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Cells, Volume 12, Issue 19

October-1 2023 - 91 articles

Cover Story: “MicroRNA-30d-5p as a Therapeutic Target for Cardiac Remodeling Post-Myocardial Infarction” describes the potential of miR-30d-5p as a therapeutic intervention for alleviating adverse cardiac remodeling after myocardial infarction (MI). The research reveals a significant downregulation of miR-30d-5p in ischemic myocardium. Administering a miR-30d-5p mimic in an experimental setting leads to a notable reduction in the left ventricle's infarct area size following MI. In vitro experiments employing HUVECs demonstrate accelerated cell migration in response to miR-30d-5p mimic treatment. The study highlights the potential anti-apoptotic effect of miR-30d-5p, implying a decrease in the apoptosis rate in human cardiomyocytes. The findings underscore miR-30d-5p’s cardioprotective potential and its role in mitigating the risk of ischemic cardiomyopathy development following MI. View this paper
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Articles (91)

  • Review
  • Open Access
24 Citations
7,414 Views
18 Pages

Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia

  • Kunihiro Sakuma,
  • Kento Hamada,
  • Akihiko Yamaguchi and
  • Wataru Aoi

9 October 2023

Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritiona...

  • Review
  • Open Access
16 Citations
3,760 Views
24 Pages

9 October 2023

Respiratory diseases represent a significant economic and health burden worldwide, affecting millions of individuals each year in both human and animal populations. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are involved...

  • Article
  • Open Access
3 Citations
1,984 Views
15 Pages

Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma

  • I-Cheng Lin,
  • Chih-Hui Chang,
  • Yoon Bin Chong,
  • Shih-Hsun Kuo,
  • Yu-Wen Cheng,
  • Ann-Shung Lieu,
  • Tzu-Ting Tseng,
  • Chien-Ju Lin,
  • Hung-Pei Tsai and
  • Aij-Lie Kwan

9 October 2023

Glioblastoma (GBM) stands as the most prevalent primary malignant brain tumor, typically resulting in a median survival period of approximately thirteen to fifteen months after undergoing surgery, chemotherapy, and radiotherapy. Nucleobindin-2 (NUCB2...

  • Article
  • Open Access
7 Citations
3,039 Views
14 Pages

Age-Dependent Surface Receptor Expression Patterns in Immature Versus Mature Platelets in Mouse Models of Regenerative Thrombocytopenia

  • Anita Pirabe,
  • Sabine Frühwirth,
  • Laura Brunnthaler,
  • Hubert Hackl,
  • Anna Schmuckenschlager,
  • Waltraud C. Schrottmaier and
  • Alice Assinger

8 October 2023

Aging is a multifaceted process that unfolds at both the individual and cellular levels, resulting in changes in platelet count and platelet reactivity. These alterations are influenced by shifts in platelet production, as well as by various environm...

  • Article
  • Open Access
7 Citations
3,173 Views
15 Pages

Mapping Cell-in-Cell Structures in Oral Squamous Cell Carcinoma

  • Leonardo de Oliveira Siquara da Rocha,
  • Bruno Solano de Freitas Souza,
  • Ricardo Della Coletta,
  • Daniel W. Lambert and
  • Clarissa A. Gurgel Rocha

8 October 2023

Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In vitro 3D models may contribute to the understanding of the underlying molecular mechanisms of these events. We employed a s...

  • Review
  • Open Access
24 Citations
6,173 Views
48 Pages

Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use

  • Francesca Conti,
  • Mattia Moratti,
  • Lucia Leonardi,
  • Arianna Catelli,
  • Elisa Bortolamedi,
  • Emanuele Filice,
  • Anna Fetta,
  • Marianna Fabi,
  • Elena Facchini and
  • Maria Elena Cantarini
  • + 5 authors

7 October 2023

Background: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-...

  • Article
  • Open Access
11 Citations
3,145 Views
17 Pages

7 October 2023

Cerium oxide nanoparticles (CeO2 NPs) are metal-oxide-based nanozymes with unique reactive oxygen species (ROS) scavenging abilities. Here, we studied new CeO2 NPs modified with calcein (CeO2-calcein) as an intracellular ROS inactivation/visualizatio...

  • Article
  • Open Access
1 Citations
2,417 Views
16 Pages

The Study of the Caudal Vertebrae of Thick-Toed Geckos after a Prolonged Space Flight by X-ray Phase-Contrast Micro-CT

  • Inna Bukreeva,
  • Victoria I. Gulimova,
  • Yuri S. Krivonosov,
  • Alexey V. Buzmakov,
  • Olga Junemann,
  • Alessia Cedola,
  • Michela Fratini,
  • Laura Maugeri,
  • Ginevra Begani Provinciali and
  • Francesca Palermo
  • + 4 authors

7 October 2023

The proximal caudal vertebrae and notochord in thick-toed geckos (TG) (Chondrodactylus turneri, Gray, 1864) were investigated after a 30-day space flight onboard the biosatellite Bion-M1. This region has not been explored in previous studies. Our res...

  • Article
  • Open Access
4 Citations
2,252 Views
19 Pages

Mitochondrial F-ATP Synthase Co-Migrating Proteins and Ca2+-Dependent Formation of Large Channels

  • Anna B. Nikiforova,
  • Yulia L. Baburina,
  • Marina P. Borisova,
  • Alexey K. Surin,
  • Ekaterina S. Kharechkina,
  • Olga V. Krestinina,
  • Maria Y. Suvorina,
  • Svetlana A. Kruglova and
  • Alexey G. Kruglov

7 October 2023

Monomers, dimers, and individual FOF1-ATP synthase subunits are, presumably, involved in the formation of the mitochondrial permeability transition pore (PTP), whose molecular structure, however, is still unknown. We hypothesized that, during the Ca2...

  • Review
  • Open Access
12 Citations
5,455 Views
17 Pages

Potential Therapeutic Use of Stem Cells for Prion Diseases

  • Mohammed Zayed,
  • Sung-Ho Kook and
  • Byung-Hoon Jeong

7 October 2023

Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC). PrPC is involved in a variety of physiological functions,...

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Cells - ISSN 2073-4409