Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition

Dear Colleagues,

The regulation of oxidative stress plays a fundamental role in several physiological and pathological processes, encompassing the modulation of the inflammatory response, cellular proliferation, apoptotic activity, and immune responses. In addition, its relationship with various diseases has been studied, such as inflammatory bowel diseases (IBDs), cardiovascular and neurodegenerative disorders, cancer, and metabolic syndromes.

Over the past few decades, coordinated solutions have been proposed to remedy these intracellular imbalances. Within this context, bioactive compounds have emerged as pivotal candidates due to changes in scientific perspectives and growing concern within society about understanding the food ecosystem.

The benefits that these bioactive compounds can provide will depend on their redox signalling mechanisms. Many of them possess antioxidant properties and can act as electron donors, neutralizing free radicals and reducing oxidative stress. This helps to ensure the maintenance of a proper redox balance in cells and prevents oxidative damage to biomolecules such as lipids, proteins, and DNA.

These compounds can act as key modulators in regulating cellular processes, which could have a significant impact on health and well-being.

This Special Issue revolves around the search for bioactive compounds and their impact on cellular signalling, unveiling new avenues of action within known signalling pathways. These compounds offer a promising opportunity to prevent the development of neurodegenerative and cardiovascular diseases.

Studying their effect on lifelong disorders provides a deeper understanding of these underlying mechanisms and may lead to the development of innovative therapeutic interventions in the future.

In this sense, several studies are relevant to this Special Issue, including systematic reviews and metanalyses, clinical trials, and preclinical studies. Submitted manuscripts must include sufficiently detailed descriptions of the composition and stability of the study material when addressing plant extracts or other natural compounds.

Dr. Guillermo Cásedas
Dr. Francisco Les
Guest Editors

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