/mL) was independently associated with the occurrence of hypertension (OR = 2.49, 95% CI = 2.001–5.03, p = 0.001). Conclusion: Coarctation of the aorta is not just a simple mechanical obstruction of the aorta and should be seen and managed as a systemic disease. Abnormal preoperative renin concentrations were independently associated with the occurrence of HT at follow-up, suggesting that vascular dysfunction could play a role in hypertension development after successful CoA repair, negatively influencing the long-term prognostic of these patients. Full article
(This article belongs to the Special Issue Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment)
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