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Life
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Novel Therapeutics for Musculoskeletal Disorders
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Novel Therapeutics for Musculoskeletal Disorders

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 26 March 2026 | Viewed by 491

Special Issue Editors

Dr. Dalila Scaturro

E-Mail Website
Guest Editor
Precision Medicine in the Medical, Surgical and Critical Care Areas, University of Palermo, Palermo, Italy
Interests: osteoarthritis; osteoporosis; bone; arthropathy; joint; pain; low back pain
Prof. Dr. Giulia Letizia Mauro

E-Mail Website
Guest Editor
Precision Medicine in the Medical, Surgical and Critical Care Areas, University of Palermo, Palermo, Italy
Interests: osteoarthritis; osteoporosis; bone; arthropathy; joint; pain; low back pain

Special Issue Information

Dear Colleagues,

Musculoskeletal disorders represent a leading cause of disability globally, significantly affecting people's quality of life and productivity. Despite progress in understanding the pathophysiological basis of these conditions, many conventional therapies prove insufficient in ensuring complete and sustainable recovery.

This Special Issue of Life is dedicated to exploring the latest therapeutic innovations for musculoskeletal disorders, with a focus on multimodal approaches, emerging technologies and personalized strategies. The collected articles offer an overview of new frontiers in treatment, including regenerative medicine, gene therapy, tissue engineering, neuromodulation techniques and the integration of artificial intelligence in diagnosis and rehabilitation.

The goal of this Special Issue is to promote multidisciplinary dialogue between researchers, clinicians and medical technology developers, providing an updated reference point to guide clinical practice and stimulate new research directions.

We thank all the authors and reviewers for their valuable contribution, and we hope that this volume will inspire further progress in the increasingly patient-centered and evidence-based treatment of musculoskeletal disorders.

Dr. Dalila Scaturro
Prof. Dr. Giulia Letizia Mauro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • osteoporosis
  • bone
  • arthropathy
  • joint
  • pain
  • lower back pain

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

12 pages, 548 KiB  
Article
The Role of Postural Assessment, Therapeutic Exercise and Foot Orthoses in Haemophilic Arthropathy: A Pilot Study
by Dalila Scaturro, Sofia Tomasello, Vincenzo Caruso, Isabella Picone, Antonio Ammendolia, Alessandro de Sire and Giulia Letizia Mauro
Life 2025, 15(8), 1217; https://doi.org/10.3390/life15081217 - 1 Aug 2025
Viewed by 359
Abstract
Haemophilic arthropathy is caused by repeated joint bleeding episodes, primarily affecting knees, ankles and elbows. Conservative options should be considered prior to surgery, as well as postural evaluation, since any functional overload promotes the development of new bleeding. The aim of this study [...] Read more.
Haemophilic arthropathy is caused by repeated joint bleeding episodes, primarily affecting knees, ankles and elbows. Conservative options should be considered prior to surgery, as well as postural evaluation, since any functional overload promotes the development of new bleeding. The aim of this study is to verify the use of foot orthoses in combination with postural rehabilitation, assessing the incidence of spontaneous haemarthroses and haematomas. In total, 15 patients were enrolled and randomly divided into two groups: 8 in group A, composed of patients who were prescribed foot orthoses and a 20-session rehabilitation program, and 7 in group B, composed of patients who were instructed to use foot orthoses only. All patients were evaluated at baseline (T0), at 3 months (T1—end of the rehabilitation program), and at 12 months (T2), using the following scales: Functional Independence Score in Haemophilia (FISH), Haemophilia Joint Health Score (HJHS) and Numerical Rating Scale (NRS). During the 12 months between the first and the last assessment, no patient in group A developed hemarthroses or hematomas, while one case of hemarthrosis was recorded in group B. The HJHS improved significantly (≤0.05) in group A at both T1 and T2, while in group B it improved significantly only in T2. As for FISH, it showed significant improvements in both groups at T1 and T2. NRS showed a significant reduction only at T2 in both groups (p-value T0–T1 0.3 in group A e 0.8 in group B). No patient reported any adverse effects from the use of orthotic insoles. The combination of postural rehabilitation, the use of foot orthoses and pharmacological prophylaxis could improve functioning and joint status in patients affected by haemophilic arthopathy, delaying or preventing new hemarthroses by improving the distribution of joint loads and the modification of musculoskeletal system’s characteristics. Full article
(This article belongs to the Special Issue Novel Therapeutics for Musculoskeletal Disorders)
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